Motif ID: Ikzf2

Z-value: 0.654


Transcription factors associated with Ikzf2:

Gene SymbolEntrez IDGene Name
Ikzf2 ENSMUSG00000025997.7 Ikzf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ikzf2mm10_v2_chr1_-_69685937_696859660.028.9e-01Click!


Activity profile for motif Ikzf2.

activity profile for motif Ikzf2


Sorted Z-values histogram for motif Ikzf2

Sorted Z-values for motif Ikzf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ikzf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 104 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_3270767 5.556 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chrX_+_103422010 5.479 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr5_-_123141067 2.528 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
 AI480526


expressed sequence AI480526


chr1_+_45311538 1.582 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr6_+_4003926 1.554 ENSMUST00000031670.8
 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr11_-_55419898 1.311 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr12_+_75308308 1.264 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr9_-_42944479 1.253 ENSMUST00000114865.1
 Grik4
glutamate receptor, ionotropic, kainate 4
chr2_-_71546745 1.129 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr6_+_15185203 1.000 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr1_-_45503282 0.880 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr5_-_134747241 0.863 ENSMUST00000015138.9
 Eln
elastin
chr1_-_162866502 0.854 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr3_-_116129615 0.832 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr5_-_123140135 0.800 ENSMUST00000160099.1
 AI480526
expressed sequence AI480526
chr2_-_77170592 0.757 ENSMUST00000164114.2
ENSMUST00000049544.7
 Ccdc141

coiled-coil domain containing 141

chr14_+_54936456 0.739 ENSMUST00000037814.6
 Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr16_-_95459245 0.631 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
 Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr5_+_30913398 0.587 ENSMUST00000031055.5
 Emilin1
elastin microfibril interfacer 1
chr3_+_88214474 0.584 ENSMUST00000181356.1
ENSMUST00000181396.1
 Gm3764

predicted gene 3764


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 1.4 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.1 1.3 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.4 1.1 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.1 1.0 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 1.0 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.3 0.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.9 GO:0009404 toxin metabolic process(GO:0009404)
0.1 0.8 GO:0061032 visceral serous pericardium development(GO:0061032)
0.0 0.8 GO:0051642 centrosome localization(GO:0051642)
0.2 0.7 GO:0006710 androgen catabolic process(GO:0006710)
0.0 0.7 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.2 0.6 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.6 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.1 0.6 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441)
0.0 0.6 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.5 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.4 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.4 GO:0048625 myoblast fate commitment(GO:0048625)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 1.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 1.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.3 0.9 GO:0005588 collagen type V trimer(GO:0005588)
0.3 0.9 GO:0071953 elastic fiber(GO:0071953)
0.0 0.6 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 0.5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.4 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)
0.0 0.1 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.4 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 1.3 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 1.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.0 GO:0070888 E-box binding(GO:0070888)
0.2 0.9 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 0.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.7 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.1 0.7 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 0.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.5 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.4 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.4 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.2 GO:0071723 lipopeptide binding(GO:0071723)
0.1 0.2 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.5 NABA_COLLAGENS Genes encoding collagen proteins
0.1 0.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway
0.0 0.3 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.6 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.3 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.9 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors