Motif ID: Hsf1

Z-value: 0.503


Transcription factors associated with Hsf1:

Gene SymbolEntrez IDGene Name
Hsf1 ENSMUSG00000022556.9 Hsf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf1mm10_v2_chr15_+_76477404_76477461-0.344.1e-02Click!


Activity profile for motif Hsf1.

activity profile for motif Hsf1


Sorted Z-values histogram for motif Hsf1

Sorted Z-values for motif Hsf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_48555846 2.360 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr4_-_136892867 1.903 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr4_+_152178126 1.636 ENSMUST00000075363.3
 Acot7
acyl-CoA thioesterase 7
chr10_-_80844025 1.526 ENSMUST00000053986.7
 Lingo3
leucine rich repeat and Ig domain containing 3
chr7_-_110862944 1.350 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr5_+_30281377 1.314 ENSMUST00000101448.3
 Drc1
dynein regulatory complex subunit 1
chr8_+_36489191 1.207 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr6_-_136941887 1.092 ENSMUST00000111891.1
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr7_+_49759100 1.048 ENSMUST00000085272.5
 Htatip2
HIV-1 tat interactive protein 2, homolog (human)
chr4_+_42949814 1.022 ENSMUST00000037872.3
ENSMUST00000098112.2
 Dnajb5

DnaJ (Hsp40) homolog, subfamily B, member 5

chr1_+_66321708 0.991 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr5_+_66676098 0.982 ENSMUST00000031131.9
 Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr9_+_22411515 0.909 ENSMUST00000058868.7
 9530077C05Rik
RIKEN cDNA 9530077C05 gene
chr7_-_89941084 0.796 ENSMUST00000075010.4
ENSMUST00000153470.1
 l7Rn6

lethal, Chr 7, Rinchik 6

chr7_-_122067263 0.761 ENSMUST00000033159.3
 Ears2
glutamyl-tRNA synthetase 2 (mitochondrial)(putative)
chr5_+_129787390 0.727 ENSMUST00000031402.8
 Cct6a
chaperonin containing Tcp1, subunit 6a (zeta)
chr1_+_57774600 0.727 ENSMUST00000167971.1
ENSMUST00000170139.1
ENSMUST00000171699.1
ENSMUST00000164302.1
 Spats2l



spermatogenesis associated, serine-rich 2-like



chr7_+_122067164 0.716 ENSMUST00000033158.4
 Ubfd1
ubiquitin family domain containing 1
chr7_-_89941196 0.648 ENSMUST00000117354.1
 l7Rn6
lethal, Chr 7, Rinchik 6
chr12_-_72236692 0.579 ENSMUST00000021497.9
ENSMUST00000137990.1
 Rtn1

reticulon 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.3 2.4 GO:0097264 self proteolysis(GO:0097264)
0.3 2.1 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.3 1.9 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.4 1.6 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 1.4 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 1.3 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.1 1.3 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 1.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.2 1.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.3 1.0 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.2 1.0 GO:0007412 axon target recognition(GO:0007412)
0.1 1.0 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.1 0.8 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 0.8 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 0.7 GO:0002842 positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041)
0.2 0.7 GO:0030576 Cajal body organization(GO:0030576)
0.2 0.6 GO:0071492 cellular response to UV-A(GO:0071492)
0.2 0.6 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.4 2.1 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.0 1.9 GO:0005581 collagen trimer(GO:0005581)
0.2 1.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 1.0 GO:0000502 proteasome complex(GO:0000502)
0.0 0.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.4 2.2 GO:0002135 CTP binding(GO:0002135)
0.0 1.9 GO:0051087 chaperone binding(GO:0051087)
0.1 1.6 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 1.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 1.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 1.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.3 1.0 GO:0032564 dATP binding(GO:0032564)
0.2 1.0 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 1.0 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.8 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 0.7 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.2 0.7 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 0.7 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 0.6 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.6 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.5 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 2.1 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.3 1.9 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.8 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR