Motif ID: Hoxd8

Z-value: 0.781


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_138848576 5.582 ENSMUST00000112030.2
Lhx9
LIM homeobox protein 9
chr9_+_80165013 4.599 ENSMUST00000035889.8
ENSMUST00000113268.1
Myo6

myosin VI

chr3_+_127633134 3.958 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr9_+_80165079 3.592 ENSMUST00000184480.1
Myo6
myosin VI
chr6_+_34384218 3.582 ENSMUST00000038383.7
ENSMUST00000115051.1
Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

chr3_+_94372794 2.781 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr3_+_76075583 2.621 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr4_+_118961578 2.542 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1
chr4_-_132398199 2.510 ENSMUST00000136711.1
ENSMUST00000084249.4
Phactr4

phosphatase and actin regulator 4

chr5_-_111761697 2.418 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr1_-_172027269 2.345 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr15_-_35155750 2.131 ENSMUST00000067033.7
ENSMUST00000018476.7
Stk3

serine/threonine kinase 3

chr18_+_11633276 2.130 ENSMUST00000115861.2
Rbbp8
retinoblastoma binding protein 8
chr6_+_71282280 2.004 ENSMUST00000080949.7
Krcc1
lysine-rich coiled-coil 1
chr19_+_23723279 1.840 ENSMUST00000067077.1
Gm9938
predicted gene 9938
chr2_+_83724397 1.822 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
Itgav


integrin alpha V


chr5_+_92809372 1.821 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr2_-_160619971 1.743 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr12_-_84617326 1.731 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr5_-_62766153 1.697 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_158814469 1.349 ENSMUST00000161589.2
Pappa2
pappalysin 2
chr17_-_48432723 1.344 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr8_-_84662841 1.251 ENSMUST00000060427.4
Ier2
immediate early response 2
chr10_+_58394361 1.205 ENSMUST00000020077.4
Lims1
LIM and senescent cell antigen-like domains 1
chr14_+_47298260 1.149 ENSMUST00000166743.1
Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
chr3_+_88716838 1.144 ENSMUST00000029692.8
ENSMUST00000171645.1
Rit1

Ras-like without CAAX 1

chr7_+_39588931 1.132 ENSMUST00000178791.1
ENSMUST00000098511.3
Gm2058

predicted gene 2058

chr13_-_85127514 1.078 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr3_+_88716884 1.049 ENSMUST00000172252.1
Rit1
Ras-like without CAAX 1
chr1_+_178405881 1.008 ENSMUST00000027775.7
Efcab2
EF-hand calcium binding domain 2
chr3_-_19264959 0.996 ENSMUST00000121951.1
Pde7a
phosphodiesterase 7A
chr2_-_177267036 0.955 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr3_-_116712644 0.891 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr7_-_99980431 0.870 ENSMUST00000080817.4
Rnf169
ring finger protein 169
chr10_-_76110956 0.817 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr5_+_48372363 0.776 ENSMUST00000030968.2
Pacrgl
PARK2 co-regulated-like
chr2_+_110597298 0.739 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr10_+_23797052 0.728 ENSMUST00000133289.1
Slc18b1
solute carrier family 18, subfamily B, member 1
chr3_-_19265007 0.719 ENSMUST00000091314.4
Pde7a
phosphodiesterase 7A
chr9_-_55512156 0.691 ENSMUST00000034866.8
Etfa
electron transferring flavoprotein, alpha polypeptide
chr9_+_54538984 0.672 ENSMUST00000060242.5
ENSMUST00000118413.1
Sh2d7

SH2 domain containing 7

chr12_-_90969768 0.668 ENSMUST00000181184.1
4930544I03Rik
RIKEN cDNA 4930544I03 gene
chr10_+_75037291 0.653 ENSMUST00000139384.1
Rab36
RAB36, member RAS oncogene family
chr2_-_73580288 0.646 ENSMUST00000028515.3
Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr5_-_73191848 0.607 ENSMUST00000176910.1
Fryl
furry homolog-like (Drosophila)
chr14_+_55560010 0.506 ENSMUST00000147981.1
ENSMUST00000133256.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr10_-_127030813 0.469 ENSMUST00000040560.4
Tsfm
Ts translation elongation factor, mitochondrial
chr19_-_33761949 0.450 ENSMUST00000025694.6
ENSMUST00000147153.1
Lipo1
Lipo2
lipase, member O1
lipase, member O2
chr7_-_45062393 0.443 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr10_-_127030789 0.419 ENSMUST00000120547.1
ENSMUST00000152054.1
Tsfm

Ts translation elongation factor, mitochondrial

chr3_+_10088173 0.414 ENSMUST00000061419.7
Gm9833
predicted gene 9833
chr2_-_163472561 0.390 ENSMUST00000109418.1
Fitm2
fat storage-inducing transmembrane protein 2
chr8_+_34054622 0.378 ENSMUST00000149618.1
Gm9951
predicted gene 9951
chr17_-_56036546 0.359 ENSMUST00000003268.9
Sh3gl1
SH3-domain GRB2-like 1
chr14_+_55559993 0.328 ENSMUST00000117236.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr17_-_32822200 0.305 ENSMUST00000179695.1
Zfp799
zinc finger protein 799
chrX_-_74393003 0.293 ENSMUST00000015427.6
Fam3a
family with sequence similarity 3, member A
chr7_+_126976338 0.292 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr7_-_80405425 0.287 ENSMUST00000107362.3
ENSMUST00000135306.1
Furin

furin (paired basic amino acid cleaving enzyme)

chr6_+_134640940 0.270 ENSMUST00000062755.8
Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr2_-_66410064 0.261 ENSMUST00000112366.1
Scn1a
sodium channel, voltage-gated, type I, alpha
chr11_+_117809687 0.230 ENSMUST00000120928.1
ENSMUST00000175737.1
Syngr2

synaptogyrin 2

chr11_+_117809653 0.230 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
Syngr2

Gm20708
synaptogyrin 2

predicted gene 20708
chr1_-_127840290 0.228 ENSMUST00000061512.2
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr2_+_152669461 0.203 ENSMUST00000125366.1
ENSMUST00000109825.1
ENSMUST00000089059.2
ENSMUST00000079247.3
H13



histocompatibility 13



chrX_-_160138375 0.192 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr1_+_178798438 0.181 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr9_+_72806874 0.167 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr14_+_58893465 0.159 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr3_-_95871367 0.148 ENSMUST00000142437.1
ENSMUST00000067298.4
Mrps21

mitochondrial ribosomal protein S21

chrM_+_7759 0.108 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr18_+_60774675 0.082 ENSMUST00000118551.1
Rps14
ribosomal protein S14
chr7_+_140763739 0.070 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr5_-_121527186 0.068 ENSMUST00000152270.1
Mapkapk5
MAP kinase-activated protein kinase 5
chr19_+_24875679 0.031 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr5_-_38491948 0.023 ENSMUST00000129099.1
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr17_-_26099257 0.008 ENSMUST00000053575.3
Gm8186
predicted gene 8186
chr2_+_152687137 0.008 ENSMUST00000062148.6
Mcts2
malignant T cell amplified sequence 2
chr15_+_81744848 0.006 ENSMUST00000109554.1
Zc3h7b
zinc finger CCCH type containing 7B
chr9_-_15301555 0.006 ENSMUST00000034414.8
4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr8_+_33599608 0.001 ENSMUST00000009774.9
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.4 GO:0035262 gonad morphogenesis(GO:0035262)
0.8 2.3 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.6 2.5 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.6 8.2 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.5 2.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.4 1.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.4 2.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.3 2.8 GO:0072615 interleukin-17 secretion(GO:0072615)
0.3 1.7 GO:0009235 cobalamin metabolic process(GO:0009235)
0.2 1.2 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.2 0.9 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.2 0.9 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 0.8 GO:1904659 glucose transmembrane transport(GO:1904659)
0.1 0.6 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.3 GO:1905034 regulation of antifungal innate immune response(GO:1905034) negative regulation of antifungal innate immune response(GO:1905035)
0.1 0.4 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.3 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.3 GO:0090472 dibasic protein processing(GO:0090472)
0.1 0.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.9 GO:2000780 negative regulation of double-strand break repair(GO:2000780)
0.0 0.7 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 2.5 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 4.0 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.4 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 1.8 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 2.0 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 1.3 GO:0060349 bone morphogenesis(GO:0060349)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.6 2.3 GO:0060187 cell pole(GO:0060187)
0.3 8.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 0.7 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.2 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.9 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 2.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.1 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.8 GO:0043296 apical junction complex(GO:0043296)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.7 3.6 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.7 2.8 GO:0008142 oxysterol binding(GO:0008142)
0.5 2.5 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.4 1.8 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.3 1.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 2.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.7 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 4.0 GO:0070888 E-box binding(GO:0070888)
0.1 1.7 GO:0005402 cation:sugar symporter activity(GO:0005402)
0.1 8.2 GO:0003774 motor activity(GO:0003774)
0.1 1.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 1.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.9 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.3 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 2.1 GO:0002039 p53 binding(GO:0002039)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.7 GO:0009055 electron carrier activity(GO:0009055)
0.0 1.4 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.8 GO:0051015 actin filament binding(GO:0051015)
0.0 2.1 GO:0000287 magnesium ion binding(GO:0000287)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.7 PID_ARF6_PATHWAY Arf6 signaling events
0.1 2.1 PID_BARD1_PATHWAY BARD1 signaling events
0.0 2.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.6 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.8 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 2.2 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 1.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 2.1 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.7 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex