Motif ID: Hoxd10

Z-value: 0.344


Transcription factors associated with Hoxd10:

Gene SymbolEntrez IDGene Name
Hoxd10 ENSMUSG00000050368.3 Hoxd10



Activity profile for motif Hoxd10.

activity profile for motif Hoxd10


Sorted Z-values histogram for motif Hoxd10

Sorted Z-values for motif Hoxd10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd10

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_27790947 3.058 ENSMUST00000115243.2
Opcml
opioid binding protein/cell adhesion molecule-like
chr8_-_84773381 2.231 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr4_+_102254993 1.289 ENSMUST00000106908.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr3_+_86084434 1.258 ENSMUST00000107664.2
Sh3d19
SH3 domain protein D19
chr3_-_80802789 1.177 ENSMUST00000107745.1
ENSMUST00000075316.4
Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr2_+_65620829 0.853 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr1_-_152625212 0.840 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr17_-_78684262 0.752 ENSMUST00000145480.1
Strn
striatin, calmodulin binding protein
chr9_-_90255927 0.742 ENSMUST00000144646.1
Tbc1d2b
TBC1 domain family, member 2B
chr7_+_96210107 0.714 ENSMUST00000138760.1
Tenm4
teneurin transmembrane protein 4
chrX_+_66653003 0.677 ENSMUST00000036043.4
Slitrk2
SLIT and NTRK-like family, member 2
chr10_+_69534039 0.576 ENSMUST00000182557.1
Ank3
ankyrin 3, epithelial
chr10_+_116177351 0.568 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr

protein tyrosine phosphatase, receptor type, R

chrX_-_70365052 0.550 ENSMUST00000101509.2
Ids
iduronate 2-sulfatase
chr4_+_43401232 0.489 ENSMUST00000125399.1
Rusc2
RUN and SH3 domain containing 2
chr11_-_110168073 0.479 ENSMUST00000044850.3
Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr2_+_106693185 0.449 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr15_+_9140527 0.448 ENSMUST00000090380.4
Lmbrd2
LMBR1 domain containing 2
chr3_+_55461758 0.447 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr13_+_40917626 0.340 ENSMUST00000067778.6
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr6_+_33249085 0.320 ENSMUST00000052266.8
ENSMUST00000090381.4
ENSMUST00000115080.1
Exoc4


exocyst complex component 4


chr17_+_71204647 0.288 ENSMUST00000126681.1
Lpin2
lipin 2
chr1_+_180111339 0.188 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr1_-_45503282 0.188 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr6_-_92481343 0.187 ENSMUST00000113445.1
Prickle2
prickle homolog 2 (Drosophila)
chr9_+_104569671 0.171 ENSMUST00000057742.8
Cpne4
copine IV
chr19_+_37436707 0.123 ENSMUST00000128184.1
Hhex
hematopoietically expressed homeobox
chr17_+_78508063 0.121 ENSMUST00000024880.9
Vit
vitrin
chr8_-_109251698 0.118 ENSMUST00000079189.3
4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr14_-_93888732 0.101 ENSMUST00000068992.2
Pcdh9
protocadherin 9
chr18_-_78123324 0.076 ENSMUST00000160292.1
ENSMUST00000091813.5
Slc14a1

solute carrier family 14 (urea transporter), member 1

chrX_-_74246534 0.073 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna

filamin, alpha

chr5_+_121777929 0.070 ENSMUST00000160821.1
Atxn2
ataxin 2
chr7_+_30095150 0.066 ENSMUST00000130526.1
ENSMUST00000108200.1
Zfp260

zinc finger protein 260

chr1_-_132390301 0.054 ENSMUST00000132435.1
Tmcc2
transmembrane and coiled-coil domains 2
chr9_+_95857597 0.050 ENSMUST00000034980.7
Atr
ataxia telangiectasia and Rad3 related
chr6_-_28397999 0.049 ENSMUST00000035930.4
Zfp800
zinc finger protein 800
chr15_-_103215285 0.039 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
Cbx5


chromobox 5


chr5_-_92328068 0.030 ENSMUST00000113093.3
Cxcl9
chemokine (C-X-C motif) ligand 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.1 0.6 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 2.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 1.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.2 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.1 0.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 1.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.6 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.3 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 1.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.1 GO:0061010 gall bladder development(GO:0061010)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.1 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.8 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 1.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.5 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 1.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0015265 urea channel activity(GO:0015265)
0.0 0.1 GO:0008301 DNA binding, bending(GO:0008301)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.8 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.5 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.3 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing