Motif ID: Hoxc6

Z-value: 0.276


Transcription factors associated with Hoxc6:

Gene SymbolEntrez IDGene Name
Hoxc6 ENSMUSG00000001661.4 Hoxc6



Activity profile for motif Hoxc6.

activity profile for motif Hoxc6


Sorted Z-values histogram for motif Hoxc6

Sorted Z-values for motif Hoxc6



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_17574268 1.244 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr4_+_144893127 0.884 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_+_5218546 0.732 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr3_+_151437887 0.508 ENSMUST00000046977.7
 Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr3_+_5218516 0.480 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr10_-_100589205 0.379 ENSMUST00000054471.8
 4930430F08Rik
RIKEN cDNA 4930430F08 gene
chr3_+_66985680 0.352 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chrM_-_14060 0.324 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr3_+_5218589 0.298 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr6_-_65144908 0.289 ENSMUST00000031982.4
 Hpgds
hematopoietic prostaglandin D synthase
chr19_+_11469353 0.289 ENSMUST00000165310.1
 Ms4a6c
membrane-spanning 4-domains, subfamily A, member 6C
chrM_+_14138 0.275 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr10_-_53647080 0.240 ENSMUST00000169866.1
 Fam184a
family with sequence similarity 184, member A
chr3_+_66985700 0.234 ENSMUST00000046542.6
ENSMUST00000162693.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr15_-_50889691 0.224 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr15_+_44619551 0.220 ENSMUST00000022964.7
 Ebag9
estrogen receptor-binding fragment-associated gene 9
chr10_-_58718210 0.217 ENSMUST00000169859.1
 Gm17542
predicted gene, 17542
chr7_-_115846080 0.211 ENSMUST00000166207.1
 Sox6
SRY-box containing gene 6
chr3_+_66985647 0.208 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr3_-_113574242 0.204 ENSMUST00000142505.2
 Amy1
amylase 1, salivary
chr19_+_26748268 0.196 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
 Smarca2




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2




chr6_+_128399881 0.168 ENSMUST00000120405.1
 Nrip2
nuclear receptor interacting protein 2
chr19_+_32619997 0.167 ENSMUST00000025833.6
 Papss2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chrM_+_9452 0.165 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr5_-_110046486 0.164 ENSMUST00000167969.1
 Gm17655
predicted gene, 17655
chr7_+_123123870 0.159 ENSMUST00000094053.5
 Tnrc6a
trinucleotide repeat containing 6a
chr15_-_50889043 0.151 ENSMUST00000183997.1
ENSMUST00000183757.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr16_-_21995478 0.150 ENSMUST00000074230.4
ENSMUST00000060673.6
 Liph

lipase, member H

chrX_-_94212685 0.140 ENSMUST00000050328.8
 Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr19_+_11518493 0.136 ENSMUST00000025580.3
 Ms4a6b
membrane-spanning 4-domains, subfamily A, member 6B
chr6_+_128399766 0.134 ENSMUST00000001561.5
 Nrip2
nuclear receptor interacting protein 2
chr1_-_43827751 0.123 ENSMUST00000128261.1
ENSMUST00000126008.1
ENSMUST00000139451.1
 Uxs1


UDP-glucuronate decarboxylase 1


chr10_+_61175206 0.120 ENSMUST00000079235.5
 Tbata
thymus, brain and testes associated
chr11_-_109472611 0.111 ENSMUST00000168740.1
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr9_-_21760275 0.103 ENSMUST00000098942.4
 Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr7_-_19604444 0.094 ENSMUST00000086041.5
 Clasrp
CLK4-associating serine/arginine rich protein
chr9_-_27155418 0.079 ENSMUST00000167074.1
ENSMUST00000034472.8
 Jam3

junction adhesion molecule 3

chr17_-_78985428 0.075 ENSMUST00000118991.1
 Prkd3
protein kinase D3
chr3_+_136670076 0.071 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr11_-_26210553 0.071 ENSMUST00000101447.3
 5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr18_+_37484955 0.068 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr1_-_191907527 0.065 ENSMUST00000069573.5
 1700034H15Rik
RIKEN cDNA 1700034H15 gene
chrX_-_94212638 0.056 ENSMUST00000113922.1
 Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr7_+_73740277 0.056 ENSMUST00000107456.2
 Fam174b
family with sequence similarity 174, member B
chr1_+_88103229 0.044 ENSMUST00000113135.3
ENSMUST00000113138.1
 Ugt1a6a
Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A6A
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr1_+_88134786 0.043 ENSMUST00000113134.1
ENSMUST00000140092.1
 Ugt1a6a

UDP glucuronosyltransferase 1 family, polypeptide A6A

chr7_+_5020376 0.037 ENSMUST00000076251.4
 Zfp865
zinc finger protein 865
chr11_-_23895208 0.036 ENSMUST00000102863.2
ENSMUST00000020513.3
 Papolg

poly(A) polymerase gamma

chr7_-_24299310 0.032 ENSMUST00000145131.1
 Zfp61
zinc finger protein 61
chr18_-_56572888 0.025 ENSMUST00000174518.1
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr2_-_51149100 0.022 ENSMUST00000154545.1
ENSMUST00000017288.2
 Rnd3

Rho family GTPase 3

chr17_-_35115428 0.022 ENSMUST00000172854.1
ENSMUST00000062657.4
 Ly6g5b

lymphocyte antigen 6 complex, locus G5B

chr1_-_22315792 0.015 ENSMUST00000164877.1
 Rims1
regulating synaptic membrane exocytosis 1
chr4_+_132351768 0.014 ENSMUST00000172202.1
 Gm17300
predicted gene, 17300
chr10_+_5593718 0.009 ENSMUST00000051809.8
 Myct1
myc target 1
chr5_-_23616528 0.005 ENSMUST00000088392.4
 Srpk2
serine/arginine-rich protein specific kinase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 0.9 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 0.2 GO:0034035 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1 0.3 GO:0033762 response to glucagon(GO:0033762)
0.0 0.1 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.0 0.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.8 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.2 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.1 GO:0033010 paranodal junction(GO:0033010)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.2 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.3 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 0.2 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.0 0.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules