Motif ID: Hoxd12

Z-value: 1.247


Transcription factors associated with Hoxd12:

Gene SymbolEntrez IDGene Name
Hoxd12 ENSMUSG00000001823.4 Hoxd12



Activity profile for motif Hoxd12.

activity profile for motif Hoxd12


Sorted Z-values histogram for motif Hoxd12

Sorted Z-values for motif Hoxd12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd12

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_84064772 15.387 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr1_-_56969864 11.362 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr15_-_8710734 11.187 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_+_144893127 10.491 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 10.275 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_-_154636831 9.751 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
Prdm16






PR domain containing 16






chr15_-_8710409 8.844 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_56969827 8.047 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr4_+_144893077 7.968 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr16_+_42907563 7.659 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr1_+_159737510 6.358 ENSMUST00000111669.3
Tnr
tenascin R
chr1_+_19103022 6.071 ENSMUST00000037294.7
Tfap2d
transcription factor AP-2, delta
chr6_+_125215551 4.373 ENSMUST00000032487.7
ENSMUST00000100942.2
ENSMUST00000063588.8
Vamp1


vesicle-associated membrane protein 1


chr9_-_77347816 4.047 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
Mlip



muscular LMNA-interacting protein



chr5_-_62766153 3.592 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_9403049 3.447 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
C030034L19Rik


RIKEN cDNA C030034L19 gene


chr9_-_77347787 3.400 ENSMUST00000184848.1
ENSMUST00000184415.1
Mlip

muscular LMNA-interacting protein

chr13_-_101692624 3.115 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr17_+_3397189 3.056 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr1_-_45503282 3.013 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr19_+_55741810 2.933 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr1_-_152625212 2.905 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr4_-_88033328 2.888 ENSMUST00000078090.5
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_-_165934900 2.836 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr13_-_97747373 2.780 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747399 2.742 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr18_-_35215008 2.550 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr2_+_73271925 2.416 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr3_+_66985680 2.239 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr9_-_77347889 2.238 ENSMUST00000185039.1
Mlip
muscular LMNA-interacting protein
chr19_-_6987621 2.195 ENSMUST00000130048.1
ENSMUST00000025914.6
Vegfb

vascular endothelial growth factor B

chr9_+_62858085 2.162 ENSMUST00000034777.6
ENSMUST00000163820.1
Calml4

calmodulin-like 4

chr1_-_163313661 1.975 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr17_+_57358682 1.886 ENSMUST00000086763.5
ENSMUST00000004850.7
Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chr10_-_30655859 1.862 ENSMUST00000092610.4
Ncoa7
nuclear receptor coactivator 7
chr2_-_36104060 1.690 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr3_+_122419772 1.668 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr5_+_107497762 1.639 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr11_-_118355496 1.623 ENSMUST00000017610.3
Timp2
tissue inhibitor of metalloproteinase 2
chr11_-_109473220 1.621 ENSMUST00000070872.6
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr1_+_81077274 1.515 ENSMUST00000068275.5
ENSMUST00000113494.2
Nyap2

neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2

chr1_+_81077204 1.509 ENSMUST00000123720.1
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr5_-_62765618 1.508 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_+_107497718 1.502 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr3_-_87768932 1.387 ENSMUST00000173184.1
ENSMUST00000172621.1
ENSMUST00000174759.1
ENSMUST00000172590.1
ENSMUST00000079083.5
Pear1




platelet endothelial aggregation receptor 1




chr15_+_81936753 1.326 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr4_-_82505749 1.311 ENSMUST00000107245.2
ENSMUST00000107246.1
Nfib

nuclear factor I/B

chr5_+_19907502 1.306 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr18_-_20002093 1.232 ENSMUST00000115848.3
Dsc3
desmocollin 3
chr14_+_66868850 1.206 ENSMUST00000100453.1
Gm5464
predicted gene 5464
chr2_-_45117349 1.203 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr17_-_35897073 1.200 ENSMUST00000150056.1
ENSMUST00000156817.1
ENSMUST00000146451.1
ENSMUST00000148482.1
2310061I04Rik



RIKEN cDNA 2310061I04 gene



chr4_-_82505707 1.186 ENSMUST00000107248.1
ENSMUST00000107247.1
Nfib

nuclear factor I/B

chr6_+_15185203 1.167 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr6_-_119388671 1.167 ENSMUST00000169744.1
Adipor2
adiponectin receptor 2
chr4_+_136284708 1.162 ENSMUST00000130223.1
Zfp46
zinc finger protein 46
chr10_+_90071095 1.154 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr7_-_100583072 1.149 ENSMUST00000152876.1
ENSMUST00000150042.1
Mrpl48

mitochondrial ribosomal protein L48

chr12_+_55836365 1.125 ENSMUST00000059250.6
Brms1l
breast cancer metastasis-suppressor 1-like
chr16_+_11405648 1.121 ENSMUST00000096273.2
Snx29
sorting nexin 29
chr19_+_60755947 1.108 ENSMUST00000088237.4
Nanos1
nanos homolog 1 (Drosophila)
chr4_+_136284658 1.104 ENSMUST00000144217.1
Zfp46
zinc finger protein 46
chr17_-_51826562 1.099 ENSMUST00000024720.4
ENSMUST00000129667.1
ENSMUST00000156051.1
ENSMUST00000169480.1
ENSMUST00000148559.1
Satb1




special AT-rich sequence binding protein 1




chr4_-_11981265 1.078 ENSMUST00000098260.2
Gm10604
predicted gene 10604
chr3_+_66985647 1.012 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr4_+_31964081 0.994 ENSMUST00000037607.4
ENSMUST00000080933.6
ENSMUST00000108183.1
ENSMUST00000108184.2
Map3k7



mitogen-activated protein kinase kinase kinase 7



chr13_+_80883403 0.973 ENSMUST00000099356.2
Arrdc3
arrestin domain containing 3
chr3_+_66985700 0.956 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr1_+_63176818 0.954 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chrM_+_3906 0.936 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr14_-_118052235 0.929 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr8_+_69902178 0.902 ENSMUST00000050373.5
Tssk6
testis-specific serine kinase 6
chr3_+_66985947 0.858 ENSMUST00000161726.1
ENSMUST00000160504.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr3_+_41024369 0.854 ENSMUST00000099121.3
Larp1b
La ribonucleoprotein domain family, member 1B
chr8_+_25720054 0.807 ENSMUST00000068916.8
ENSMUST00000139836.1
Ppapdc1b

phosphatidic acid phosphatase type 2 domain containing 1B

chr17_-_91092715 0.789 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr8_-_47352348 0.768 ENSMUST00000110367.2
Stox2
storkhead box 2
chrX_+_56779437 0.758 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chrX_+_140456613 0.744 ENSMUST00000033809.3
Prps1
phosphoribosyl pyrophosphate synthetase 1
chr13_-_56895737 0.697 ENSMUST00000022023.6
ENSMUST00000109871.1
Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr7_+_81213567 0.693 ENSMUST00000026672.7
Pde8a
phosphodiesterase 8A
chr1_+_153874335 0.690 ENSMUST00000055314.3
Gm5531
predicted gene 5531
chr4_-_82850721 0.660 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr2_-_66410064 0.638 ENSMUST00000112366.1
Scn1a
sodium channel, voltage-gated, type I, alpha
chr5_-_74531619 0.629 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Scfd2



Sec1 family domain containing 2



chr17_+_91236787 0.628 ENSMUST00000057074.8
Gm6741
predicted gene 6741
chr16_-_35769356 0.628 ENSMUST00000023554.8
Dirc2
disrupted in renal carcinoma 2 (human)
chr18_-_15063560 0.605 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr15_+_81936911 0.596 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr9_-_13245741 0.574 ENSMUST00000110582.2
Jrkl
jerky homolog-like (mouse)
chr5_-_24030649 0.557 ENSMUST00000030849.6
Fam126a
family with sequence similarity 126, member A
chr1_-_44118757 0.529 ENSMUST00000027213.7
ENSMUST00000065767.2
Kdelc1

KDEL (Lys-Asp-Glu-Leu) containing 1

chr14_-_36919513 0.527 ENSMUST00000182042.1
Ccser2
coiled-coil serine rich 2
chr13_-_18382041 0.517 ENSMUST00000139064.2
ENSMUST00000175703.2
Pou6f2

POU domain, class 6, transcription factor 2

chr3_-_126998408 0.502 ENSMUST00000182764.1
ENSMUST00000044443.8
Ank2

ankyrin 2, brain

chr11_-_109472611 0.493 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr3_-_141931523 0.473 ENSMUST00000106232.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr9_+_120929216 0.427 ENSMUST00000130466.1
Ctnnb1
catenin (cadherin associated protein), beta 1
chr14_-_36919314 0.402 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr18_-_37020679 0.384 ENSMUST00000097612.2
Gm10545
predicted gene 10545
chr3_+_108591279 0.366 ENSMUST00000051145.8
ENSMUST00000139626.1
Wdr47

WD repeat domain 47

chr4_+_148000722 0.359 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr5_-_24842579 0.356 ENSMUST00000030787.8
Rheb
Ras homolog enriched in brain
chr1_-_128102412 0.353 ENSMUST00000112538.1
ENSMUST00000086614.5
Zranb3

zinc finger, RAN-binding domain containing 3

chr12_+_33147754 0.349 ENSMUST00000146040.1
ENSMUST00000125192.1
Atxn7l1

ataxin 7-like 1

chr13_-_99344652 0.321 ENSMUST00000022153.6
Ptcd2
pentatricopeptide repeat domain 2
chr19_-_45812291 0.313 ENSMUST00000086993.4
Kcnip2
Kv channel-interacting protein 2
chr10_+_116177351 0.290 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr

protein tyrosine phosphatase, receptor type, R

chr17_+_34263209 0.286 ENSMUST00000040828.5
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr8_-_69902558 0.268 ENSMUST00000110167.3
Ndufa13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr1_-_63176653 0.240 ENSMUST00000027111.8
ENSMUST00000168099.2
Ndufs1

NADH dehydrogenase (ubiquinone) Fe-S protein 1

chr12_-_73047179 0.239 ENSMUST00000050029.7
Six1
sine oculis-related homeobox 1
chr14_+_32085804 0.231 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
Oxnad1


oxidoreductase NAD-binding domain containing 1


chr7_+_30565410 0.228 ENSMUST00000043850.7
Igflr1
IGF-like family receptor 1
chr17_+_73804841 0.209 ENSMUST00000024860.7
Ehd3
EH-domain containing 3
chr14_-_66868572 0.206 ENSMUST00000022629.8
Dpysl2
dihydropyrimidinase-like 2
chr3_-_19163011 0.201 ENSMUST00000029125.8
Armc1
armadillo repeat containing 1
chr4_-_92191749 0.162 ENSMUST00000123179.1
Gm12666
predicted gene 12666
chr10_+_42583787 0.138 ENSMUST00000105497.1
ENSMUST00000144806.1
Ostm1

osteopetrosis associated transmembrane protein 1

chr19_-_47464406 0.115 ENSMUST00000111800.2
ENSMUST00000081619.2
Sh3pxd2a

SH3 and PX domains 2A

chr16_+_65520503 0.062 ENSMUST00000176330.1
ENSMUST00000004964.8
ENSMUST00000176038.1
Pou1f1


POU domain, class 1, transcription factor 1


chrM_+_7759 0.054 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr13_-_23622502 0.049 ENSMUST00000062045.2
Hist1h1e
histone cluster 1, H1e
chr15_+_81744848 0.032 ENSMUST00000109554.1
Zc3h7b
zinc finger CCCH type containing 7B
chr2_-_180824596 0.014 ENSMUST00000148700.1
Gm14340
predicted gene 14340

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 20.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
2.6 28.7 GO:0042572 retinol metabolic process(GO:0042572)
1.6 6.4 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.2 9.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
1.2 19.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.0 3.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.6 2.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.5 2.2 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.4 3.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.4 3.4 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.3 1.7 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.3 1.0 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.3 3.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.3 1.6 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.3 2.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 0.7 GO:0046101 hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.2 9.7 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 1.2 GO:0061042 vascular wound healing(GO:0061042)
0.2 1.4 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.2 4.4 GO:0035493 SNARE complex assembly(GO:0035493)
0.2 1.2 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 1.0 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.2 7.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 1.9 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.2 2.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 0.9 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 5.1 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.5 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.4 GO:0036292 DNA rewinding(GO:0036292)
0.1 0.9 GO:0035092 sperm chromatin condensation(GO:0035092)
0.1 1.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 2.5 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 0.4 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.3 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 1.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 2.0 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.1 1.7 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.3 GO:0002339 B cell selection(GO:0002339)
0.1 0.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 1.1 GO:1900153 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.4 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 2.0 GO:0030901 midbrain development(GO:0030901)
0.0 0.7 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.7 GO:1901032 negative regulation of response to reactive oxygen species(GO:1901032) negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 0.2 GO:1901387 Golgi to lysosome transport(GO:0090160) positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.0 0.1 GO:0072675 osteoclast fusion(GO:0072675)
0.0 1.9 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.1 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.0 0.2 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.0 0.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.0 GO:0045471 response to ethanol(GO:0045471)
0.0 0.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 2.2 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.0 2.1 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 1.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.1 GO:0016575 histone deacetylation(GO:0016575)
0.0 1.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.4 GO:0072534 perineuronal net(GO:0072534)
1.0 3.0 GO:0005588 collagen type V trimer(GO:0005588)
0.9 4.4 GO:0070820 tertiary granule(GO:0070820)
0.4 3.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 2.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 9.8 GO:0016235 aggresome(GO:0016235)
0.2 20.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 0.7 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.2 1.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 3.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 10.8 GO:0016605 PML body(GO:0016605)
0.1 1.2 GO:0030057 desmosome(GO:0030057)
0.1 20.0 GO:0043197 dendritic spine(GO:0043197)
0.1 0.2 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 1.4 GO:0001891 phagocytic cup(GO:0001891)
0.1 2.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.4 GO:0042629 mast cell granule(GO:0042629)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.5 GO:0031430 M band(GO:0031430)
0.0 0.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 3.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.4 GO:0070469 respiratory chain(GO:0070469)
0.0 0.9 GO:0015630 microtubule cytoskeleton(GO:0015630)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 28.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
3.3 20.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.8 3.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.7 2.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.5 2.9 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.4 6.4 GO:0046625 sphingolipid binding(GO:0046625)
0.3 1.2 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.2 1.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 4.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 0.8 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 0.7 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 2.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 14.5 GO:0046332 SMAD binding(GO:0046332)
0.1 2.8 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 2.0 GO:0071837 HMG box domain binding(GO:0071837)
0.1 5.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 4.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 2.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 5.8 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 1.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.0 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 0.4 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.5 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.6 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.3 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.4 GO:0036310 annealing helicase activity(GO:0036310)
0.0 1.1 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 3.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 15.5 GO:0003682 chromatin binding(GO:0003682)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 1.5 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 6.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 26.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 2.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.2 3.1 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 5.1 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.0 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 3.0 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 3.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 6.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID_BMP_PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 20.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 4.4 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.3 3.1 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.2 2.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 5.3 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.1 0.7 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.0 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 1.6 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.3 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 7.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.7 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression