Motif ID: Hsf2

Z-value: 1.171


Transcription factors associated with Hsf2:

Gene SymbolEntrez IDGene Name
Hsf2 ENSMUSG00000019878.7 Hsf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf2mm10_v2_chr10_+_57486354_574864140.764.0e-08Click!


Activity profile for motif Hsf2.

activity profile for motif Hsf2


Sorted Z-values histogram for motif Hsf2

Sorted Z-values for motif Hsf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_92164666 7.095 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr1_-_138847579 5.661 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr7_-_4752972 4.643 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr8_-_110168204 4.540 ENSMUST00000003754.6
 Calb2
calbindin 2
chr1_+_138963709 4.538 ENSMUST00000168527.1
 Dennd1b
DENN/MADD domain containing 1B
chr13_+_51645232 4.473 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr1_+_136467958 4.209 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr4_-_53159885 4.179 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr4_+_128883549 4.174 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chr10_-_92165159 4.048 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr17_-_70849644 4.000 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr15_+_57694651 3.739 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr3_+_94342092 3.607 ENSMUST00000029794.5
 Them5
thioesterase superfamily member 5
chr17_-_70851189 3.602 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr11_-_11970540 3.543 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr17_-_25797032 3.369 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr14_-_65833963 3.360 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr16_-_45844228 3.344 ENSMUST00000076333.5
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr11_-_100939357 3.320 ENSMUST00000092671.5
ENSMUST00000103114.1
 Stat3

signal transducer and activator of transcription 3

chr2_+_152847961 3.306 ENSMUST00000164120.1
ENSMUST00000178997.1
ENSMUST00000109816.1
 Tpx2


TPX2, microtubule-associated protein homolog (Xenopus laevis)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 209 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.0 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.6 8.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.9 6.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
1.0 6.2 GO:0003350 pulmonary myocardium development(GO:0003350)
1.5 5.8 GO:0021698 cerebellar cortex structural organization(GO:0021698)
1.1 5.7 GO:0035262 gonad morphogenesis(GO:0035262)
1.1 5.4 GO:0003213 cardiac right atrium morphogenesis(GO:0003213)
1.8 5.3 GO:0030421 defecation(GO:0030421)
0.2 4.8 GO:0046596 regulation of viral entry into host cell(GO:0046596)
0.7 4.6 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
1.0 4.2 GO:0055099 response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
0.3 3.9 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.4 3.8 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.4 3.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.7 3.4 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 3.4 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.8 3.3 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.1 3.2 GO:0032611 interleukin-1 beta production(GO:0032611)
0.2 3.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 3.1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 GO:0016459 myosin complex(GO:0016459)
0.4 6.6 GO:0045180 basal cortex(GO:0045180)
0.8 6.4 GO:0005818 aster(GO:0005818)
0.0 5.7 GO:0016607 nuclear speck(GO:0016607)
0.0 5.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 4.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 4.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 4.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 4.3 GO:0005921 gap junction(GO:0005921)
0.1 4.2 GO:0051233 spindle midzone(GO:0051233)
0.3 4.0 GO:0030061 mitochondrial crista(GO:0030061)
0.9 3.8 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.3 3.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 2.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.5 2.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 2.4 GO:0005802 trans-Golgi network(GO:0005802)
0.7 2.2 GO:0042585 germinal vesicle(GO:0042585)
0.0 2.1 GO:0005882 intermediate filament(GO:0005882)
0.0 2.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 2.0 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 171 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.9 GO:0070410 co-SMAD binding(GO:0070410)
0.1 6.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.7 6.4 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.5 6.2 GO:0038191 neuropilin binding(GO:0038191)
0.1 5.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.1 4.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
1.4 4.2 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 4.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 3.8 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.6 3.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 3.4 GO:0003774 motor activity(GO:0003774)
0.4 3.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 3.2 GO:0008201 heparin binding(GO:0008201)
0.0 3.0 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.0 2.9 GO:0005110 frizzled-2 binding(GO:0005110)
0.2 2.9 GO:0035497 cAMP response element binding(GO:0035497)
0.1 2.9 GO:0005112 Notch binding(GO:0005112)
0.0 2.7 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 2.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 2.6 GO:0032452 histone demethylase activity(GO:0032452)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 8.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 6.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 5.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 5.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 4.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 4.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.1 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.2 3.3 ST_STAT3_PATHWAY STAT3 Pathway
0.1 2.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.3 PID_ATM_PATHWAY ATM pathway
0.0 2.2 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.1 1.9 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.8 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 1.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.4 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.3 PID_REELIN_PATHWAY Reelin signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 6.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 5.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 4.2 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 3.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 3.7 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.2 3.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 3.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 2.6 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 2.5 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.2 2.2 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 2.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 1.9 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.9 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.8 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 1.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 1.4 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)