Motif ID: Hoxd11_Cdx1_Hoxc11

Z-value: 0.659

Transcription factors associated with Hoxd11_Cdx1_Hoxc11:

Gene SymbolEntrez IDGene Name
Cdx1 ENSMUSG00000024619.8 Cdx1
Hoxc11 ENSMUSG00000001656.3 Hoxc11
Hoxd11 ENSMUSG00000042499.12 Hoxd11



Activity profile for motif Hoxd11_Cdx1_Hoxc11.

activity profile for motif Hoxd11_Cdx1_Hoxc11


Sorted Z-values histogram for motif Hoxd11_Cdx1_Hoxc11

Sorted Z-values for motif Hoxd11_Cdx1_Hoxc11



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd11_Cdx1_Hoxc11

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_84064772 7.077 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr4_+_144893127 6.355 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_-_154636831 4.766 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr4_+_144892813 4.292 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr3_-_49757257 3.410 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr15_+_25773985 3.328 ENSMUST00000125667.1
 Myo10
myosin X
chr4_+_144893077 3.237 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr17_+_3397189 3.033 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr3_+_62419668 2.615 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr1_+_159737510 2.444 ENSMUST00000111669.3
 Tnr
tenascin R
chr1_+_19103022 2.268 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr3_+_66985680 2.131 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr5_-_62766153 2.054 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_+_69593361 2.047 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4

chr1_-_56969864 2.004 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr7_-_142661858 1.997 ENSMUST00000145896.2
 Igf2
insulin-like growth factor 2
chr17_-_35074485 1.868 ENSMUST00000007259.3
 Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr1_-_56969827 1.750 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr9_+_62858085 1.715 ENSMUST00000034777.6
ENSMUST00000163820.1
 Calml4

calmodulin-like 4

chr6_+_80018877 1.637 ENSMUST00000147663.1
ENSMUST00000128718.1
ENSMUST00000126005.1
ENSMUST00000133918.1
 Lrrtm4



leucine rich repeat transmembrane neuronal 4




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 13.9 GO:0042572 retinol metabolic process(GO:0042572)
0.6 4.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.3 3.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 3.6 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 3.3 GO:0046677 response to antibiotic(GO:0046677)
0.1 3.3 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 2.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.6 2.4 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.2 2.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 2.0 GO:0042118 endothelial cell activation(GO:0042118)
0.0 2.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 1.9 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 1.6 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 1.6 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.5 1.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 1.4 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 1.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.2 GO:0048664 neuron fate determination(GO:0048664)
0.1 1.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.1 GO:0030903 notochord development(GO:0030903)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0016235 aggresome(GO:0016235)
0.0 4.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.5 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 3.3 GO:0016459 myosin complex(GO:0016459)
0.8 2.4 GO:0072534 perineuronal net(GO:0072534)
0.1 1.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.5 1.4 GO:0005588 collagen type V trimer(GO:0005588)
0.0 1.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 1.0 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 1.0 GO:0005614 interstitial matrix(GO:0005614)
0.2 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 0.9 GO:0070820 tertiary granule(GO:0070820)
0.0 0.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)
0.0 0.5 GO:0044306 neuron projection terminus(GO:0044306)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 13.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 4.7 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 3.8 GO:0030507 spectrin binding(GO:0030507)
0.0 3.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 2.4 GO:0046625 sphingolipid binding(GO:0046625)
0.1 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 2.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 2.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 1.9 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 1.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.2 GO:0071837 HMG box domain binding(GO:0071837)
0.2 1.0 GO:0045545 syndecan binding(GO:0045545)
0.2 1.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.9 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.3 0.8 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 0.8 GO:0043125 ErbB-3 class receptor binding(GO:0043125)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 3.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.1 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 3.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.9 PID_ARF6_PATHWAY Arf6 signaling events
0.1 2.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.4 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.6 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 0.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.5 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 0.4 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 0.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.2 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 3.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 2.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.9 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 0.9 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 0.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.8 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.5 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling