Motif ID: Hoxb2_Dlx2

Z-value: 0.698

Transcription factors associated with Hoxb2_Dlx2:

Gene SymbolEntrez IDGene Name
Dlx2 ENSMUSG00000023391.7 Dlx2
Hoxb2 ENSMUSG00000075588.5 Hoxb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx2mm10_v2_chr2_-_71546745_715467580.724.8e-07Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb2_Dlx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_14621805 3.406 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr3_-_116253467 3.318 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr2_+_71528657 3.087 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr12_+_38780284 2.997 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr2_+_125136692 2.953 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr12_+_38780817 2.901 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr2_-_164171113 2.853 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr6_+_125552948 2.697 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr15_-_11037968 2.571 ENSMUST00000058007.5
Rxfp3
relaxin family peptide receptor 3
chr6_+_8948608 2.478 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr12_+_38783503 2.466 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr4_-_14621494 2.335 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr15_-_79285502 2.255 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr1_-_140183404 2.135 ENSMUST00000066859.6
ENSMUST00000111976.2
Cfh

complement component factor h

chr3_+_68572245 2.035 ENSMUST00000170788.2
Schip1
schwannomin interacting protein 1
chr2_-_77703252 2.005 ENSMUST00000171063.1
Zfp385b
zinc finger protein 385B
chr15_+_92597104 1.886 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr15_+_21111452 1.870 ENSMUST00000075132.6
Cdh12
cadherin 12
chr2_-_71546745 1.866 ENSMUST00000024159.6
Dlx2
distal-less homeobox 2
chr18_+_23415400 1.854 ENSMUST00000115832.2
ENSMUST00000047954.7
Dtna

dystrobrevin alpha

chr9_-_112187766 1.797 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr1_-_152625212 1.786 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr10_-_25200110 1.749 ENSMUST00000100012.2
Akap7
A kinase (PRKA) anchor protein 7
chr6_-_147264124 1.624 ENSMUST00000052296.6
Pthlh
parathyroid hormone-like peptide
chr4_-_14621669 1.621 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr1_-_140183283 1.528 ENSMUST00000111977.1
Cfh
complement component factor h
chr3_+_122419772 1.484 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr12_-_40037387 1.456 ENSMUST00000146905.1
Arl4a
ADP-ribosylation factor-like 4A
chr18_-_80986578 1.440 ENSMUST00000057950.7
Sall3
sal-like 3 (Drosophila)
chr6_+_30541582 1.433 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr12_+_109545390 1.395 ENSMUST00000146701.1
Meg3
maternally expressed 3
chr15_-_37458523 1.373 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr13_-_102906046 1.366 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr6_-_136171722 1.268 ENSMUST00000053880.6
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr2_+_73271925 1.245 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr9_-_77251829 1.242 ENSMUST00000184322.1
ENSMUST00000184316.1
Mlip

muscular LMNA-interacting protein

chr18_+_37518341 1.213 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chr5_+_104435112 1.196 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
Spp1





secreted phosphoprotein 1





chr5_+_139543889 1.189 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr13_-_114458720 1.169 ENSMUST00000022287.5
Fst
follistatin
chr9_+_94669876 1.137 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr13_+_94083490 1.136 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr6_-_23248264 1.133 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr15_-_78120011 1.124 ENSMUST00000019290.2
Cacng2
calcium channel, voltage-dependent, gamma subunit 2
chr14_-_48665098 1.101 ENSMUST00000118578.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr2_-_77519565 1.098 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr17_-_90088343 1.066 ENSMUST00000173917.1
Nrxn1
neurexin I
chr6_-_124779686 1.047 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr9_-_79977782 1.002 ENSMUST00000093811.4
Filip1
filamin A interacting protein 1
chr13_+_118714678 1.001 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chr19_-_59170978 0.990 ENSMUST00000172821.2
Vax1
ventral anterior homeobox containing gene 1
chr3_+_134236483 0.987 ENSMUST00000181904.1
ENSMUST00000053048.9
Cxxc4

CXXC finger 4

chr9_+_54980880 0.980 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chrM_+_7005 0.969 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr4_+_136143497 0.959 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr12_+_38783455 0.949 ENSMUST00000161980.1
ENSMUST00000160701.1
Etv1

ets variant gene 1

chrM_+_7759 0.941 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr2_+_109917639 0.926 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr9_-_55919605 0.900 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr4_+_13751297 0.899 ENSMUST00000105566.2
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_-_120068263 0.893 ENSMUST00000064165.3
ENSMUST00000177637.1
Cx3cr1

chemokine (C-X3-C) receptor 1

chr12_+_38781093 0.885 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr13_-_102905740 0.884 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr9_-_77251871 0.883 ENSMUST00000183955.1
Mlip
muscular LMNA-interacting protein
chr2_-_33086366 0.878 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr7_-_66427469 0.868 ENSMUST00000015278.7
Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr16_-_76373827 0.867 ENSMUST00000121927.1
Nrip1
nuclear receptor interacting protein 1
chr6_+_124304646 0.852 ENSMUST00000112541.2
ENSMUST00000032234.2
Cd163

CD163 antigen

chr7_+_126950687 0.845 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr2_+_155940728 0.843 ENSMUST00000109629.1
Gm15557
predicted gene 15557
chr10_+_85386813 0.841 ENSMUST00000105307.1
ENSMUST00000020231.3
Btbd11

BTB (POZ) domain containing 11

chr3_+_62419668 0.839 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr10_-_53647080 0.839 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr17_-_24073479 0.834 ENSMUST00000017090.5
Kctd5
potassium channel tetramerisation domain containing 5
chr4_+_5724304 0.826 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr7_+_126950518 0.826 ENSMUST00000106335.1
ENSMUST00000146017.1
Sez6l2

seizure related 6 homolog like 2

chr8_+_121116163 0.825 ENSMUST00000054691.6
Foxc2
forkhead box C2
chrX_+_114474312 0.820 ENSMUST00000113371.1
ENSMUST00000040504.5
Klhl4

kelch-like 4

chr1_-_132390301 0.812 ENSMUST00000132435.1
Tmcc2
transmembrane and coiled-coil domains 2
chr3_-_88461182 0.801 ENSMUST00000166237.1
Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr3_-_141982224 0.769 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr1_+_104768510 0.767 ENSMUST00000062528.8
Cdh20
cadherin 20
chr3_+_125404072 0.765 ENSMUST00000173932.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr4_+_13743424 0.758 ENSMUST00000006761.3
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_55782500 0.753 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr5_+_81021583 0.750 ENSMUST00000121707.1
Lphn3
latrophilin 3
chr10_+_99263224 0.744 ENSMUST00000020118.4
Dusp6
dual specificity phosphatase 6
chr3_-_55055038 0.726 ENSMUST00000029368.2
Ccna1
cyclin A1
chr9_-_123678782 0.711 ENSMUST00000170591.1
ENSMUST00000171647.1
Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr7_+_126950837 0.705 ENSMUST00000106332.1
Sez6l2
seizure related 6 homolog like 2
chr3_+_159839729 0.682 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr3_+_86070915 0.672 ENSMUST00000182666.1
Sh3d19
SH3 domain protein D19
chr5_-_134747241 0.668 ENSMUST00000015138.9
Eln
elastin
chr7_+_144838590 0.665 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chr13_+_75707484 0.664 ENSMUST00000001583.6
Ell2
elongation factor RNA polymerase II 2
chr3_+_125404292 0.659 ENSMUST00000144344.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_-_110143937 0.658 ENSMUST00000051253.3
Ntng1
netrin G1
chr6_-_56923927 0.648 ENSMUST00000031793.5
Nt5c3
5'-nucleotidase, cytosolic III
chr13_+_75967704 0.637 ENSMUST00000022081.1
Spata9
spermatogenesis associated 9
chr10_-_128744014 0.636 ENSMUST00000026414.7
Dgka
diacylglycerol kinase, alpha
chr16_+_45094036 0.634 ENSMUST00000061050.5
Ccdc80
coiled-coil domain containing 80
chr3_+_55461758 0.607 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr1_-_158356258 0.605 ENSMUST00000004133.8
Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr2_-_5676046 0.599 ENSMUST00000114987.3
Camk1d
calcium/calmodulin-dependent protein kinase ID
chr16_-_42340595 0.597 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr1_+_66468364 0.592 ENSMUST00000061620.9
Unc80
unc-80 homolog (C. elegans)
chr5_+_81021202 0.588 ENSMUST00000117253.1
ENSMUST00000120128.1
Lphn3

latrophilin 3

chrX_-_150814265 0.569 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
Maged2


melanoma antigen, family D, 2


chr2_+_152754156 0.566 ENSMUST00000010020.5
Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr18_+_23752333 0.556 ENSMUST00000170802.1
ENSMUST00000155708.1
ENSMUST00000118826.2
Mapre2


microtubule-associated protein, RP/EB family, member 2


chr2_-_120154600 0.551 ENSMUST00000028755.7
Ehd4
EH-domain containing 4
chr11_-_82890541 0.543 ENSMUST00000092844.6
ENSMUST00000021033.9
ENSMUST00000018985.8
Rad51d


RAD51 homolog D


chr5_+_27261916 0.539 ENSMUST00000101471.3
Dpp6
dipeptidylpeptidase 6
chr3_+_66219909 0.535 ENSMUST00000029421.5
Ptx3
pentraxin related gene
chr5_-_137684665 0.525 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
Agfg2


ArfGAP with FG repeats 2


chrX_-_139871637 0.522 ENSMUST00000033811.7
ENSMUST00000087401.5
Morc4

microrchidia 4

chr1_+_178798438 0.520 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr13_+_51408618 0.519 ENSMUST00000087978.3
S1pr3
sphingosine-1-phosphate receptor 3
chr10_+_73821857 0.516 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
Pcdh15



















protocadherin 15



















chr18_+_37504264 0.503 ENSMUST00000052179.6
Pcdhb20
protocadherin beta 20
chr17_+_34039437 0.501 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
Col11a2



collagen, type XI, alpha 2



chr3_+_122044428 0.488 ENSMUST00000013995.8
Abca4
ATP-binding cassette, sub-family A (ABC1), member 4
chr19_+_24673998 0.488 ENSMUST00000057243.4
Tmem252
transmembrane protein 252
chr15_-_8710409 0.487 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_+_4755327 0.481 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr6_-_50456085 0.476 ENSMUST00000146341.1
ENSMUST00000071728.4
Osbpl3

oxysterol binding protein-like 3

chr16_-_65562686 0.453 ENSMUST00000004965.6
Chmp2b
charged multivesicular body protein 2B
chrX_-_134111852 0.451 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr1_+_87755870 0.435 ENSMUST00000144047.1
ENSMUST00000027512.6
ENSMUST00000113186.1
ENSMUST00000113190.2
Atg16l1



autophagy related 16-like 1 (S. cerevisiae)



chr2_+_4559742 0.430 ENSMUST00000176828.1
Frmd4a
FERM domain containing 4A
chr6_+_17749170 0.428 ENSMUST00000053148.7
ENSMUST00000115417.3
St7

suppression of tumorigenicity 7

chr8_-_105568298 0.422 ENSMUST00000005849.5
Agrp
agouti related protein
chrX_+_56779437 0.421 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chr4_+_41966058 0.418 ENSMUST00000108026.2
Gm20938
predicted gene, 20938
chr15_-_8710734 0.417 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr18_-_75697639 0.415 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor
chr2_-_166155624 0.406 ENSMUST00000109249.2
Sulf2
sulfatase 2
chr8_+_23669653 0.399 ENSMUST00000042352.4
Zmat4
zinc finger, matrin type 4
chr4_-_35845204 0.396 ENSMUST00000164772.1
ENSMUST00000065173.2
Lingo2

leucine rich repeat and Ig domain containing 2

chr9_+_32116040 0.395 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr7_-_100964371 0.393 ENSMUST00000060174.4
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr3_+_138065052 0.392 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr13_-_78196373 0.387 ENSMUST00000125176.2
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chrX_+_99975570 0.380 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr10_+_39612934 0.379 ENSMUST00000019987.6
Traf3ip2
TRAF3 interacting protein 2
chr6_+_29853746 0.378 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
Ahcyl2



S-adenosylhomocysteine hydrolase-like 2



chr3_+_133338936 0.378 ENSMUST00000150386.1
ENSMUST00000125858.1
Ppa2

pyrophosphatase (inorganic) 2

chr1_+_89454769 0.372 ENSMUST00000027521.8
ENSMUST00000074945.5
Agap1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr5_-_123141067 0.371 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
AI480526


expressed sequence AI480526


chr11_-_96075581 0.368 ENSMUST00000107686.1
ENSMUST00000107684.1
Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr11_+_116671658 0.365 ENSMUST00000106378.1
ENSMUST00000144049.1
1810032O08Rik

RIKEN cDNA 1810032O08 gene

chr11_-_96075655 0.362 ENSMUST00000090541.5
Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr6_+_145934113 0.358 ENSMUST00000032383.7
Sspn
sarcospan
chr2_-_166155272 0.358 ENSMUST00000088086.3
Sulf2
sulfatase 2
chr6_+_29859374 0.356 ENSMUST00000115238.3
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr14_-_79771305 0.356 ENSMUST00000039568.5
Pcdh8
protocadherin 8
chr7_-_116198487 0.349 ENSMUST00000181981.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr13_+_42680565 0.349 ENSMUST00000128646.1
Phactr1
phosphatase and actin regulator 1
chr13_-_100616911 0.346 ENSMUST00000168772.1
ENSMUST00000163163.1
ENSMUST00000022137.7
Marveld2


MARVEL (membrane-associating) domain containing 2


chr16_+_45093611 0.342 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80
chr19_+_26749726 0.342 ENSMUST00000175842.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_+_43401232 0.337 ENSMUST00000125399.1
Rusc2
RUN and SH3 domain containing 2
chr8_+_4238815 0.318 ENSMUST00000003027.7
ENSMUST00000110999.1
Map2k7

mitogen-activated protein kinase kinase 7

chr19_+_26750939 0.318 ENSMUST00000175953.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_+_4238733 0.318 ENSMUST00000110998.2
ENSMUST00000062686.4
Map2k7

mitogen-activated protein kinase kinase 7

chr8_-_54724317 0.318 ENSMUST00000129132.2
ENSMUST00000150488.1
ENSMUST00000127511.2
Wdr17


WD repeat domain 17


chr2_+_4017727 0.316 ENSMUST00000177457.1
Frmd4a
FERM domain containing 4A
chr3_-_86548268 0.316 ENSMUST00000077524.3
Mab21l2
mab-21-like 2 (C. elegans)
chr18_+_56432116 0.309 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr1_-_79440039 0.308 ENSMUST00000049972.4
Scg2
secretogranin II
chr3_-_50443603 0.307 ENSMUST00000029297.4
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr1_-_9299238 0.305 ENSMUST00000140295.1
Sntg1
syntrophin, gamma 1
chr4_+_108719649 0.303 ENSMUST00000178992.1
3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr14_-_48662740 0.301 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr18_-_43477764 0.295 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr5_+_15516489 0.295 ENSMUST00000178227.1
Gm21847
predicted gene, 21847
chr14_-_41004517 0.293 ENSMUST00000153830.1
Fam213a
family with sequence similarity 213, member A
chr1_-_89933290 0.292 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr11_-_69666062 0.284 ENSMUST00000108654.2
ENSMUST00000018918.5
Cd68

CD68 antigen

chr8_+_107031218 0.277 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)
chr2_+_36230426 0.271 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr13_-_53473074 0.266 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr11_+_101582236 0.253 ENSMUST00000039581.7
ENSMUST00000100403.2
ENSMUST00000107194.1
ENSMUST00000128614.1
Tmem106a



transmembrane protein 106A



chr7_-_100656953 0.250 ENSMUST00000107046.1
ENSMUST00000107045.1
ENSMUST00000139708.1
Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr6_+_29859662 0.249 ENSMUST00000128927.2
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr1_+_110099295 0.246 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr14_-_46390501 0.242 ENSMUST00000100676.2
Bmp4
bone morphogenetic protein 4
chr10_+_75037066 0.242 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chr2_+_22622183 0.241 ENSMUST00000028123.3
Gad2
glutamic acid decarboxylase 2
chr13_-_58354862 0.239 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr8_-_54724474 0.238 ENSMUST00000175915.1
Wdr17
WD repeat domain 17
chr11_+_52098681 0.237 ENSMUST00000020608.2
Ppp2ca
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
chr17_+_46161021 0.229 ENSMUST00000024748.7
ENSMUST00000172170.1
Gtpbp2

GTP binding protein 2

chr18_+_4993795 0.225 ENSMUST00000153016.1
Svil
supervillin
chr2_-_27475622 0.221 ENSMUST00000138693.1
ENSMUST00000113941.2
ENSMUST00000077737.6
Brd3


bromodomain containing 3


chrX_-_157415286 0.219 ENSMUST00000079945.4
ENSMUST00000138396.1
Phex

phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)

chr6_+_134981998 0.219 ENSMUST00000167323.1
Apold1
apolipoprotein L domain containing 1
chr6_-_99266494 0.217 ENSMUST00000113326.2
Foxp1
forkhead box P1
chr3_-_126998408 0.217 ENSMUST00000182764.1
ENSMUST00000044443.8
Ank2

ankyrin 2, brain

chr15_+_85510812 0.217 ENSMUST00000079690.2
Gm4825
predicted pseudogene 4825

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
1.1 7.4 GO:0019532 oxalate transport(GO:0019532)
0.9 10.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.8 3.3 GO:0061743 motor learning(GO:0061743)
0.6 3.7 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.4 2.6 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.4 0.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.4 1.4 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.3 1.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.3 0.9 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.3 1.2 GO:0035937 androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.3 0.9 GO:0060166 olfactory pit development(GO:0060166)
0.3 0.9 GO:0001543 ovarian follicle rupture(GO:0001543)
0.3 0.8 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.3 1.1 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.3 1.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 0.7 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.2 0.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 0.9 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.2 0.7 GO:0030916 otic vesicle formation(GO:0030916)
0.2 0.4 GO:0030321 transepithelial chloride transport(GO:0030321)
0.2 0.8 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 0.5 GO:0072092 ureteric bud invasion(GO:0072092)
0.2 0.3 GO:0072179 nephric duct formation(GO:0072179)
0.2 0.5 GO:0060023 soft palate development(GO:0060023)
0.2 1.4 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.2 2.9 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.2 0.5 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.1 1.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 0.4 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 2.3 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 1.1 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 1.0 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.1 1.1 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.7 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 1.0 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.4 GO:0061739 protein lipidation involved in autophagosome assembly(GO:0061739)
0.1 2.0 GO:0008210 luteinization(GO:0001553) estrogen metabolic process(GO:0008210)
0.1 0.5 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.1 2.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 0.6 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.1 0.6 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.3 GO:0009838 abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 1.3 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.1 0.5 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 2.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.2 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.7 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.1 0.4 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.3 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.1 0.6 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 0.5 GO:0050957 equilibrioception(GO:0050957)
0.1 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.3 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.1 1.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.6 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.1 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.9 GO:0006953 acute-phase response(GO:0006953)
0.1 1.4 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 0.1 GO:0061144 alveolar secondary septum development(GO:0061144)
0.1 1.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.6 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.5 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.0 0.8 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.5 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602) regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
0.0 0.2 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.0 1.0 GO:0030903 notochord development(GO:0030903)
0.0 0.8 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 1.6 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:0072106 regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107)
0.0 0.0 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0 0.3 GO:0021546 rhombomere development(GO:0021546)
0.0 1.8 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.7 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.2 GO:1904749 regulation of protein localization to nucleolus(GO:1904749)
0.0 3.4 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.2 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.2 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 2.5 GO:0001889 liver development(GO:0001889)
0.0 0.4 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.6 GO:0006907 pinocytosis(GO:0006907)
0.0 0.7 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.1 GO:0090306 spindle assembly involved in meiosis(GO:0090306)
0.0 0.9 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.1 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.2 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.6 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.1 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 1.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.2 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.3 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.8 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.0 GO:1904892 JAK-STAT cascade(GO:0007259) regulation of JAK-STAT cascade(GO:0046425) STAT cascade(GO:0097696) regulation of STAT cascade(GO:1904892)
0.0 0.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.3 GO:0061028 establishment of endothelial barrier(GO:0061028)
0.0 0.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) excitatory synapse assembly(GO:1904861)
0.0 0.1 GO:0033572 transferrin transport(GO:0033572)
0.0 0.1 GO:0097186 amelogenesis(GO:0097186)
0.0 0.1 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.1 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 2.3 GO:0071439 clathrin complex(GO:0071439)
0.2 0.7 GO:0071953 elastic fiber(GO:0071953)
0.1 2.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 1.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.5 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.5 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 1.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 2.4 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 0.7 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.3 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 3.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.7 GO:0071564 npBAF complex(GO:0071564)
0.0 0.7 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.0 0.3 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)
0.0 1.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)
0.0 1.8 GO:0030315 T-tubule(GO:0030315)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0000421 autophagosome membrane(GO:0000421)
0.0 3.1 GO:0001650 fibrillar center(GO:0001650)
0.0 2.1 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.7 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 3.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.1 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.2 GO:0055037 recycling endosome(GO:0055037)
0.0 1.0 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0001851 complement component C3b binding(GO:0001851)
0.7 7.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.6 2.6 GO:0004966 galanin receptor activity(GO:0004966)
0.3 1.8 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.3 2.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.2 0.9 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 0.9 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 1.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 1.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 1.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.2 0.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 0.5 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 1.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.9 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.1 0.6 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 1.0 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 2.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.8 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.2 GO:0048185 activin binding(GO:0048185)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 1.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.4 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.7 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 1.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.6 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 1.7 GO:0016208 AMP binding(GO:0016208)
0.1 1.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.9 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.5 GO:0000150 recombinase activity(GO:0000150)
0.1 1.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.5 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.2 GO:0015254 glycerol channel activity(GO:0015254)
0.0 1.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.3 GO:0039706 co-receptor binding(GO:0039706) BMP receptor binding(GO:0070700)
0.0 0.2 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.9 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.0 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.3 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.7 GO:0001968 fibronectin binding(GO:0001968)
0.0 2.3 GO:0002039 p53 binding(GO:0002039)
0.0 9.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.3 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.0 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 1.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.2 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.0 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.0 0.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.8 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.4 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.5 GO:0032934 cholesterol binding(GO:0015485) sterol binding(GO:0032934)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 0.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.3 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 3.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.6 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.5 ST_ADRENERGIC Adrenergic Pathway
0.0 1.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.2 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.7 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.3 2.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 1.6 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 1.0 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 9.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.6 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.0 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 0.2 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 2.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.7 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.1 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.6 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.7 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.6 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.5 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.2 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds