Motif ID: Hoxb3

Z-value: 1.146


Transcription factors associated with Hoxb3:

Gene SymbolEntrez IDGene Name
Hoxb3 ENSMUSG00000048763.5 Hoxb3



Activity profile for motif Hoxb3.

activity profile for motif Hoxb3


Sorted Z-values histogram for motif Hoxb3

Sorted Z-values for motif Hoxb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_8710734 9.213 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 7.301 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_-_85722474 5.260 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr4_-_14621805 5.121 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chrX_+_170009892 5.121 ENSMUST00000180251.1
Gm21887
predicted gene, 21887
chr13_+_94083490 4.914 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr12_+_74288735 4.891 ENSMUST00000095617.1
1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr9_-_54661870 4.372 ENSMUST00000034822.5
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr8_+_66386292 4.179 ENSMUST00000039540.5
ENSMUST00000110253.2
March1

membrane-associated ring finger (C3HC4) 1

chr2_+_116067213 4.020 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr14_-_64455903 4.005 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr12_+_84069325 3.895 ENSMUST00000046422.4
ENSMUST00000072505.4
Acot5

acyl-CoA thioesterase 5

chrY_+_90785442 3.868 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
Erdr1


erythroid differentiation regulator 1


chr9_-_120068263 3.851 ENSMUST00000064165.3
ENSMUST00000177637.1
Cx3cr1

chemokine (C-X3-C) receptor 1

chr12_-_25096080 3.407 ENSMUST00000020974.6
Id2
inhibitor of DNA binding 2
chr5_+_134932351 3.359 ENSMUST00000047196.7
ENSMUST00000111221.2
ENSMUST00000111219.1
ENSMUST00000068617.5
ENSMUST00000111218.1
ENSMUST00000136246.1
Wbscr27





Williams Beuren syndrome chromosome region 27 (human)





chr11_+_32283511 3.304 ENSMUST00000093209.3
Hba-a1
hemoglobin alpha, adult chain 1
chr3_-_121263314 3.246 ENSMUST00000029777.7
Tmem56
transmembrane protein 56
chr18_+_12741324 3.178 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
Cabyr


calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)


chr14_+_99298652 3.038 ENSMUST00000005279.6
Klf5
Kruppel-like factor 5
chr2_+_109917639 2.866 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chrY_+_90784738 2.786 ENSMUST00000179483.1
Erdr1
erythroid differentiation regulator 1
chr7_-_140154712 2.490 ENSMUST00000059241.7
Sprn
shadow of prion protein
chr4_-_14621494 2.389 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr18_+_37355271 2.235 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chr2_-_116067391 2.162 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr9_-_54661666 2.084 ENSMUST00000128624.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr7_+_57387304 2.057 ENSMUST00000085241.5
Gm9962
predicted gene 9962
chr12_-_83487708 1.991 ENSMUST00000177959.1
ENSMUST00000178756.1
Dpf3

D4, zinc and double PHD fingers, family 3

chr13_-_92030897 1.958 ENSMUST00000149630.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr10_-_125328957 1.829 ENSMUST00000063318.2
Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr10_+_40349265 1.820 ENSMUST00000044672.4
ENSMUST00000095743.2
Cdk19

cyclin-dependent kinase 19

chr8_+_54954728 1.772 ENSMUST00000033915.7
Gpm6a
glycoprotein m6a
chr4_-_14621669 1.722 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chrX_+_170010744 1.720 ENSMUST00000178789.1
Gm21887
predicted gene, 21887
chr2_+_91257323 1.654 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr8_+_23411490 1.615 ENSMUST00000033952.7
Sfrp1
secreted frizzled-related protein 1
chr11_+_101665541 1.584 ENSMUST00000039388.2
Arl4d
ADP-ribosylation factor-like 4D
chr7_+_67222544 1.501 ENSMUST00000058771.5
ENSMUST00000179106.1
Lysmd4

LysM, putative peptidoglycan-binding, domain containing 4

chr10_-_83648631 1.475 ENSMUST00000146876.2
ENSMUST00000176294.1
Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chrX_-_9256899 1.470 ENSMUST00000115553.2
Gm14862
predicted gene 14862
chr3_+_65666223 1.468 ENSMUST00000099075.2
ENSMUST00000107848.1
ENSMUST00000161794.1
Lekr1


leucine, glutamate and lysine rich 1


chr4_-_42034726 1.462 ENSMUST00000084677.2
Gm21093
predicted gene, 21093
chr19_-_32196393 1.429 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr17_-_47834682 1.288 ENSMUST00000066368.6
Mdfi
MyoD family inhibitor
chr19_-_11604828 1.287 ENSMUST00000025582.4
Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr5_-_106926245 1.285 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr17_-_45659312 1.256 ENSMUST00000120717.1
Capn11
calpain 11
chr8_+_40354303 1.255 ENSMUST00000136835.1
Micu3
mitochondrial calcium uptake family, member 3
chr5_+_63812447 1.207 ENSMUST00000081747.3
0610040J01Rik
RIKEN cDNA 0610040J01 gene
chr2_+_65620829 1.148 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr19_+_3323301 1.133 ENSMUST00000025835.4
Cpt1a
carnitine palmitoyltransferase 1a, liver
chr13_-_92483996 1.064 ENSMUST00000040106.7
Fam151b
family with sequence similarity 151, member B
chr12_+_16653470 1.045 ENSMUST00000111064.1
Ntsr2
neurotensin receptor 2
chr1_+_115684727 1.019 ENSMUST00000043725.7
Cntnap5a
contactin associated protein-like 5A
chr10_-_128525859 1.019 ENSMUST00000026427.6
Esyt1
extended synaptotagmin-like protein 1
chr9_+_119341487 0.992 ENSMUST00000175743.1
ENSMUST00000176397.1
Acaa1a

acetyl-Coenzyme A acyltransferase 1A

chr7_-_13053684 0.985 ENSMUST00000182490.1
Mzf1
myeloid zinc finger 1
chr11_+_116843278 0.969 ENSMUST00000106370.3
Mettl23
methyltransferase like 23
chr5_-_77115145 0.912 ENSMUST00000081964.5
Hopx
HOP homeobox
chr16_-_52296924 0.904 ENSMUST00000167115.1
Alcam
activated leukocyte cell adhesion molecule
chr9_-_75597643 0.855 ENSMUST00000164100.1
Tmod2
tropomodulin 2
chr9_-_96719404 0.852 ENSMUST00000140121.1
Zbtb38
zinc finger and BTB domain containing 38
chr10_+_90071095 0.845 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_45112890 0.836 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr9_+_53771499 0.826 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr5_+_103425181 0.807 ENSMUST00000048957.9
Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr7_-_44929410 0.793 ENSMUST00000107857.3
ENSMUST00000085399.6
ENSMUST00000167930.1
ENSMUST00000166972.1
Ap2a1



adaptor-related protein complex 2, alpha 1 subunit



chr10_+_116018213 0.783 ENSMUST00000063470.4
Ptprr
protein tyrosine phosphatase, receptor type, R
chr9_-_55919605 0.779 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chrM_+_10167 0.774 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr11_-_96075655 0.739 ENSMUST00000090541.5
Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr12_-_98577940 0.729 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr9_+_94669876 0.727 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr6_+_113333304 0.720 ENSMUST00000147945.1
Ogg1
8-oxoguanine DNA-glycosylase 1
chr13_-_56895737 0.691 ENSMUST00000022023.6
ENSMUST00000109871.1
Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr11_-_121388186 0.685 ENSMUST00000106107.2
Rab40b
Rab40b, member RAS oncogene family
chr11_+_103116228 0.682 ENSMUST00000053063.5
Hexim1
hexamethylene bis-acetamide inducible 1
chr5_-_118244861 0.656 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chr2_-_161109017 0.655 ENSMUST00000039782.7
ENSMUST00000134178.1
Chd6

chromodomain helicase DNA binding protein 6

chr2_+_3424123 0.642 ENSMUST00000061852.5
ENSMUST00000100463.3
ENSMUST00000102988.3
ENSMUST00000115066.1
Dclre1c



DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)



chr12_+_21417872 0.640 ENSMUST00000180671.1
Gm4419
predicted gene 4419
chrX_+_100729917 0.636 ENSMUST00000019503.7
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr7_-_67222412 0.617 ENSMUST00000181631.1
1700112J16Rik
RIKEN cDNA 1700112J16 gene
chr9_+_119341294 0.617 ENSMUST00000039784.5
Acaa1a
acetyl-Coenzyme A acyltransferase 1A
chr8_-_104534630 0.597 ENSMUST00000162466.1
ENSMUST00000034349.9
Nae1

NEDD8 activating enzyme E1 subunit 1

chr5_+_136987019 0.589 ENSMUST00000004968.4
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr9_-_15301555 0.570 ENSMUST00000034414.8
4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr2_+_36230426 0.549 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr5_+_145204523 0.537 ENSMUST00000085671.3
ENSMUST00000031601.7
Zkscan5

zinc finger with KRAB and SCAN domains 5

chr18_+_24603952 0.521 ENSMUST00000025120.6
Elp2
elongator acetyltransferase complex subunit 2
chr7_+_3645267 0.512 ENSMUST00000038913.9
Cnot3
CCR4-NOT transcription complex, subunit 3
chr9_-_96719549 0.494 ENSMUST00000128269.1
Zbtb38
zinc finger and BTB domain containing 38
chr11_-_96075581 0.477 ENSMUST00000107686.1
ENSMUST00000107684.1
Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr5_-_74531619 0.473 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Scfd2



Sec1 family domain containing 2



chr1_+_165461037 0.473 ENSMUST00000027853.5
Mpc2
mitochondrial pyruvate carrier 2
chr11_-_45955183 0.472 ENSMUST00000109254.1
Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr19_+_60811574 0.451 ENSMUST00000128357.1
ENSMUST00000119633.1
ENSMUST00000025957.8
Fam45a


family with sequence similarity 45, member A


chr18_+_49832622 0.447 ENSMUST00000180611.1
Dmxl1
Dmx-like 1
chr14_+_26259109 0.402 ENSMUST00000174494.1
Duxbl3
double homeobox B-like 3
chr7_-_45092130 0.391 ENSMUST00000148175.1
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45092198 0.378 ENSMUST00000140449.1
ENSMUST00000117546.1
ENSMUST00000019683.3
Rcn3


reticulocalbin 3, EF-hand calcium binding domain


chr7_-_114636299 0.375 ENSMUST00000032906.4
ENSMUST00000032907.7
Calca

calcitonin/calcitonin-related polypeptide, alpha

chr8_+_113635550 0.363 ENSMUST00000179926.1
Mon1b
MON1 homolog b (yeast)
chr13_-_67332525 0.354 ENSMUST00000168892.1
ENSMUST00000109735.2
Zfp595

zinc finger protein 595

chr5_-_138170992 0.345 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr14_+_101653967 0.329 ENSMUST00000002289.6
Uchl3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr4_+_102570065 0.312 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr3_-_62506970 0.307 ENSMUST00000029336.4
Dhx36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
chr10_+_116143881 0.293 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr12_-_98901478 0.286 ENSMUST00000065716.6
Eml5
echinoderm microtubule associated protein like 5
chr12_-_24493656 0.279 ENSMUST00000073088.2
Gm16372
predicted pseudogene 16372
chrM_+_7759 0.267 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr14_+_26119173 0.239 ENSMUST00000174564.1
Duxbl2
doubl homeobox B-like 2
chr14_+_26258786 0.239 ENSMUST00000172517.1
Duxbl3
double homeobox B-like 3
chr9_-_85749308 0.236 ENSMUST00000039213.8
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr17_-_24886304 0.229 ENSMUST00000044252.5
Nubp2
nucleotide binding protein 2
chr14_+_25980039 0.225 ENSMUST00000173155.1
Duxbl1
double homeobox B-like 1
chr1_-_33814516 0.224 ENSMUST00000044455.5
ENSMUST00000115167.1
Zfp451

zinc finger protein 451

chr12_-_21417526 0.222 ENSMUST00000049531.9
ENSMUST00000155480.1
Ywhaq

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

chr19_-_32061438 0.219 ENSMUST00000096119.4
Asah2
N-acylsphingosine amidohydrolase 2
chr11_+_69580359 0.211 ENSMUST00000005371.5
ENSMUST00000108658.3
ENSMUST00000171247.1
Trp53


transformation related protein 53


chr7_-_45091713 0.205 ENSMUST00000141576.1
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr5_-_137786681 0.194 ENSMUST00000132726.1
Mepce
methylphosphate capping enzyme
chr2_-_20943413 0.180 ENSMUST00000140230.1
Arhgap21
Rho GTPase activating protein 21
chr10_-_117148474 0.153 ENSMUST00000020381.3
Frs2
fibroblast growth factor receptor substrate 2
chr8_+_113635787 0.144 ENSMUST00000035777.8
Mon1b
MON1 homolog b (yeast)
chr14_-_75754475 0.125 ENSMUST00000049168.7
Cog3
component of oligomeric golgi complex 3
chr14_+_26119811 0.109 ENSMUST00000173617.1
Duxbl2
doubl homeobox B-like 2
chr4_-_41045381 0.102 ENSMUST00000054945.7
Aqp7
aquaporin 7
chr18_+_9958147 0.088 ENSMUST00000025137.7
Thoc1
THO complex 1
chr5_-_137531204 0.083 ENSMUST00000150063.2
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr13_+_44121167 0.051 ENSMUST00000163056.1
ENSMUST00000159595.1
Gm5083

predicted gene 5083

chr5_+_118245226 0.036 ENSMUST00000049138.7
2410131K14Rik
RIKEN cDNA 2410131K14 gene
chr14_-_46822232 0.033 ENSMUST00000111817.1
ENSMUST00000079314.5
Gmfb

glia maturation factor, beta

chr6_-_122340499 0.020 ENSMUST00000160843.1
Phc1
polyhomeotic-like 1 (Drosophila)
chr14_-_76010863 0.018 ENSMUST00000088922.4
Gtf2f2
general transcription factor IIF, polypeptide 2
chrM_+_8600 0.005 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr18_+_38296635 0.002 ENSMUST00000072376.5
ENSMUST00000170811.1
Rnf14

ring finger protein 14


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 16.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.3 9.2 GO:0019532 oxalate transport(GO:0019532)
1.0 5.0 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
1.0 3.9 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
1.0 2.9 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.8 3.9 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.6 2.3 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.4 3.0 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.4 3.3 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.3 1.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 0.8 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.2 8.1 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.2 4.2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.2 3.6 GO:0048240 sperm capacitation(GO:0048240)
0.2 0.5 GO:0019085 early viral transcription(GO:0019085)
0.2 0.7 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.2 1.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.6 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.9 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.8 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.5 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.1 0.7 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.1 1.3 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 1.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 0.6 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 0.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.7 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 1.3 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 0.2 GO:0090403 regulation of purine nucleotide catabolic process(GO:0033121) negative regulation of purine nucleotide catabolic process(GO:0033122) oxidative stress-induced premature senescence(GO:0090403)
0.1 0.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 1.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 4.3 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.1 2.0 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 0.3 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.1 0.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.2 GO:2000616 negative regulation of histone H3-K9 acetylation(GO:2000616)
0.1 1.2 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.4 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 1.4 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.8 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.2 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.7 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.7 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.1 GO:0048296 negative regulation of isotype switching(GO:0045829) isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296)
0.0 0.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 2.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.1 GO:0015793 glycerol transport(GO:0015793)
0.0 0.1 GO:0040031 snRNA modification(GO:0040031)
0.0 0.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 4.0 GO:0007568 aging(GO:0007568)
0.0 1.5 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 1.0 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 0.3 GO:0042755 eating behavior(GO:0042755)
0.0 0.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.2 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 3.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 3.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 3.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 24.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.0 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 12.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.9 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.6 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.8 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.7 GO:0071565 nBAF complex(GO:0071565)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.7 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.5 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.0 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 16.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.3 4.0 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.8 9.2 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.8 3.3 GO:0031720 haptoglobin binding(GO:0031720)
0.8 3.9 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.6 6.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.6 2.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.4 1.6 GO:0008410 CoA-transferase activity(GO:0008410)
0.3 1.4 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 3.9 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.2 0.7 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
0.2 2.9 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 1.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.2 0.5 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 0.6 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 1.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.9 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.7 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.7 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.6 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 1.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.4 GO:0042287 MHC protein binding(GO:0042287)
0.1 1.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.0 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 0.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.8 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.3 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.6 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 1.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.8 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 1.8 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 3.9 GO:0044325 ion channel binding(GO:0044325)
0.0 1.3 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 0.2 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.5 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.7 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 5.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.5 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 1.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 16.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 10.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 1.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 1.1 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.2 3.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.7 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 0.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 0.7 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 4.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.8 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.5 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.1 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins