Motif ID: Hsf1

Z-value: 0.503


Transcription factors associated with Hsf1:

Gene SymbolEntrez IDGene Name
Hsf1 ENSMUSG00000022556.9 Hsf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf1mm10_v2_chr15_+_76477404_76477461-0.344.1e-02Click!


Activity profile for motif Hsf1.

activity profile for motif Hsf1


Sorted Z-values histogram for motif Hsf1

Sorted Z-values for motif Hsf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_48555846 2.360 ENSMUST00000110345.1
ENSMUST00000110343.1
Tenm3

teneurin transmembrane protein 3

chr4_-_136892867 1.903 ENSMUST00000046332.5
C1qc
complement component 1, q subcomponent, C chain
chr4_+_152178126 1.636 ENSMUST00000075363.3
Acot7
acyl-CoA thioesterase 7
chr10_-_80844025 1.526 ENSMUST00000053986.7
Lingo3
leucine rich repeat and Ig domain containing 3
chr7_-_110862944 1.350 ENSMUST00000033050.3
Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr5_+_30281377 1.314 ENSMUST00000101448.3
Drc1
dynein regulatory complex subunit 1
chr8_+_36489191 1.207 ENSMUST00000171777.1
6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr6_-_136941887 1.092 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr7_+_49759100 1.048 ENSMUST00000085272.5
Htatip2
HIV-1 tat interactive protein 2, homolog (human)
chr4_+_42949814 1.022 ENSMUST00000037872.3
ENSMUST00000098112.2
Dnajb5

DnaJ (Hsp40) homolog, subfamily B, member 5

chr1_+_66321708 0.991 ENSMUST00000114013.1
Map2
microtubule-associated protein 2
chr5_+_66676098 0.982 ENSMUST00000031131.9
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr9_+_22411515 0.909 ENSMUST00000058868.7
9530077C05Rik
RIKEN cDNA 9530077C05 gene
chr7_-_89941084 0.796 ENSMUST00000075010.4
ENSMUST00000153470.1
l7Rn6

lethal, Chr 7, Rinchik 6

chr7_-_122067263 0.761 ENSMUST00000033159.3
Ears2
glutamyl-tRNA synthetase 2 (mitochondrial)(putative)
chr5_+_129787390 0.727 ENSMUST00000031402.8
Cct6a
chaperonin containing Tcp1, subunit 6a (zeta)
chr1_+_57774600 0.727 ENSMUST00000167971.1
ENSMUST00000170139.1
ENSMUST00000171699.1
ENSMUST00000164302.1
Spats2l



spermatogenesis associated, serine-rich 2-like



chr7_+_122067164 0.716 ENSMUST00000033158.4
Ubfd1
ubiquitin family domain containing 1
chr7_-_89941196 0.648 ENSMUST00000117354.1
l7Rn6
lethal, Chr 7, Rinchik 6
chr12_-_72236692 0.579 ENSMUST00000021497.9
ENSMUST00000137990.1
Rtn1

reticulon 1

chr3_+_79591356 0.574 ENSMUST00000029382.7
Ppid
peptidylprolyl isomerase D (cyclophilin D)
chr12_-_110696289 0.570 ENSMUST00000021698.6
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr11_+_83662579 0.555 ENSMUST00000019074.3
Ccl4
chemokine (C-C motif) ligand 4
chr12_-_110696248 0.525 ENSMUST00000124156.1
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr15_-_81400043 0.520 ENSMUST00000172107.1
ENSMUST00000169204.1
ENSMUST00000163382.1
St13


suppression of tumorigenicity 13


chr12_-_79172609 0.520 ENSMUST00000055262.6
Vti1b
vesicle transport through interaction with t-SNAREs 1B
chr1_+_57774842 0.515 ENSMUST00000167085.1
Spats2l
spermatogenesis associated, serine-rich 2-like
chr15_-_81399594 0.510 ENSMUST00000023039.8
St13
suppression of tumorigenicity 13
chr12_-_110696332 0.497 ENSMUST00000094361.4
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr16_+_23107413 0.466 ENSMUST00000023599.6
ENSMUST00000168891.1
Eif4a2

eukaryotic translation initiation factor 4A2

chr12_-_110695860 0.465 ENSMUST00000149189.1
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr12_+_88083697 0.463 ENSMUST00000177720.1
Gm16368
predicted pseudogene 16368
chr11_+_22990519 0.460 ENSMUST00000173867.1
ENSMUST00000020562.4
Cct4

chaperonin containing Tcp1, subunit 4 (delta)

chr19_-_7039987 0.445 ENSMUST00000025918.7
Stip1
stress-induced phosphoprotein 1
chr17_-_50094277 0.432 ENSMUST00000113195.1
Rftn1
raftlin lipid raft linker 1
chr4_-_133545906 0.425 ENSMUST00000030665.6
Nudc
nuclear distribution gene C homolog (Aspergillus)
chr1_+_66322102 0.414 ENSMUST00000123647.1
Map2
microtubule-associated protein 2
chr18_-_36766198 0.412 ENSMUST00000061522.7
Dnd1
dead end homolog 1 (zebrafish)
chr5_-_139484475 0.405 ENSMUST00000110851.1
ENSMUST00000079996.6
Zfand2a

zinc finger, AN1-type domain 2A

chr1_+_55088132 0.405 ENSMUST00000075242.6
Hspe1
heat shock protein 1 (chaperonin 10)
chr1_-_55088024 0.401 ENSMUST00000027123.8
Hspd1
heat shock protein 1 (chaperonin)
chr16_-_87495704 0.400 ENSMUST00000176750.1
ENSMUST00000175977.1
Cct8

chaperonin containing Tcp1, subunit 8 (theta)

chr5_-_139484420 0.400 ENSMUST00000150992.1
Zfand2a
zinc finger, AN1-type domain 2A
chr16_-_87495823 0.384 ENSMUST00000176041.1
ENSMUST00000026704.7
Cct8

chaperonin containing Tcp1, subunit 8 (theta)

chr15_+_81400132 0.368 ENSMUST00000163754.1
ENSMUST00000041609.4
Xpnpep3

X-prolyl aminopeptidase (aminopeptidase P) 3, putative

chr8_-_45382198 0.362 ENSMUST00000093526.6
Fam149a
family with sequence similarity 149, member A
chr15_-_31601786 0.355 ENSMUST00000022842.8
Cct5
chaperonin containing Tcp1, subunit 5 (epsilon)
chr15_-_31601506 0.355 ENSMUST00000161266.1
Cct5
chaperonin containing Tcp1, subunit 5 (epsilon)
chr10_-_61383523 0.339 ENSMUST00000020289.8
Pald1
phosphatase domain containing, paladin 1
chr1_-_55088156 0.327 ENSMUST00000127861.1
ENSMUST00000144077.1
Hspd1

heat shock protein 1 (chaperonin)

chr2_-_92460449 0.326 ENSMUST00000125276.1
Slc35c1
solute carrier family 35, member C1
chr16_+_23107754 0.322 ENSMUST00000077605.5
ENSMUST00000115341.3
Eif4a2

eukaryotic translation initiation factor 4A2

chr4_+_40722912 0.309 ENSMUST00000164233.1
ENSMUST00000137246.1
ENSMUST00000125442.1
Dnaja1


DnaJ (Hsp40) homolog, subfamily A, member 1


chrX_-_73660047 0.307 ENSMUST00000114472.1
Pnck
pregnancy upregulated non-ubiquitously expressed CaM kinase
chr7_-_70366735 0.300 ENSMUST00000089565.5
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr11_-_116843449 0.291 ENSMUST00000047616.3
Jmjd6
jumonji domain containing 6
chr15_+_87625214 0.287 ENSMUST00000068088.6
Fam19a5
family with sequence similarity 19, member A5
chr7_-_19310035 0.274 ENSMUST00000003640.2
Fosb
FBJ osteosarcoma oncogene B
chrX_-_73659724 0.263 ENSMUST00000114473.1
ENSMUST00000002087.7
Pnck

pregnancy upregulated non-ubiquitously expressed CaM kinase

chr5_+_149184678 0.263 ENSMUST00000139474.1
ENSMUST00000117878.1
Uspl1

ubiquitin specific peptidase like 1

chr7_+_111028951 0.261 ENSMUST00000005749.5
Ctr9
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr4_-_40722307 0.255 ENSMUST00000181475.1
Gm6297
predicted gene 6297
chr6_+_29853746 0.245 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
Ahcyl2



S-adenosylhomocysteine hydrolase-like 2



chr17_+_31564749 0.225 ENSMUST00000175806.1
ENSMUST00000097352.3
Pknox1

Pbx/knotted 1 homeobox

chr5_+_29735940 0.218 ENSMUST00000114839.1
Dnajb6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr4_+_40722461 0.217 ENSMUST00000030118.3
Dnaja1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr5_+_149184555 0.209 ENSMUST00000050472.9
Uspl1
ubiquitin specific peptidase like 1
chr12_-_54695829 0.208 ENSMUST00000162106.1
ENSMUST00000160085.1
ENSMUST00000161592.1
ENSMUST00000163433.1
Eapp



E2F-associated phosphoprotein



chr17_-_15041457 0.208 ENSMUST00000097398.4
ENSMUST00000040746.6
ENSMUST00000097400.4
Tcte3

Gm3448
t-complex-associated testis expressed 3

predicted gene 3448
chr5_+_149184648 0.207 ENSMUST00000122160.1
ENSMUST00000100410.3
ENSMUST00000119685.1
Uspl1


ubiquitin specific peptidase like 1


chr5_+_135887905 0.207 ENSMUST00000005077.6
Hspb1
heat shock protein 1
chr11_-_106579111 0.201 ENSMUST00000103070.2
Tex2
testis expressed gene 2
chr5_-_92675253 0.200 ENSMUST00000151180.1
ENSMUST00000150359.1
Ccdc158

coiled-coil domain containing 158

chr8_+_27023793 0.200 ENSMUST00000033873.7
Erlin2
ER lipid raft associated 2
chr5_-_149636331 0.199 ENSMUST00000074846.7
ENSMUST00000110498.1
ENSMUST00000127977.1
ENSMUST00000132412.1
Hsph1



heat shock 105kDa/110kDa protein 1



chr17_-_45572495 0.190 ENSMUST00000130406.1
Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chr10_+_86302854 0.182 ENSMUST00000132307.1
Timp3
tissue inhibitor of metalloproteinase 3
chr16_-_22265950 0.178 ENSMUST00000161286.1
Tra2b
transformer 2 beta homolog (Drosophila)
chr10_-_86705485 0.177 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr1_-_172206684 0.168 ENSMUST00000155109.1
Pea15a
phosphoprotein enriched in astrocytes 15A
chrX_-_150657366 0.167 ENSMUST00000148604.1
Tro
trophinin
chr5_-_36695969 0.164 ENSMUST00000031091.9
ENSMUST00000140063.1
D5Ertd579e

DNA segment, Chr 5, ERATO Doi 579, expressed

chrX_-_150657392 0.159 ENSMUST00000151403.2
ENSMUST00000087253.4
ENSMUST00000112709.1
ENSMUST00000163969.1
ENSMUST00000087258.3
Tro




trophinin




chr11_+_6560183 0.156 ENSMUST00000109722.2
Ccm2
cerebral cavernous malformation 2
chr12_-_54695813 0.143 ENSMUST00000110713.3
Eapp
E2F-associated phosphoprotein
chr9_+_18292267 0.138 ENSMUST00000001825.7
Chordc1
cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
chr7_+_119895836 0.130 ENSMUST00000106518.1
ENSMUST00000054440.3
Lyrm1

LYR motif containing 1

chr15_+_31602106 0.129 ENSMUST00000042702.6
Fam173b
family with sequence similarity 173, member B
chr12_-_54695885 0.113 ENSMUST00000067272.8
Eapp
E2F-associated phosphoprotein
chr2_+_72297895 0.108 ENSMUST00000144111.1
Zak
sterile alpha motif and leucine zipper containing kinase AZK
chr2_+_120463566 0.082 ENSMUST00000028749.7
ENSMUST00000110721.1
Capn3

calpain 3

chr11_-_5542177 0.082 ENSMUST00000020776.4
Ccdc117
coiled-coil domain containing 117
chr5_-_149636164 0.071 ENSMUST00000076410.4
Hsph1
heat shock 105kDa/110kDa protein 1
chr17_+_47593516 0.068 ENSMUST00000182874.1
Ccnd3
cyclin D3
chr4_+_155601414 0.066 ENSMUST00000105608.2
Slc35e2
solute carrier family 35, member E2
chr17_-_47010513 0.058 ENSMUST00000113337.2
ENSMUST00000113335.2
Ubr2

ubiquitin protein ligase E3 component n-recognin 2

chr11_-_116335384 0.054 ENSMUST00000036215.7
Foxj1
forkhead box J1
chr14_-_48667508 0.038 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
Otx2



orthodenticle homolog 2 (Drosophila)



chr6_+_58831748 0.036 ENSMUST00000126292.1
ENSMUST00000031823.5
Herc3

hect domain and RLD 3

chr6_-_72439549 0.035 ENSMUST00000059472.8
Mat2a
methionine adenosyltransferase II, alpha
chrX_-_140956675 0.035 ENSMUST00000033805.8
ENSMUST00000112978.1
Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr4_+_155601854 0.033 ENSMUST00000118607.1
Slc35e2
solute carrier family 35, member E2
chr5_+_29735991 0.030 ENSMUST00000012734.5
Dnajb6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr10_+_59323296 0.026 ENSMUST00000009789.8
ENSMUST00000092512.4
ENSMUST00000105466.2
P4ha1


procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide


chr5_+_129020069 0.022 ENSMUST00000031383.7
ENSMUST00000111343.1
Ran

RAN, member RAS oncogene family

chr2_+_157560078 0.016 ENSMUST00000153739.2
ENSMUST00000173595.1
ENSMUST00000109526.1
ENSMUST00000173839.1
ENSMUST00000173041.1
ENSMUST00000173793.1
ENSMUST00000172487.1
ENSMUST00000088484.5
Nnat







neuronatin







chr17_-_56874421 0.015 ENSMUST00000043062.4
Acsbg2
acyl-CoA synthetase bubblegum family member 2
chr11_+_100619217 0.013 ENSMUST00000107376.1
Nkiras2
NFKB inhibitor interacting Ras-like protein 2
chr17_+_47593444 0.002 ENSMUST00000182209.1
Ccnd3
cyclin D3
chr12_+_117843873 0.001 ENSMUST00000176735.1
ENSMUST00000177339.1
Cdca7l

cell division cycle associated 7 like

chr6_-_51469869 0.000 ENSMUST00000114459.1
ENSMUST00000069949.6
Hnrnpa2b1

heterogeneous nuclear ribonucleoprotein A2/B1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.3 1.0 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.3 2.1 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.3 2.4 GO:0097264 self proteolysis(GO:0097264)
0.3 1.9 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.2 1.0 GO:0007412 axon target recognition(GO:0007412)
0.2 2.7 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.2 0.7 GO:0002842 positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041)
0.2 0.6 GO:0071492 cellular response to UV-A(GO:0071492)
0.2 0.6 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.2 1.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 0.7 GO:0030576 Cajal body organization(GO:0030576)
0.1 1.3 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.1 1.0 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.1 1.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.8 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 0.3 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.1 0.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.3 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135)
0.1 1.3 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 0.2 GO:0019062 virion attachment to host cell(GO:0019062) transforming growth factor beta activation(GO:0036363) adhesion of symbiont to host cell(GO:0044650) complement-dependent cytotoxicity(GO:0097278)
0.1 0.3 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 0.5 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 0.8 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.1 0.2 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.0 0.3 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.0 0.2 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 0.5 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.5 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 1.4 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.4 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.2 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.4 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.1 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 0.4 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.2 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.1 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0 0.4 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.2 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.2 GO:0021796 cerebral cortex regionalization(GO:0021796) embryonic brain development(GO:1990403)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.2 2.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 1.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 1.9 GO:0005581 collagen trimer(GO:0005581)
0.0 0.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 1.0 GO:0000502 proteasome complex(GO:0000502)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0002135 CTP binding(GO:0002135)
0.3 1.0 GO:0032564 dATP binding(GO:0032564)
0.2 1.0 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.2 0.7 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.2 1.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 0.7 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.2 1.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 1.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 1.6 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.7 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 0.6 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 2.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 1.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.5 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.6 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 0.3 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 0.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.3 GO:0001972 retinoic acid binding(GO:0001972)
0.0 1.0 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0031432 titin binding(GO:0031432)
0.0 1.9 GO:0051087 chaperone binding(GO:0051087)
0.0 0.8 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.0 GO:0070883 pre-miRNA binding(GO:0070883)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.4 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.7 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 2.1 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.8 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.6 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import