Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 3.355

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7:

Gene SymbolEntrez IDGene Name
Irf1 ENSMUSG00000018899.10 Irf1
Irf2 ENSMUSG00000031627.7 Irf2
Irf7 ENSMUSG00000025498.8 Irf7
Irf8 ENSMUSG00000041515.3 Irf8
Irf9 ENSMUSG00000002325.8 Irf9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf1mm10_v2_chr11_+_53770458_537705090.563.3e-04Click!
Irf2mm10_v2_chr8_+_46739745_467397910.545.9e-04Click!
Irf8mm10_v2_chr8_+_120736352_1207363850.454.9e-03Click!
Irf7mm10_v2_chr7_-_141266415_1412664810.221.8e-01Click!
Irf9mm10_v2_chr14_+_55604550_556045790.144.1e-01Click!


Activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7.

activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7


Sorted Z-values histogram for motif Irf2_Irf1_Irf8_Irf9_Irf7

Sorted Z-values for motif Irf2_Irf1_Irf8_Irf9_Irf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 41.546 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3027439 39.338 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3023547 37.929 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3017408 37.414 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr2_-_98667264 36.558 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3015654 35.272 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3034599 34.996 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3000922 34.530 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3004457 31.602 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3037111 31.425 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr14_-_19418930 31.319 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3036877 29.638 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3005125 28.135 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3025417 27.228 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3018753 26.116 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr1_-_173942445 25.183 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr2_+_98662227 16.878 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr6_+_121245903 12.887 ENSMUST00000032198.9
 Usp18
ubiquitin specific peptidase 18
chr6_-_39118211 11.490 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr1_+_153751946 11.210 ENSMUST00000183241.1
 Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 237 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 30.2 GO:0035458 cellular response to interferon-beta(GO:0035458)
1.5 26.0 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.8 24.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
5.3 21.2 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
2.4 14.5 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
4.6 13.9 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
2.3 13.7 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.7 12.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.6 12.6 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.6 10.8 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
2.1 10.6 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
0.2 10.4 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
3.4 10.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 9.9 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.9 9.7 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
2.3 9.2 GO:0044565 dendritic cell proliferation(GO:0044565)
3.0 9.1 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.8 8.9 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
2.2 8.8 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
1.0 8.4 GO:0048625 myoblast fate commitment(GO:0048625)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 318.4 GO:0005575 cellular_component(GO:0005575)
0.2 22.6 GO:0016363 nuclear matrix(GO:0016363)
1.7 20.6 GO:0042612 MHC class I protein complex(GO:0042612)
1.3 18.9 GO:0044754 autolysosome(GO:0044754)
0.2 10.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
1.2 10.4 GO:0030478 actin cap(GO:0030478)
3.0 9.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.9 8.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.5 8.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 8.1 GO:0005923 bicellular tight junction(GO:0005923)
1.8 7.1 GO:0061702 inflammasome complex(GO:0061702)
0.1 6.6 GO:0031519 PcG protein complex(GO:0031519)
0.2 6.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.4 4.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
1.1 4.4 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.7 4.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 4.2 GO:0016235 aggresome(GO:0016235)
0.2 3.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 3.7 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.3 3.2 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 54.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 24.1 GO:0019843 rRNA binding(GO:0019843)
0.1 20.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.8 17.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 15.1 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 14.2 GO:0003725 double-stranded RNA binding(GO:0003725)
3.4 13.7 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 12.4 GO:0003924 GTPase activity(GO:0003924)
0.8 10.8 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 10.1 GO:0008083 growth factor activity(GO:0008083)
0.2 10.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 9.9 GO:0003712 transcription cofactor activity(GO:0003712)
0.1 8.9 GO:0046332 SMAD binding(GO:0046332)
0.4 8.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 7.7 GO:0016836 hydro-lyase activity(GO:0016836)
0.3 7.5 GO:0005521 lamin binding(GO:0005521)
0.0 7.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 6.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
1.1 5.7 GO:0050700 CARD domain binding(GO:0050700)
0.8 5.5 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.1 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 8.4 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 6.5 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 6.3 NABA_COLLAGENS Genes encoding collagen proteins
0.1 5.5 PID_PLK1_PATHWAY PLK1 signaling events
0.5 5.2 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 5.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 4.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 3.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 3.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.4 PID_MYC_PATHWAY C-MYC pathway
0.1 3.3 PID_SHP2_PATHWAY SHP2 signaling
0.1 3.0 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 2.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 2.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 1.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 54.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
1.1 15.3 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
2.9 8.7 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 8.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 7.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 6.1 REACTOME_INTERFERON_SIGNALING Genes involved in Interferon Signaling
0.2 5.6 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.4 4.9 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 4.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 4.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 2.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.6 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 2.4 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 2.3 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.2 2.2 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 2.2 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 2.0 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 2.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 1.7 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation