Motif ID: Hoxb4

Z-value: 0.319


Transcription factors associated with Hoxb4:

Gene SymbolEntrez IDGene Name
Hoxb4 ENSMUSG00000038692.7 Hoxb4



Activity profile for motif Hoxb4.

activity profile for motif Hoxb4


Sorted Z-values histogram for motif Hoxb4

Sorted Z-values for motif Hoxb4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_84775420 2.626 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_84775388 2.613 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr10_-_92162753 1.469 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr8_-_105471481 1.397 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr17_+_43952999 0.969 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr17_+_86963279 0.801 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr1_-_45503282 0.787 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr16_-_37384940 0.394 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr18_-_15063560 0.379 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr16_-_37384915 0.339 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr3_-_54714353 0.325 ENSMUST00000178832.1
 Gm21958
predicted gene, 21958
chr3_-_39359128 0.315 ENSMUST00000056409.2
 Gm9845
predicted pseudogene 9845
chr10_-_89621253 0.281 ENSMUST00000020102.7
 Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chrX_-_49797700 0.270 ENSMUST00000033442.7
ENSMUST00000114891.1
 Igsf1

immunoglobulin superfamily, member 1

chr3_-_51277470 0.263 ENSMUST00000108053.2
ENSMUST00000108051.1
 Elf2

E74-like factor 2

chr18_-_56562261 0.222 ENSMUST00000066208.6
ENSMUST00000172734.1
 Aldh7a1

aldehyde dehydrogenase family 7, member A1

chr17_+_25951472 0.186 ENSMUST00000181174.1
 D630044L22Rik
RIKEN cDNA gene D630044L22 gene
chr5_+_143363890 0.165 ENSMUST00000010969.8
 Grid2ip
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
chr18_-_56562215 0.160 ENSMUST00000170309.1
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr15_-_50889691 0.153 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr13_+_94083490 0.126 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chrX_-_8193387 0.125 ENSMUST00000143223.1
ENSMUST00000033509.8
 Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr8_+_25808474 0.113 ENSMUST00000033979.4
 Star
steroidogenic acute regulatory protein
chr1_+_10993452 0.106 ENSMUST00000027056.5
 Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr18_-_56562187 0.095 ENSMUST00000171844.2
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chrX_+_166344692 0.087 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr1_+_146497614 0.078 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr10_-_88605017 0.067 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr17_+_57279094 0.045 ENSMUST00000169220.2
ENSMUST00000005889.9
ENSMUST00000112870.4
 Vav1


vav 1 oncogene


chr9_-_60649793 0.006 ENSMUST00000053171.7
 Lrrc49
leucine rich repeat containing 49

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.3 0.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 1.0 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.1 GO:0070859 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.8 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 1.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.7 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.4 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.3 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 5.2 GO:0072562 blood microparticle(GO:0072562)
0.0 0.1 GO:0005859 muscle myosin complex(GO:0005859)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.2 GO:0001848 complement binding(GO:0001848)
0.2 1.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.5 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.1 0.8 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.3 GO:0034711 inhibin binding(GO:0034711)
0.0 0.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.1 GO:0097493 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 5.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions