Motif ID: Hsfy2
Z-value: 1.231
Transcription factors associated with Hsfy2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hsfy2 | ENSMUSG00000045336.4 | Hsfy2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
| 1.2 | 4.7 | GO:2001045 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 1.1 | 5.6 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 1.1 | 7.4 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 1.0 | 1.0 | GO:0002331 | pre-B cell allelic exclusion(GO:0002331) |
| 0.7 | 21.7 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.6 | 6.2 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.6 | 3.4 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.5 | 6.1 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.5 | 6.1 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.5 | 1.5 | GO:0071649 | regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) |
| 0.5 | 3.4 | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
| 0.5 | 3.2 | GO:0070458 | detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458) |
| 0.4 | 1.3 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 0.4 | 1.2 | GO:0098501 | polynucleotide dephosphorylation(GO:0098501) |
| 0.4 | 2.0 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.4 | 1.1 | GO:0002586 | positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) |
| 0.4 | 1.1 | GO:1904884 | telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884) |
| 0.4 | 2.6 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.4 | 2.5 | GO:0008300 | isoprenoid catabolic process(GO:0008300) |
| 0.3 | 1.0 | GO:0023016 | signal transduction by trans-phosphorylation(GO:0023016) |
| 0.3 | 2.3 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) axis elongation involved in somitogenesis(GO:0090245) |
| 0.3 | 1.3 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 0.3 | 0.8 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.2 | 0.7 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.2 | 1.2 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
| 0.2 | 4.1 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.2 | 2.1 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
| 0.2 | 3.2 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.2 | 1.8 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.2 | 1.4 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.2 | 0.8 | GO:0033762 | response to glucagon(GO:0033762) |
| 0.2 | 2.5 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.2 | 3.6 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.2 | 0.9 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.2 | 1.3 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.2 | 0.6 | GO:0042726 | flavin-containing compound metabolic process(GO:0042726) |
| 0.2 | 8.6 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 0.7 | GO:0097211 | response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211) |
| 0.2 | 9.9 | GO:0035307 | positive regulation of protein dephosphorylation(GO:0035307) |
| 0.2 | 5.8 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.2 | 1.5 | GO:0060330 | regulation of response to interferon-gamma(GO:0060330) |
| 0.2 | 0.5 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.2 | 10.6 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.2 | 1.1 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.1 | 1.0 | GO:0019254 | carnitine metabolic process, CoA-linked(GO:0019254) |
| 0.1 | 0.4 | GO:0001180 | transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) |
| 0.1 | 6.8 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.1 | 1.1 | GO:0071907 | determination of digestive tract left/right asymmetry(GO:0071907) |
| 0.1 | 1.1 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
| 0.1 | 1.7 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.1 | 0.5 | GO:0060279 | positive regulation of ovulation(GO:0060279) |
| 0.1 | 0.4 | GO:1902605 | heterotrimeric G-protein complex assembly(GO:1902605) |
| 0.1 | 0.4 | GO:1904569 | regulation of selenocysteine incorporation(GO:1904569) |
| 0.1 | 0.7 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 0.1 | 1.0 | GO:0070874 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
| 0.1 | 1.1 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.1 | 0.5 | GO:1900169 | glucocorticoid mediated signaling pathway(GO:0043402) regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 0.1 | 1.2 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 0.4 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
| 0.1 | 0.4 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
| 0.1 | 2.1 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.1 | 6.0 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.1 | 1.2 | GO:0070933 | DNA double-strand break processing(GO:0000729) histone H4 deacetylation(GO:0070933) |
| 0.1 | 5.3 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.1 | 1.3 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.1 | 0.5 | GO:1903232 | melanosome assembly(GO:1903232) |
| 0.1 | 0.3 | GO:0039533 | regulation of MDA-5 signaling pathway(GO:0039533) |
| 0.1 | 1.4 | GO:0070508 | sterol import(GO:0035376) cholesterol import(GO:0070508) |
| 0.1 | 5.0 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.1 | 0.6 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
| 0.1 | 2.4 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.1 | 0.8 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 0.5 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 1.0 | GO:0018065 | protein-cofactor linkage(GO:0018065) |
| 0.1 | 1.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 0.3 | GO:0046077 | dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077) |
| 0.1 | 1.8 | GO:0035036 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) |
| 0.1 | 0.4 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.1 | 0.2 | GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
| 0.1 | 1.0 | GO:0046498 | S-adenosylhomocysteine metabolic process(GO:0046498) |
| 0.1 | 0.5 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.1 | 0.6 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.1 | 5.6 | GO:0010921 | regulation of phosphatase activity(GO:0010921) |
| 0.1 | 0.1 | GO:0048496 | maintenance of organ identity(GO:0048496) |
| 0.1 | 1.1 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.1 | 0.3 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.1 | 3.5 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.1 | 0.1 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 0.1 | 0.5 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.1 | 0.4 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.1 | 0.3 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
| 0.0 | 2.2 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.0 | 0.1 | GO:0006490 | oligosaccharide-lipid intermediate biosynthetic process(GO:0006490) |
| 0.0 | 1.6 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 0.5 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.0 | 1.4 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.0 | 0.3 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.0 | 0.5 | GO:0060766 | negative regulation of androgen receptor signaling pathway(GO:0060766) |
| 0.0 | 0.7 | GO:0035337 | fatty-acyl-CoA metabolic process(GO:0035337) |
| 0.0 | 0.3 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.0 | 0.6 | GO:0043045 | DNA methylation involved in embryo development(GO:0043045) DNA demethylation(GO:0080111) changes to DNA methylation involved in embryo development(GO:1901538) |
| 0.0 | 2.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.3 | GO:0048736 | appendage development(GO:0048736) limb development(GO:0060173) |
| 0.0 | 0.4 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 1.1 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.0 | 0.5 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.0 | 1.7 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.0 | 2.5 | GO:0007093 | mitotic cell cycle checkpoint(GO:0007093) |
| 0.0 | 0.6 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.0 | 1.6 | GO:0043297 | apical junction assembly(GO:0043297) |
| 0.0 | 0.4 | GO:0031953 | negative regulation of protein autophosphorylation(GO:0031953) |
| 0.0 | 0.4 | GO:0046036 | CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036) |
| 0.0 | 0.5 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.0 | 0.4 | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway(GO:0002755) |
| 0.0 | 0.1 | GO:0071475 | cellular hyperosmotic salinity response(GO:0071475) double-strand break repair via classical nonhomologous end joining(GO:0097680) |
| 0.0 | 0.1 | GO:0036228 | protein targeting to nuclear inner membrane(GO:0036228) |
| 0.0 | 2.3 | GO:0042476 | odontogenesis(GO:0042476) |
| 0.0 | 0.2 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.0 | 0.2 | GO:0009301 | snRNA transcription(GO:0009301) |
| 0.0 | 0.9 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 1.1 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.0 | 0.3 | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176) |
| 0.0 | 2.5 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.0 | 0.1 | GO:0044351 | macropinocytosis(GO:0044351) |
| 0.0 | 2.2 | GO:0000070 | mitotic sister chromatid segregation(GO:0000070) |
| 0.0 | 0.5 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 0.2 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.0 | 0.2 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
| 0.0 | 2.2 | GO:0050772 | positive regulation of axonogenesis(GO:0050772) |
| 0.0 | 0.0 | GO:2000373 | regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.0 | 0.1 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.0 | 0.3 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.0 | 0.0 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
| 0.0 | 0.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.2 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 0.1 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.0 | 1.7 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.0 | 0.7 | GO:0006879 | cellular iron ion homeostasis(GO:0006879) |
| 0.0 | 0.2 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
| 0.0 | 0.6 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.0 | 0.1 | GO:1900095 | regulation of dosage compensation by inactivation of X chromosome(GO:1900095) |
| 0.0 | 0.1 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 0.2 | GO:0042415 | norepinephrine metabolic process(GO:0042415) |
| 0.0 | 0.1 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.0 | 0.1 | GO:0036035 | osteoclast development(GO:0036035) |
| 0.0 | 0.3 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.1 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.0 | 3.7 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.0 | 0.6 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.0 | 0.3 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 25.6 | GO:0005818 | aster(GO:0005818) |
| 1.6 | 6.3 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 1.1 | 3.2 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.8 | 3.3 | GO:0008623 | CHRAC(GO:0008623) |
| 0.5 | 2.2 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.4 | 2.2 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.4 | 4.9 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.3 | 1.1 | GO:0061702 | inflammasome complex(GO:0061702) |
| 0.3 | 1.1 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.2 | 2.1 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.2 | 0.6 | GO:0000801 | central element(GO:0000801) |
| 0.2 | 1.1 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.2 | 0.5 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.2 | 1.4 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.1 | 1.6 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 3.7 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.1 | 0.4 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.1 | 1.6 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.1 | 1.8 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.1 | 5.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 0.7 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 0.6 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.1 | 6.1 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 0.6 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.1 | 0.8 | GO:0045275 | respiratory chain complex III(GO:0045275) |
| 0.1 | 2.5 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 0.5 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 1.3 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 0.3 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.1 | 0.3 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.1 | 2.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 3.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 2.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 0.5 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 0.5 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 1.1 | GO:0001741 | XY body(GO:0001741) |
| 0.0 | 0.1 | GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540) |
| 0.0 | 0.3 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 3.1 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 1.4 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 3.0 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 0.5 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 0.2 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.0 | 0.9 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 1.2 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.4 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.8 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 3.0 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.1 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
| 0.0 | 0.8 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 1.2 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.3 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 5.7 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 2.0 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 0.1 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.0 | 1.5 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.4 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.1 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.0 | 7.9 | GO:0005929 | cilium(GO:0005929) |
| 0.0 | 1.3 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.2 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
| 0.0 | 0.7 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.1 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 0.5 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.1 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 9.9 | GO:0005694 | chromosome(GO:0005694) |
| 0.0 | 0.4 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.0 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.0 | 1.4 | GO:0030027 | lamellipodium(GO:0030027) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 18.7 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 2.0 | 6.1 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 1.6 | 6.4 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 1.4 | 6.8 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 1.0 | 6.2 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.9 | 4.7 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.9 | 3.4 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.9 | 2.6 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.7 | 6.1 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.6 | 4.1 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.6 | 4.4 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.5 | 4.9 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.5 | 3.2 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.5 | 1.4 | GO:0032052 | bile acid binding(GO:0032052) |
| 0.4 | 1.3 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 0.4 | 2.0 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.4 | 5.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.4 | 1.8 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.3 | 1.5 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.3 | 1.0 | GO:0004092 | carnitine O-acetyltransferase activity(GO:0004092) |
| 0.2 | 1.7 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.2 | 1.2 | GO:0046403 | polynucleotide 3'-phosphatase activity(GO:0046403) |
| 0.2 | 1.4 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.2 | 2.5 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.2 | 0.6 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
| 0.2 | 3.8 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.2 | 1.1 | GO:0032405 | MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407) |
| 0.2 | 1.1 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.2 | 1.0 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.2 | 0.5 | GO:0035651 | AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651) |
| 0.2 | 1.6 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.1 | 0.4 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.1 | 1.1 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 0.5 | GO:0004103 | choline kinase activity(GO:0004103) |
| 0.1 | 1.7 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 2.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.0 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 3.2 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.1 | 0.6 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.1 | 0.4 | GO:0003883 | CTP synthase activity(GO:0003883) |
| 0.1 | 0.6 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.1 | 1.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 0.6 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.1 | 0.4 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.1 | 2.9 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 0.8 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.1 | 8.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 2.4 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.1 | 0.5 | GO:0089720 | caspase binding(GO:0089720) |
| 0.1 | 0.5 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.1 | 0.6 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 0.1 | 1.5 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 0.3 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.1 | 0.8 | GO:0035005 | lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.1 | 0.4 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.1 | 0.7 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.1 | 1.1 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.1 | 0.4 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.1 | 0.5 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.1 | 0.2 | GO:0036004 | GAF domain binding(GO:0036004) |
| 0.1 | 2.4 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.1 | 0.5 | GO:0016421 | CoA carboxylase activity(GO:0016421) |
| 0.1 | 2.3 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 0.5 | GO:0046790 | virion binding(GO:0046790) |
| 0.1 | 0.3 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.1 | 0.5 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 0.4 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 0.0 | 1.0 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 1.0 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 9.8 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.1 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 0.0 | 0.9 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.9 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.0 | 0.8 | GO:0016854 | racemase and epimerase activity(GO:0016854) |
| 0.0 | 0.8 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.8 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.4 | GO:0015299 | solute:proton antiporter activity(GO:0015299) |
| 0.0 | 0.9 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 1.3 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.0 | 6.3 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 2.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.2 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.0 | 0.1 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 0.0 | 0.1 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.0 | 0.4 | GO:0031418 | L-ascorbic acid binding(GO:0031418) |
| 0.0 | 0.7 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.0 | 0.3 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 0.0 | 1.1 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 0.4 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.1 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.0 | 0.3 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 0.3 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.3 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 1.8 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 0.8 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.0 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.0 | 0.3 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 0.1 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.0 | 1.8 | GO:0004386 | helicase activity(GO:0004386) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 18.7 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.3 | 2.6 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 4.9 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 7.3 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.2 | 5.6 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 0.5 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 2.7 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 1.7 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 2.0 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 3.4 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.3 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.4 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.1 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 1.6 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.7 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.1 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.8 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.4 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.4 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 0.8 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.8 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.2 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.9 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.5 | PID_LKB1_PATHWAY | LKB1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.7 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.2 | 2.3 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 1.1 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 1.1 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.2 | 1.1 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 1.2 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 3.2 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 2.7 | REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.1 | 1.4 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.1 | 0.5 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.1 | 2.3 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 1.2 | REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.0 | 0.4 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.0 | 0.9 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 4.7 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.0 | 0.9 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.7 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 0.9 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 1.6 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.8 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 1.1 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.0 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 1.3 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 1.5 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.7 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 1.4 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 0.4 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.6 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.5 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.8 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.2 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 0.6 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 1.4 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 0.4 | REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 2.1 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.0 | 0.3 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.4 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 2.8 | REACTOME_GENERIC_TRANSCRIPTION_PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 0.6 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.6 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.0 | 0.2 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.2 | REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 0.6 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.4 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
