Motif ID: Hoxb5

Z-value: 0.625


Transcription factors associated with Hoxb5:

Gene SymbolEntrez IDGene Name
Hoxb5 ENSMUSG00000038700.3 Hoxb5



Activity profile for motif Hoxb5.

activity profile for motif Hoxb5


Sorted Z-values histogram for motif Hoxb5

Sorted Z-values for motif Hoxb5



Network of associatons between targets according to the STRING database.


Top targets:


Showing 1 to 20 of 93 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56971762 4.146 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr5_+_125532377 3.977 ENSMUST00000031446.6
 Tmem132b
transmembrane protein 132B
chr6_-_18514802 2.554 ENSMUST00000090601.5
 Cttnbp2
cortactin binding protein 2
chr17_+_35076902 2.121 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr17_-_57087729 1.917 ENSMUST00000071135.5
 Tubb4a
tubulin, beta 4A class IVA
chr2_+_158667119 1.844 ENSMUST00000045503.4
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr17_+_35077080 1.733 ENSMUST00000172959.1
 Ly6g6e
lymphocyte antigen 6 complex, locus G6E
chr3_-_103737995 1.716 ENSMUST00000029440.8
 Olfml3
olfactomedin-like 3
chr12_-_78980758 1.593 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr11_+_74619594 1.557 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene
chr12_-_78983476 1.543 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr2_+_85136355 1.521 ENSMUST00000057019.7
 Aplnr
apelin receptor
chr10_-_63927434 1.360 ENSMUST00000079279.3
 Gm10118
predicted gene 10118
chr9_-_35116804 1.346 ENSMUST00000034537.6
 St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chrX_-_165327376 1.281 ENSMUST00000058787.8
 Glra2
glycine receptor, alpha 2 subunit
chr3_-_85722474 1.263 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr11_-_96075655 1.219 ENSMUST00000090541.5
 Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr11_-_96075581 1.179 ENSMUST00000107686.1
ENSMUST00000107684.1
 Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr17_-_47691403 1.130 ENSMUST00000113299.1
ENSMUST00000152214.1
 Gm21981
Prickle4
predicted gene 21981
prickle homolog 4 (Drosophila)
chr14_+_32159865 1.105 ENSMUST00000163336.1
ENSMUST00000169722.1
ENSMUST00000168385.1
 Ncoa4


nuclear receptor coactivator 4



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 3.9 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.1 3.0 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 2.4 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.4 1.8 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.5 1.5 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)
0.1 1.4 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.2 1.3 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 1.3 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 1.1 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 1.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.3 0.9 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.2 0.9 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
0.1 0.9 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.3 0.8 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.1 0.8 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.2 0.7 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.7 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 0.5 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.9 GO:0008021 synaptic vesicle(GO:0008021)
0.2 2.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 1.9 GO:0033269 internode region of axon(GO:0033269)
0.0 1.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.3 GO:0005776 autophagosome(GO:0005776)
0.1 1.1 GO:0044754 autolysosome(GO:0044754)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.0 GO:0030496 midbody(GO:0030496)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 0.8 GO:0044316 cone cell pedicle(GO:0044316)
0.1 0.8 GO:0016342 catenin complex(GO:0016342)
0.1 0.5 GO:0033391 chromatoid body(GO:0033391)
0.0 0.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 3.9 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.3 2.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 2.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.4 1.3 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.3 1.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 1.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 1.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 0.9 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.3 0.8 GO:0019966 C-X-C chemokine binding(GO:0019958) interleukin-1 binding(GO:0019966) tumor necrosis factor binding(GO:0043120)
0.2 0.8 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.2 0.8 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.3 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.9 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.6 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.1 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 1.0 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.9 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.9 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 0.8 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.8 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors