Motif ID: Hoxb3

Z-value: 1.146


Transcription factors associated with Hoxb3:

Gene SymbolEntrez IDGene Name
Hoxb3 ENSMUSG00000048763.5 Hoxb3



Activity profile for motif Hoxb3.

activity profile for motif Hoxb3


Sorted Z-values histogram for motif Hoxb3

Sorted Z-values for motif Hoxb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb3

PNG image of the network

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Top targets:


Showing 1 to 20 of 139 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_8710734 9.213 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 7.301 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_-_85722474 5.260 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr4_-_14621805 5.121 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chrX_+_170009892 5.121 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr13_+_94083490 4.914 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr12_+_74288735 4.891 ENSMUST00000095617.1
 1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr9_-_54661870 4.372 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr8_+_66386292 4.179 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr2_+_116067213 4.020 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr14_-_64455903 4.005 ENSMUST00000067927.7
 Msra
methionine sulfoxide reductase A
chr12_+_84069325 3.895 ENSMUST00000046422.4
ENSMUST00000072505.4
 Acot5

acyl-CoA thioesterase 5

chrY_+_90785442 3.868 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
 Erdr1


erythroid differentiation regulator 1


chr9_-_120068263 3.851 ENSMUST00000064165.3
ENSMUST00000177637.1
 Cx3cr1

chemokine (C-X3-C) receptor 1

chr12_-_25096080 3.407 ENSMUST00000020974.6
 Id2
inhibitor of DNA binding 2
chr5_+_134932351 3.359 ENSMUST00000047196.7
ENSMUST00000111221.2
ENSMUST00000111219.1
ENSMUST00000068617.5
ENSMUST00000111218.1
ENSMUST00000136246.1
 Wbscr27





Williams Beuren syndrome chromosome region 27 (human)





chr11_+_32283511 3.304 ENSMUST00000093209.3
 Hba-a1
hemoglobin alpha, adult chain 1
chr3_-_121263314 3.246 ENSMUST00000029777.7
 Tmem56
transmembrane protein 56
chr18_+_12741324 3.178 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
 Cabyr


calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)


chr14_+_99298652 3.038 ENSMUST00000005279.6
 Klf5
Kruppel-like factor 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 16.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.3 9.2 GO:0019532 oxalate transport(GO:0019532)
0.2 8.1 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
1.0 5.0 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 4.3 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.2 4.2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 4.0 GO:0007568 aging(GO:0007568)
1.0 3.9 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.8 3.9 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.2 3.6 GO:0048240 sperm capacitation(GO:0048240)
0.4 3.3 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.4 3.0 GO:0032534 regulation of microvillus assembly(GO:0032534)
1.0 2.9 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.6 2.3 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.0 2.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.0 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 1.8 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 1.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.5 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.2 1.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 12.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 3.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 3.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.8 3.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 3.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.8 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.0 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.0 GO:0043198 dendritic shaft(GO:0043198)
0.1 0.9 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 16.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.8 9.2 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.6 6.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.3 4.0 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.8 3.9 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.2 3.9 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 3.9 GO:0044325 ion channel binding(GO:0044325)
0.8 3.3 GO:0031720 haptoglobin binding(GO:0031720)
0.2 2.9 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.6 2.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.8 GO:0005262 calcium channel activity(GO:0005262)
0.1 1.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.4 1.6 GO:0008410 CoA-transferase activity(GO:0008410)
0.1 1.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 1.4 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 1.4 GO:0042287 MHC protein binding(GO:0042287)
0.1 1.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.3 GO:0008327 methyl-CpG binding(GO:0008327)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 1.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 10.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 4.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 3.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 1.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 1.1 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 1.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 0.7 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 0.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 0.7 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.5 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.1 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins