Motif ID: Id4

Z-value: 0.761


Transcription factors associated with Id4:

Gene SymbolEntrez IDGene Name
Id4 ENSMUSG00000021379.1 Id4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Id4mm10_v2_chr13_+_48261427_48261427-0.289.1e-02Click!


Activity profile for motif Id4.

activity profile for motif Id4


Sorted Z-values histogram for motif Id4

Sorted Z-values for motif Id4



Network of associatons between targets according to the STRING database.



First level regulatory network of Id4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 6.609 ENSMUST00000164163.1
 Sla
src-like adaptor
chr11_-_67922136 6.299 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr3_-_82145865 4.133 ENSMUST00000048976.6
 Gucy1a3
guanylate cyclase 1, soluble, alpha 3
chr12_+_82616885 4.028 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr11_+_42419729 3.318 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr13_+_83504032 3.082 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr15_-_98677451 2.930 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
 Rnd1


Rho family GTPase 1


chr13_-_57907587 2.761 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr4_+_125490688 2.397 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr11_-_7213897 2.397 ENSMUST00000020702.4
ENSMUST00000135887.2
 Igfbp3

insulin-like growth factor binding protein 3

chr15_-_60824942 2.360 ENSMUST00000100635.3
 Fam84b
family with sequence similarity 84, member B
chr15_-_71727815 2.303 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr8_+_36457548 2.294 ENSMUST00000135373.1
ENSMUST00000147525.1
 6430573F11Rik

RIKEN cDNA 6430573F11 gene

chr14_-_121797670 2.250 ENSMUST00000100299.3
 Dock9
dedicator of cytokinesis 9
chr8_-_70439557 2.238 ENSMUST00000076615.5
 Crtc1
CREB regulated transcription coactivator 1
chr19_-_57314896 2.210 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr1_-_180483410 2.202 ENSMUST00000136521.1
ENSMUST00000179826.1
 6330403A02Rik

RIKEN cDNA 6330403A02 gene

chr7_+_123982799 2.200 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr10_+_123264076 2.183 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr8_+_70493156 2.148 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 305 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.6 GO:0034605 cellular response to heat(GO:0034605)
0.1 7.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 6.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 5.7 GO:0016579 protein deubiquitination(GO:0016579)
0.8 4.1 GO:0075136 response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
0.0 4.0 GO:1903749 positive regulation of establishment of protein localization to mitochondrion(GO:1903749)
0.5 3.6 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 3.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.4 3.3 GO:0071420 cellular response to histamine(GO:0071420)
0.1 3.3 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
1.1 3.2 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.6 3.1 GO:0042636 negative regulation of hair cycle(GO:0042636) negative regulation of hair follicle development(GO:0051799)
0.3 2.9 GO:0046959 habituation(GO:0046959)
0.1 2.9 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.1 2.7 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.6 2.4 GO:2000832 androgen secretion(GO:0035935) testosterone secretion(GO:0035936) positive regulation of apoptotic DNA fragmentation(GO:1902512) negative regulation of steroid hormone secretion(GO:2000832) regulation of androgen secretion(GO:2000834) regulation of testosterone secretion(GO:2000843)
0.2 2.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 2.4 GO:0008210 estrogen metabolic process(GO:0008210)
0.5 2.3 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.1 2.3 GO:0016322 neuron remodeling(GO:0016322)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 6.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 4.3 GO:0005802 trans-Golgi network(GO:0005802)
0.1 3.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 3.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 3.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 3.2 GO:0097060 synaptic membrane(GO:0097060)
0.1 2.8 GO:0033268 node of Ranvier(GO:0033268)
0.0 2.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 2.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.9 2.6 GO:0043512 inhibin A complex(GO:0043512)
0.0 2.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.6 2.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 2.4 GO:0045202 synapse(GO:0045202)
0.2 2.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 2.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 2.2 GO:0030667 secretory granule membrane(GO:0030667)
0.0 2.2 GO:0070382 exocytic vesicle(GO:0070382)
0.7 2.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 2.1 GO:0043196 varicosity(GO:0043196)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 216 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.6 7.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 6.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 5.0 GO:0003924 GTPase activity(GO:0003924)
0.0 4.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.8 3.3 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 3.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 3.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 2.8 GO:0045499 chemorepellent activity(GO:0045499)
0.1 2.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 2.5 GO:0035198 miRNA binding(GO:0035198)
0.1 2.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.5 2.4 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 2.4 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.5 2.3 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.4 2.3 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.4 2.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2 2.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 2.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 4.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 4.9 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.8 PID_ALK1_PATHWAY ALK1 signaling events
0.1 3.5 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 3.4 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 3.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 3.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.7 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 2.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.9 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 1.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.1 PID_INSULIN_PATHWAY Insulin Pathway
0.0 1.0 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 1.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.9 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 5.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 4.2 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.2 3.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 3.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 3.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 2.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 2.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 2.9 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 2.7 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.7 2.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 2.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 2.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 2.0 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.9 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.9 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis