Motif ID: Hoxc9

Z-value: 0.745


Transcription factors associated with Hoxc9:

Gene SymbolEntrez IDGene Name
Hoxc9 ENSMUSG00000036139.6 Hoxc9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hoxc9mm10_v2_chr15_+_102977032_1029770320.261.2e-01Click!


Activity profile for motif Hoxc9.

activity profile for motif Hoxc9


Sorted Z-values histogram for motif Hoxc9

Sorted Z-values for motif Hoxc9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_144893127 3.173 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr2_+_70474923 2.849 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr2_-_26516620 2.838 ENSMUST00000132820.1
Notch1
notch 1
chr16_-_37384915 2.811 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l



syntaxin binding protein 5-like



chr1_+_58210397 2.547 ENSMUST00000040442.5
Aox4
aldehyde oxidase 4
chr1_-_45503282 2.373 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr7_-_116038734 2.271 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr14_+_80000292 2.249 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr13_+_94083490 2.216 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr16_-_37384940 2.210 ENSMUST00000114781.1
ENSMUST00000114780.1
Stxbp5l

syntaxin binding protein 5-like

chr4_+_107830958 2.164 ENSMUST00000106731.2
Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr8_-_120228221 2.099 ENSMUST00000183235.1
A330074K22Rik
RIKEN cDNA A330074K22 gene
chr9_+_35423582 1.679 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr2_+_4300462 1.609 ENSMUST00000175669.1
Frmd4a
FERM domain containing 4A
chr4_-_91376433 1.546 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr2_+_102658640 1.527 ENSMUST00000080210.3
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chrX_-_105928547 1.518 ENSMUST00000101305.2
Atrx
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
chr4_+_100776664 1.472 ENSMUST00000030257.8
ENSMUST00000097955.2
Cachd1

cache domain containing 1

chr10_-_92162753 1.426 ENSMUST00000182197.1
Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chrX_-_141474034 1.317 ENSMUST00000101205.2
Col4a6
collagen, type IV, alpha 6
chr4_-_91376490 1.239 ENSMUST00000107124.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr18_+_65582239 1.215 ENSMUST00000182684.1
Zfp532
zinc finger protein 532
chr2_+_91256144 1.118 ENSMUST00000154959.1
ENSMUST00000059566.4
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr3_+_66985680 1.085 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr18_+_65582281 1.044 ENSMUST00000183319.1
Zfp532
zinc finger protein 532
chr17_-_57000018 1.041 ENSMUST00000002740.2
Pspn
persephin
chr17_+_24426676 0.979 ENSMUST00000024946.5
Eci1
enoyl-Coenzyme A delta isomerase 1
chr11_+_3330401 0.976 ENSMUST00000045153.4
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr11_-_80080928 0.955 ENSMUST00000103233.3
ENSMUST00000061283.8
Crlf3

cytokine receptor-like factor 3

chr5_-_44101668 0.884 ENSMUST00000087441.4
ENSMUST00000074113.6
Prom1

prominin 1

chr2_-_84650714 0.790 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr17_-_49564262 0.781 ENSMUST00000057610.6
Daam2
dishevelled associated activator of morphogenesis 2
chr2_+_175010241 0.763 ENSMUST00000109069.1
ENSMUST00000109070.2
Gm14444

predicted gene 14444

chr2_-_177578199 0.758 ENSMUST00000108945.1
ENSMUST00000108943.1
Gm14406

predicted gene 14406

chr2_-_84650760 0.707 ENSMUST00000111691.1
Ctnnd1
catenin (cadherin associated protein), delta 1
chr18_+_65582390 0.705 ENSMUST00000169679.1
ENSMUST00000183326.1
Zfp532

zinc finger protein 532

chr10_-_13324160 0.670 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr2_+_128967383 0.664 ENSMUST00000110320.2
ENSMUST00000110319.2
Zc3h6

zinc finger CCCH type containing 6

chr2_-_84650490 0.636 ENSMUST00000066177.3
Ctnnd1
catenin (cadherin associated protein), delta 1
chr2_-_84650676 0.636 ENSMUST00000067232.3
Ctnnd1
catenin (cadherin associated protein), delta 1
chr2_-_91255995 0.634 ENSMUST00000180732.1
Gm17281
predicted gene, 17281
chr4_-_150003130 0.581 ENSMUST00000084117.6
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr9_-_7835255 0.571 ENSMUST00000074246.6
Birc2
baculoviral IAP repeat-containing 2
chr10_-_13324250 0.546 ENSMUST00000105543.1
Phactr2
phosphatase and actin regulator 2
chrX_-_143933089 0.532 ENSMUST00000087313.3
Dcx
doublecortin
chr2_+_91255954 0.481 ENSMUST00000134699.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chrX_+_56609751 0.473 ENSMUST00000144068.1
Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chrX_-_37104523 0.437 ENSMUST00000130324.1
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr7_-_30612731 0.362 ENSMUST00000006476.4
Upk1a
uroplakin 1A
chr11_-_94242701 0.357 ENSMUST00000061469.3
Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr11_+_85353156 0.333 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
Bcas3





breast carcinoma amplified sequence 3





chr19_-_10880370 0.306 ENSMUST00000133303.1
Tmem109
transmembrane protein 109
chr6_-_119388671 0.271 ENSMUST00000169744.1
Adipor2
adiponectin receptor 2
chr4_+_137594140 0.242 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
Usp48



ubiquitin specific peptidase 48



chr5_+_67260696 0.212 ENSMUST00000161233.1
ENSMUST00000160352.1
Tmem33

transmembrane protein 33

chr6_+_125145235 0.155 ENSMUST00000119527.1
ENSMUST00000088276.6
ENSMUST00000051171.7
ENSMUST00000117675.1
Iffo1



intermediate filament family orphan 1



chr2_-_128967725 0.128 ENSMUST00000099385.2
Gm10762
predicted gene 10762
chr3_+_66985700 0.126 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr9_-_89705017 0.120 ENSMUST00000058488.6
Tmed3
transmembrane emp24 domain containing 3
chr13_+_113209659 0.112 ENSMUST00000038144.8
Esm1
endothelial cell-specific molecule 1
chr11_-_72215592 0.108 ENSMUST00000021157.8
Med31
mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)
chr3_+_66985647 0.072 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr13_+_58281183 0.072 ENSMUST00000180882.1
ENSMUST00000180452.1
Gm26555

predicted gene, 26555

chr10_-_88605017 0.061 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr2_+_3513035 0.058 ENSMUST00000036350.2
Cdnf
cerebral dopamine neurotrophic factor
chr3_-_33844255 0.030 ENSMUST00000029222.5
Ccdc39
coiled-coil domain containing 39

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
0.8 2.5 GO:0046110 xanthine metabolic process(GO:0046110)
0.8 2.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.6 2.8 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.4 1.5 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.3 1.0 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3 0.9 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.3 3.2 GO:0042572 retinol metabolic process(GO:0042572)
0.2 2.2 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.2 1.5 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 1.7 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.2 2.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 0.6 GO:1902527 positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527)
0.1 2.8 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 5.0 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 1.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 1.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.0 2.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 1.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.6 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.3 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0 0.3 GO:0061042 vascular wound healing(GO:0061042)
0.0 1.3 GO:0046677 response to antibiotic(GO:0046677)
0.0 1.0 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.0 0.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.3 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 2.8 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 1.0 GO:0001658 branching involved in ureteric bud morphogenesis(GO:0001658)
0.0 0.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.3 GO:0071480 cellular response to gamma radiation(GO:0071480)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0005588 collagen type V trimer(GO:0005588)
0.6 2.8 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.4 1.5 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.3 0.9 GO:0071914 prominosome(GO:0071914)
0.3 1.3 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3 2.8 GO:0005915 zonula adherens(GO:0005915)
0.2 2.2 GO:0042581 specific granule(GO:0042581)
0.1 0.3 GO:0044308 axonal spine(GO:0044308)
0.0 1.5 GO:0030673 axolemma(GO:0030673)
0.0 0.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.1 GO:0005859 muscle myosin complex(GO:0005859)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0030151 molybdenum ion binding(GO:0030151)
0.5 2.2 GO:0038025 reelin receptor activity(GO:0038025)
0.5 3.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 1.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.3 1.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 1.5 GO:0015616 DNA translocase activity(GO:0015616)
0.2 1.0 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.2 0.6 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 0.6 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 1.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.3 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 2.8 GO:0005112 Notch binding(GO:0005112)
0.1 0.3 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 2.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 5.0 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.9 GO:0042805 actinin binding(GO:0042805)
0.0 1.1 GO:0008083 growth factor activity(GO:0008083)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.8 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 2.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.6 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 3.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 1.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 3.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.6 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions