Motif ID: Hoxc10

Z-value: 0.462


Transcription factors associated with Hoxc10:

Gene SymbolEntrez IDGene Name
Hoxc10 ENSMUSG00000022484.7 Hoxc10



Activity profile for motif Hoxc10.

activity profile for motif Hoxc10


Sorted Z-values histogram for motif Hoxc10

Sorted Z-values for motif Hoxc10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc10

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_25469742 3.596 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr2_-_25470031 3.013 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr4_+_144893127 1.858 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr13_-_84064772 1.621 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr14_+_13454010 1.530 ENSMUST00000112656.2
 Synpr
synaptoporin
chr3_-_63851251 1.494 ENSMUST00000162269.2
ENSMUST00000159676.2
ENSMUST00000175947.1
 Plch1


phospholipase C, eta 1


chr5_+_117841839 1.236 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr5_-_62766153 1.229 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_+_104287855 1.127 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chrX_+_169685191 1.038 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr14_+_13453937 0.890 ENSMUST00000153954.1
 Synpr
synaptoporin
chr2_+_73271925 0.871 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr1_-_45503282 0.853 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr3_-_49757257 0.831 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr9_+_50575273 0.797 ENSMUST00000059081.6
ENSMUST00000180021.1
 Il18

interleukin 18

chr9_-_44799179 0.791 ENSMUST00000114705.1
ENSMUST00000002100.7
 Tmem25

transmembrane protein 25

chr5_-_111761697 0.787 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr6_-_136875794 0.744 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr17_-_35074485 0.727 ENSMUST00000007259.3
 Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr15_-_58214882 0.669 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr2_-_36104060 0.615 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr9_-_116175318 0.608 ENSMUST00000061101.4
ENSMUST00000035014.6
 Tgfbr2

transforming growth factor, beta receptor II

chr2_-_144527341 0.603 ENSMUST00000163701.1
ENSMUST00000081982.5
 Dzank1

double zinc ribbon and ankyrin repeat domains 1

chr3_+_89266552 0.597 ENSMUST00000040824.1
 Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr1_-_163289214 0.530 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr4_-_42661893 0.492 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2
chrM_+_3906 0.461 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr15_+_81936753 0.451 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr5_+_71699918 0.447 ENSMUST00000031122.7
 Gabrb1
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
chr15_+_81936911 0.446 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr11_-_79504078 0.434 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr18_-_15063560 0.422 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr4_+_11758147 0.413 ENSMUST00000029871.5
ENSMUST00000108303.1
 Cdh17

cadherin 17

chr15_+_85510812 0.411 ENSMUST00000079690.2
 Gm4825
predicted pseudogene 4825
chr7_-_139582790 0.406 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr7_-_73537621 0.404 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr8_-_47352348 0.394 ENSMUST00000110367.2
 Stox2
storkhead box 2
chr18_-_6490808 0.351 ENSMUST00000028100.6
ENSMUST00000050542.5
 Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr10_-_49783259 0.348 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
 Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr11_+_94211431 0.338 ENSMUST00000041589.5
 Tob1
transducer of ErbB-2.1
chr13_-_106847267 0.334 ENSMUST00000057427.4
 Lrrc70
leucine rich repeat containing 70
chr16_-_23988852 0.313 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr15_+_25773985 0.306 ENSMUST00000125667.1
 Myo10
myosin X
chr4_-_133967296 0.301 ENSMUST00000105893.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr2_-_26122769 0.298 ENSMUST00000140993.1
ENSMUST00000028300.5
 Nacc2

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

chr19_+_55894508 0.295 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr14_+_124005355 0.283 ENSMUST00000166105.1
 Gm17615
predicted gene, 17615
chr3_+_31902666 0.270 ENSMUST00000119970.1
ENSMUST00000178668.1
 Kcnmb2

potassium large conductance calcium-activated channel, subfamily M, beta member 2

chr1_+_191025350 0.261 ENSMUST00000181050.1
 A230020J21Rik
RIKEN cDNA A230020J21 gene
chr3_-_146770218 0.235 ENSMUST00000106137.1
 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr19_-_50678642 0.235 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr8_-_41016295 0.234 ENSMUST00000131965.1
 Mtus1
mitochondrial tumor suppressor 1
chr8_-_18741542 0.227 ENSMUST00000033846.6
 Angpt2
angiopoietin 2
chr17_-_78684262 0.214 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr9_+_37208291 0.195 ENSMUST00000034632.8
 Tmem218
transmembrane protein 218
chr6_-_124965485 0.190 ENSMUST00000112439.2
 Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr17_-_46680870 0.188 ENSMUST00000165007.1
ENSMUST00000071841.5
 Klhdc3

kelch domain containing 3

chr6_-_124965403 0.186 ENSMUST00000129446.1
ENSMUST00000032220.8
 Cops7a

COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)

chr7_+_103550368 0.183 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr2_+_130576170 0.159 ENSMUST00000028764.5
 Oxt
oxytocin
chr1_+_63176818 0.152 ENSMUST00000129339.1
 Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr17_+_46681038 0.151 ENSMUST00000002845.6
 Mea1
male enhanced antigen 1
chr3_+_32436151 0.149 ENSMUST00000029201.7
 Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr1_+_179960472 0.148 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr11_-_109472611 0.144 ENSMUST00000168740.1
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr2_+_80315461 0.136 ENSMUST00000028392.7
 Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr11_-_84067063 0.134 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr5_-_62765618 0.132 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_-_88410295 0.130 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr8_+_83666827 0.123 ENSMUST00000019608.5
 Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr6_-_124965248 0.115 ENSMUST00000129976.1
 Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr1_+_17601893 0.113 ENSMUST00000088476.2
 Pi15
peptidase inhibitor 15
chr19_-_56548122 0.108 ENSMUST00000026063.5
ENSMUST00000182276.1
 Dclre1a

DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae)

chr8_-_94012558 0.100 ENSMUST00000053766.6
 Amfr
autocrine motility factor receptor
chr11_-_97700327 0.098 ENSMUST00000018681.7
 Pcgf2
polycomb group ring finger 2
chr9_-_21287953 0.092 ENSMUST00000184326.1
ENSMUST00000038671.3
 Kri1

KRI1 homolog (S. cerevisiae)

chr14_-_54686060 0.090 ENSMUST00000125265.1
 Acin1
apoptotic chromatin condensation inducer 1
chr1_+_180111339 0.087 ENSMUST00000145181.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chr1_+_189728264 0.078 ENSMUST00000097442.2
 Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr13_+_24943144 0.071 ENSMUST00000021773.5
 Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr13_-_91388079 0.067 ENSMUST00000181054.1
 A830009L08Rik
RIKEN cDNA A830009L08 gene
chr1_+_179961110 0.061 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr1_-_63114516 0.043 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr11_-_120549695 0.034 ENSMUST00000034913.4
 Fam195b
family with sequence similarity 195, member B
chr17_-_90088343 0.032 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr1_-_97761538 0.023 ENSMUST00000171129.1
 Ppip5k2
diphosphoinositol pentakisphosphate kinase 2
chr1_-_63176653 0.013 ENSMUST00000027111.8
ENSMUST00000168099.2
 Ndufs1

NADH dehydrogenase (ubiquinone) Fe-S protein 1

chr7_-_30729505 0.003 ENSMUST00000006478.8
 Tmem147
transmembrane protein 147

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.6 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.4 1.2 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.3 0.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 0.8 GO:0032817 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819)
0.2 0.7 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 0.6 GO:0003274 endocardial cushion fusion(GO:0003274)
0.2 1.9 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 1.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.3 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.1 0.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 0.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.2 GO:0042713 sperm ejaculation(GO:0042713) negative regulation of gastric acid secretion(GO:0060455)
0.0 0.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.4 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.5 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.3 GO:1902373 negative regulation of mRNA catabolic process(GO:1902373)
0.0 0.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.5 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.7 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507)
0.0 0.3 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.2 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.4 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.4 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.3 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 1.1 GO:0035904 aorta development(GO:0035904)
0.0 0.1 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.3 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.7 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.2 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.6 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 1.2 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 2.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 5.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 0.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.5 GO:0008180 COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.6 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.4 1.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.3 1.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 0.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.6 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 0.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.7 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 1.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 0.4 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 1.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 0.1 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.0 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.0 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.4 PID_IL3_PATHWAY IL3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.1 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.6 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.2 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB