Motif ID: Hoxc9

Z-value: 0.745


Transcription factors associated with Hoxc9:

Gene SymbolEntrez IDGene Name
Hoxc9 ENSMUSG00000036139.6 Hoxc9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hoxc9mm10_v2_chr15_+_102977032_1029770320.261.2e-01Click!


Activity profile for motif Hoxc9.

activity profile for motif Hoxc9


Sorted Z-values histogram for motif Hoxc9

Sorted Z-values for motif Hoxc9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc9

PNG image of the network

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Top targets:


Showing 1 to 20 of 66 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144893127 3.173 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr2_+_70474923 2.849 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr2_-_26516620 2.838 ENSMUST00000132820.1
 Notch1
notch 1
chr16_-_37384915 2.811 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr1_+_58210397 2.547 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr1_-_45503282 2.373 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr7_-_116038734 2.271 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr14_+_80000292 2.249 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr13_+_94083490 2.216 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr16_-_37384940 2.210 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr4_+_107830958 2.164 ENSMUST00000106731.2
 Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr8_-_120228221 2.099 ENSMUST00000183235.1
 A330074K22Rik
RIKEN cDNA A330074K22 gene
chr9_+_35423582 1.679 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr2_+_4300462 1.609 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr4_-_91376433 1.546 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr2_+_102658640 1.527 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chrX_-_105928547 1.518 ENSMUST00000101305.2
 Atrx
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
chr4_+_100776664 1.472 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr10_-_92162753 1.426 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chrX_-_141474034 1.317 ENSMUST00000101205.2
 Col4a6
collagen, type IV, alpha 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.3 3.2 GO:0042572 retinol metabolic process(GO:0042572)
0.9 2.8 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
0.6 2.8 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.1 2.8 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 2.8 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.8 2.5 GO:0046110 xanthine metabolic process(GO:0046110)
0.8 2.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 2.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 2.2 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 2.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 1.7 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 1.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.4 1.5 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.2 1.5 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 1.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 1.3 GO:0046677 response to antibiotic(GO:0046677)
0.3 1.0 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 1.0 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.8 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.3 2.8 GO:0005915 zonula adherens(GO:0005915)
0.8 2.4 GO:0005588 collagen type V trimer(GO:0005588)
0.2 2.2 GO:0042581 specific granule(GO:0042581)
0.4 1.5 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0 1.5 GO:0030673 axolemma(GO:0030673)
0.3 1.3 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3 0.9 GO:0071914 prominosome(GO:0071914)
0.0 0.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.3 GO:0044308 axonal spine(GO:0044308)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0005859 muscle myosin complex(GO:0005859)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0019905 syntaxin binding(GO:0019905)
0.5 3.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 2.8 GO:0005112 Notch binding(GO:0005112)
0.6 2.5 GO:0030151 molybdenum ion binding(GO:0030151)
0.1 2.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 2.2 GO:0038025 reelin receptor activity(GO:0038025)
0.1 1.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.3 1.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 1.5 GO:0015616 DNA translocase activity(GO:0015616)
0.0 1.1 GO:0008083 growth factor activity(GO:0008083)
0.3 1.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 1.0 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.9 GO:0042805 actinin binding(GO:0042805)
0.2 0.6 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 0.6 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.3 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.3 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 NABA_COLLAGENS Genes encoding collagen proteins
0.0 3.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.8 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 2.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.2 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 1.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.6 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions