Motif ID: Hoxd8

Z-value: 0.781


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

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Top targets:


Showing 1 to 20 of 81 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_138848576 5.582 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr9_+_80165013 4.599 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr3_+_127633134 3.958 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr9_+_80165079 3.592 ENSMUST00000184480.1
 Myo6
myosin VI
chr6_+_34384218 3.582 ENSMUST00000038383.7
ENSMUST00000115051.1
 Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

chr3_+_94372794 2.781 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr3_+_76075583 2.621 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr4_+_118961578 2.542 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr4_-_132398199 2.510 ENSMUST00000136711.1
ENSMUST00000084249.4
 Phactr4

phosphatase and actin regulator 4

chr5_-_111761697 2.418 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr1_-_172027269 2.345 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr15_-_35155750 2.131 ENSMUST00000067033.7
ENSMUST00000018476.7
 Stk3

serine/threonine kinase 3

chr18_+_11633276 2.130 ENSMUST00000115861.2
 Rbbp8
retinoblastoma binding protein 8
chr6_+_71282280 2.004 ENSMUST00000080949.7
 Krcc1
lysine-rich coiled-coil 1
chr19_+_23723279 1.840 ENSMUST00000067077.1
 Gm9938
predicted gene 9938
chr2_+_83724397 1.822 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
 Itgav


integrin alpha V


chr5_+_92809372 1.821 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr2_-_160619971 1.743 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr12_-_84617326 1.731 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr5_-_62766153 1.697 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.2 GO:0071257 cellular response to electrical stimulus(GO:0071257)
1.5 7.4 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 4.0 GO:0021954 central nervous system neuron development(GO:0021954)
0.3 2.8 GO:0072615 interleukin-17 secretion(GO:0072615)
0.6 2.5 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 2.5 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.8 2.3 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.5 2.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.4 2.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 2.0 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 1.8 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.3 1.7 GO:0009235 cobalamin metabolic process(GO:0009235)
0.4 1.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 1.3 GO:0060349 bone morphogenesis(GO:0060349)
0.2 1.2 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.2 0.9 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.2 0.9 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.9 GO:2000780 negative regulation of double-strand break repair(GO:2000780)
0.2 0.8 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.7 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.6 2.3 GO:0060187 cell pole(GO:0060187)
0.0 2.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.6 1.8 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 1.8 GO:0043296 apical junction complex(GO:0043296)
0.0 1.1 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.9 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.2 0.7 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.2 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 GO:0003774 motor activity(GO:0003774)
0.1 4.0 GO:0070888 E-box binding(GO:0070888)
0.7 3.6 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.7 2.8 GO:0008142 oxysterol binding(GO:0008142)
0.8 2.5 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.5 2.5 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.2 2.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 2.1 GO:0002039 p53 binding(GO:0002039)
0.0 2.1 GO:0000287 magnesium ion binding(GO:0000287)
0.4 1.8 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.0 1.8 GO:0051015 actin filament binding(GO:0051015)
0.1 1.7 GO:0005402 cation:sugar symporter activity(GO:0005402)
0.1 1.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.4 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.3 1.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.9 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.7 GO:0015129 lactate transmembrane transporter activity(GO:0015129)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 2.1 PID_BARD1_PATHWAY BARD1 signaling events
0.1 1.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.6 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 2.2 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 2.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 2.1 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 1.8 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.7 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 1.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex