Motif ID: Hoxc10

Z-value: 0.462


Transcription factors associated with Hoxc10:

Gene SymbolEntrez IDGene Name
Hoxc10 ENSMUSG00000022484.7 Hoxc10



Activity profile for motif Hoxc10.

activity profile for motif Hoxc10


Sorted Z-values histogram for motif Hoxc10

Sorted Z-values for motif Hoxc10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc10

PNG image of the network

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Top targets:


Showing 1 to 20 of 88 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_25469742 3.596 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr2_-_25470031 3.013 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr4_+_144893127 1.858 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr13_-_84064772 1.621 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr14_+_13454010 1.530 ENSMUST00000112656.2
 Synpr
synaptoporin
chr3_-_63851251 1.494 ENSMUST00000162269.2
ENSMUST00000159676.2
ENSMUST00000175947.1
 Plch1


phospholipase C, eta 1


chr5_+_117841839 1.236 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr5_-_62766153 1.229 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_+_104287855 1.127 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chrX_+_169685191 1.038 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr14_+_13453937 0.890 ENSMUST00000153954.1
 Synpr
synaptoporin
chr2_+_73271925 0.871 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr1_-_45503282 0.853 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr3_-_49757257 0.831 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr9_+_50575273 0.797 ENSMUST00000059081.6
ENSMUST00000180021.1
 Il18

interleukin 18

chr9_-_44799179 0.791 ENSMUST00000114705.1
ENSMUST00000002100.7
 Tmem25

transmembrane protein 25

chr5_-_111761697 0.787 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr6_-_136875794 0.744 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr17_-_35074485 0.727 ENSMUST00000007259.3
 Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr15_-_58214882 0.669 ENSMUST00000022986.6
 Fbxo32
F-box protein 32

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 6.6 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.2 1.9 GO:0042572 retinol metabolic process(GO:0042572)
0.4 1.2 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.0 1.1 GO:0035904 aorta development(GO:0035904)
0.1 1.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.3 0.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 0.8 GO:0032817 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819)
0.0 0.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 0.7 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.7 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 0.7 GO:0030500 regulation of bone mineralization(GO:0030500)
0.2 0.6 GO:0003274 endocardial cushion fusion(GO:0003274)
0.1 0.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.5 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.5 GO:0000338 protein deneddylation(GO:0000338)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.4 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.4 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 2.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.2 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.3 0.9 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.6 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.5 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 6.6 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.3 1.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 1.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 1.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.7 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 0.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.6 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.4 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.4 PID_IL3_PATHWAY IL3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.1 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors