Motif ID: Hoxb7

Z-value: 2.649


Transcription factors associated with Hoxb7:

Gene SymbolEntrez IDGene Name
Hoxb7 ENSMUSG00000038721.8 Hoxb7



Activity profile for motif Hoxb7.

activity profile for motif Hoxb7


Sorted Z-values histogram for motif Hoxb7

Sorted Z-values for motif Hoxb7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_31713873 17.358 ENSMUST00000057783.4
ENSMUST00000174480.2
ENSMUST00000176710.1
 Gpr22


G protein-coupled receptor 22


chrX_-_43167817 15.979 ENSMUST00000115058.1
ENSMUST00000115059.1
 Tenm1

teneurin transmembrane protein 1

chr13_+_83504032 15.694 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr4_+_13751297 14.928 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_67892189 13.690 ENSMUST00000063263.3
 Iqcj
IQ motif containing J
chr2_+_65930117 12.735 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr10_-_64090241 11.735 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090265 11.577 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr4_+_102589687 11.567 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr6_-_144209558 10.708 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr6_-_144209471 10.533 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209448 10.335 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr11_-_30198232 9.995 ENSMUST00000102838.3
 Sptbn1
spectrin beta, non-erythrocytic 1
chr6_-_136171722 9.738 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr15_+_21111452 9.479 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr14_-_12345847 9.043 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chrX_-_43274786 8.826 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr2_-_7395879 8.638 ENSMUST00000182404.1
 Celf2
CUGBP, Elav-like family member 2
chr1_+_34005872 8.585 ENSMUST00000182296.1
 Dst
dystonin
chr2_-_7396192 8.565 ENSMUST00000137733.2
 Celf2
CUGBP, Elav-like family member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 441 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 50.0 GO:0006376 mRNA splice site selection(GO:0006376)
2.6 33.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.7 30.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
3.3 26.3 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
1.5 22.8 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
2.5 22.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.0 22.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.6 21.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
1.8 21.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.3 20.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
6.5 19.4 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.8 19.4 GO:0008090 retrograde axonal transport(GO:0008090)
1.9 17.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
2.4 16.9 GO:0019532 oxalate transport(GO:0019532)
2.7 16.2 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
1.1 15.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 14.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
4.8 14.3 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.6 14.1 GO:0002076 osteoblast development(GO:0002076)
1.7 13.7 GO:0005513 detection of calcium ion(GO:0005513)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 191 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 128.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 64.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.9 36.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 33.4 GO:0060076 excitatory synapse(GO:0060076)
1.1 22.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.4 20.9 GO:0044295 axonal growth cone(GO:0044295)
1.0 20.2 GO:0031430 M band(GO:0031430)
0.0 19.8 GO:0005794 Golgi apparatus(GO:0005794)
1.1 19.3 GO:0031045 dense core granule(GO:0031045)
1.1 19.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
4.5 17.9 GO:0031673 H zone(GO:0031673)
0.9 17.3 GO:0071564 npBAF complex(GO:0071564)
1.9 17.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 16.6 GO:0030017 sarcomere(GO:0030017)
0.5 14.9 GO:0032809 neuronal cell body membrane(GO:0032809)
2.6 13.0 GO:0032437 cuticular plate(GO:0032437)
0.0 13.0 GO:0005783 endoplasmic reticulum(GO:0005783)
4.2 12.6 GO:0043512 inhibin A complex(GO:0043512)
0.6 12.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 12.2 GO:0043209 myelin sheath(GO:0043209)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 252 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 50.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.7 41.7 GO:0030507 spectrin binding(GO:0030507)
1.4 37.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 31.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.6 29.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 28.3 GO:0042393 histone binding(GO:0042393)
0.1 28.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
1.1 25.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 24.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 24.0 GO:0008017 microtubule binding(GO:0008017)
2.9 23.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 19.7 GO:0005057 receptor signaling protein activity(GO:0005057)
0.2 19.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
2.9 17.3 GO:0070699 type II activin receptor binding(GO:0070699)
1.5 16.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.9 16.9 GO:0035198 miRNA binding(GO:0035198)
4.2 16.7 GO:0030348 syntaxin-3 binding(GO:0030348)
1.9 15.6 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529)
0.1 14.8 GO:0005096 GTPase activator activity(GO:0005096)
0.4 12.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 22.8 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.4 21.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.3 21.6 PID_LKB1_PATHWAY LKB1 signaling events
0.2 16.2 PID_CMYB_PATHWAY C-MYB transcription factor network
0.3 12.8 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.3 12.8 PID_FGF_PATHWAY FGF signaling pathway
0.3 11.3 PID_ALK1_PATHWAY ALK1 signaling events
0.2 11.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 9.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.2 9.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.3 9.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.2 9.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 7.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 6.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.3 6.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 6.4 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 5.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 5.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 5.2 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 4.9 PID_TNF_PATHWAY TNF receptor signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 40.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.9 36.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
1.0 26.8 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.3 22.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.6 20.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
1.6 15.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.8 15.0 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.4 15.0 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 14.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.6 13.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 12.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.5 12.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
3.1 12.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 9.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 8.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 7.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 7.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.5 6.7 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 6.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.4 6.0 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism