Motif ID: Hsf4

Z-value: 0.613


Transcription factors associated with Hsf4:

Gene SymbolEntrez IDGene Name
Hsf4 ENSMUSG00000033249.4 Hsf4



Activity profile for motif Hsf4.

activity profile for motif Hsf4


Sorted Z-values histogram for motif Hsf4

Sorted Z-values for motif Hsf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_71215779 2.382 ENSMUST00000034723.5
 Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
chr4_-_136892867 1.989 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr1_+_194938821 1.752 ENSMUST00000016638.2
ENSMUST00000110815.2
 Cd34

CD34 antigen

chr15_-_66801577 1.737 ENSMUST00000168589.1
 Sla
src-like adaptor
chr12_+_75308308 1.651 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr7_-_110862944 1.479 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr4_-_46566432 1.316 ENSMUST00000030021.7
ENSMUST00000107757.1
 Coro2a

coronin, actin binding protein 2A

chr10_-_80844025 1.315 ENSMUST00000053986.7
 Lingo3
leucine rich repeat and Ig domain containing 3
chr16_+_91225550 1.260 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr1_+_195017399 1.233 ENSMUST00000181273.1
 A330023F24Rik
RIKEN cDNA A330023F24 gene
chr8_-_71537402 1.127 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr10_-_62507737 1.088 ENSMUST00000020271.6
 Srgn
serglycin
chr12_-_110696289 0.939 ENSMUST00000021698.6
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr12_-_110696332 0.921 ENSMUST00000094361.4
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr15_+_82252397 0.812 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr11_-_59163281 0.741 ENSMUST00000069631.2
 Iba57
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr14_+_34375504 0.739 ENSMUST00000111908.1
 Mmrn2
multimerin 2
chr17_+_17831004 0.738 ENSMUST00000172097.2
 4930546H06Rik
RIKEN cDNA 4930546H06 gene
chr9_-_13827029 0.726 ENSMUST00000148086.1
ENSMUST00000034398.5
 Cep57

centrosomal protein 57

chr9_+_13827708 0.682 ENSMUST00000059579.5
 Fam76b
family with sequence similarity 76, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.9 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.8 2.4 GO:0035799 ureter maturation(GO:0035799)
0.3 2.0 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.6 1.8 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.1 1.7 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 1.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3 1.6 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 1.6 GO:0034453 microtubule anchoring(GO:0034453)
0.1 1.5 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.4 1.3 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.4 1.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.3 1.1 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.0 1.0 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.3 0.8 GO:0019043 establishment of viral latency(GO:0019043)
0.0 0.8 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 0.7 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.1 0.7 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 0.7 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.7 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0 0.7 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.9 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.0 2.3 GO:0005581 collagen trimer(GO:0005581)
0.2 2.0 GO:0046930 pore complex(GO:0046930)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.6 GO:0005604 basement membrane(GO:0005604)
0.0 1.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 1.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.1 GO:0042629 mast cell granule(GO:0042629)
0.2 1.0 GO:0097512 cardiac myofibril(GO:0097512)
0.2 0.7 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 0.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.7 GO:0000800 lateral element(GO:0000800)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.5 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.5 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.9 GO:0030911 TPR domain binding(GO:0030911)
0.5 2.4 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 2.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 1.8 GO:0043199 sulfate binding(GO:0043199)
0.2 1.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 1.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.4 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 1.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 0.7 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)
0.2 0.7 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 0.7 GO:0016018 cyclosporin A binding(GO:0016018)
0.2 0.6 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.6 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.6 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.9 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.2 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 0.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.2 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 2.9 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.3 2.0 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 1.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.8 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 0.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.5 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.5 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.4 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.1 0.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.4 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation