Motif ID: Hoxd9

Z-value: 0.448


Transcription factors associated with Hoxd9:

Gene SymbolEntrez IDGene Name
Hoxd9 ENSMUSG00000043342.8 Hoxd9



Activity profile for motif Hoxd9.

activity profile for motif Hoxd9


Sorted Z-values histogram for motif Hoxd9

Sorted Z-values for motif Hoxd9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd9

PNG image of the network

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Top targets:


Showing 1 to 20 of 101 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_36811361 2.158 ENSMUST00000101534.1
Ptn
pleiotrophin
chr7_+_66365905 1.979 ENSMUST00000107486.1
Gm10974
predicted gene 10974
chr8_+_84723003 1.790 ENSMUST00000098571.4
G430095P16Rik
RIKEN cDNA G430095P16 gene
chrX_+_82948861 1.789 ENSMUST00000114000.1
Dmd
dystrophin, muscular dystrophy
chr3_-_116129615 1.566 ENSMUST00000029574.8
Vcam1
vascular cell adhesion molecule 1
chr5_-_77408034 1.363 ENSMUST00000163898.1
ENSMUST00000046746.6
Igfbp7

insulin-like growth factor binding protein 7

chr7_-_103827922 1.167 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs

hemoglobin, beta adult s chain

chr3_-_49757257 1.140 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr3_+_114030532 1.123 ENSMUST00000123619.1
ENSMUST00000092155.5
Col11a1

collagen, type XI, alpha 1

chr2_-_63184253 1.119 ENSMUST00000075052.3
ENSMUST00000112454.1
Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr13_-_105271039 1.012 ENSMUST00000069686.6
Rnf180
ring finger protein 180
chr17_-_78684262 0.986 ENSMUST00000145480.1
Strn
striatin, calmodulin binding protein
chr3_+_35754121 0.982 ENSMUST00000108186.1
ENSMUST00000029257.8
Atp11b

ATPase, class VI, type 11B

chr15_-_65014904 0.966 ENSMUST00000110100.2
Gm21961
predicted gene, 21961
chr8_+_66386292 0.951 ENSMUST00000039540.5
ENSMUST00000110253.2
March1

membrane-associated ring finger (C3HC4) 1

chr13_-_74376566 0.932 ENSMUST00000091481.2
Zfp72
zinc finger protein 72
chrX_+_85048309 0.848 ENSMUST00000113991.1
ENSMUST00000113992.2
Dmd

dystrophin, muscular dystrophy

chr5_-_62766153 0.822 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_136143497 0.800 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr2_-_116064721 0.779 ENSMUST00000110906.2
Meis2
Meis homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.7 2.2 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 1.9 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.1 1.6 GO:0061032 visceral serous pericardium development(GO:0061032)
0.0 1.4 GO:0050810 regulation of steroid biosynthetic process(GO:0050810)
0.2 1.1 GO:0035989 tendon development(GO:0035989)
0.0 1.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.0 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.1 1.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 0.9 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0 0.8 GO:0030903 notochord development(GO:0030903)
0.0 0.8 GO:0008542 visual learning(GO:0008542)
0.2 0.7 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.2 0.7 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.7 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.0 0.7 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.7 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 0.6 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.6 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.1 0.6 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 2.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.6 GO:0002102 podosome(GO:0002102)
0.1 1.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 1.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.4 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.3 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.2 GO:0016327 apicolateral plasma membrane(GO:0016327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:0002162 dystroglycan binding(GO:0002162)
0.7 2.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 1.9 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.4 1.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 1.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 1.2 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.0 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.8 GO:0005504 fatty acid binding(GO:0005504)
0.2 0.7 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.1 0.7 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 0.7 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 0.7 GO:0098821 BMP receptor activity(GO:0098821)
0.1 0.7 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 0.6 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 1.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.2 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.9 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID_BMP_PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.6 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.7 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.7 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.6 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.4 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.4 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling