Motif ID: Irf3

Z-value: 0.792


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_44997700-0.076.8e-01Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 75 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_71537402 3.942 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr5_+_114896936 3.220 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
 Oasl2


2'-5' oligoadenylate synthetase-like 2


chr6_-_39118211 2.703 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr4_-_40239779 1.861 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr15_+_32920723 1.850 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr2_+_122147680 1.801 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr11_-_48871408 1.760 ENSMUST00000097271.2
 Irgm1
immunity-related GTPase family M member 1
chr18_-_32559914 1.498 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr11_-_48871344 1.383 ENSMUST00000049519.3
 Irgm1
immunity-related GTPase family M member 1
chr17_+_75178797 1.350 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr13_-_23710714 1.336 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr16_+_35938470 1.282 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr17_+_75178911 1.270 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr3_+_142560052 1.219 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr3_+_81932601 1.150 ENSMUST00000029649.2
 Ctso
cathepsin O
chr16_+_35938972 1.144 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr4_-_40239700 1.114 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr3_+_142560108 1.099 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chr6_-_54972603 1.062 ENSMUST00000060655.8
 Nod1
nucleotide-binding oligomerization domain containing 1
chr7_-_104315455 1.061 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
 Trim12a


tripartite motif-containing 12A



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 5.2 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.0 4.7 GO:0051607 defense response to virus(GO:0051607)
0.2 4.0 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.9 3.8 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.8 3.1 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
0.5 3.1 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.7 3.0 GO:0009597 detection of virus(GO:0009597)
0.1 2.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 1.9 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 1.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.2 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.2 1.1 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.2 1.0 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 0.9 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.1 0.8 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.8 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.5 GO:0055070 copper ion homeostasis(GO:0055070)
0.1 0.4 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.1 0.4 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.6 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.3 3.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 3.1 GO:0044754 autolysosome(GO:0044754)
0.0 3.0 GO:0032587 ruffle membrane(GO:0032587)
0.9 2.6 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 1.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 1.3 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.2 1.0 GO:0008537 proteasome activator complex(GO:0008537)
0.0 1.0 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.3 GO:1990462 omegasome(GO:1990462)
0.0 0.3 GO:0042825 TAP complex(GO:0042825)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 GO:0003924 GTPase activity(GO:0003924)
0.3 5.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 3.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 3.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 3.2 GO:0070566 adenylyltransferase activity(GO:0070566)
0.7 2.6 GO:0050436 microfibril binding(GO:0050436)
0.0 1.9 GO:0030165 PDZ domain binding(GO:0030165)
0.2 1.3 GO:0033592 RNA strand annealing activity(GO:0033592)
0.1 1.3 GO:0039706 co-receptor binding(GO:0039706)
0.0 1.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 1.0 GO:0050700 CARD domain binding(GO:0050700)
0.1 1.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.2 0.9 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 0.7 GO:0031386 protein tag(GO:0031386)
0.0 0.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.5 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.4 GO:0005030 neurotrophin receptor activity(GO:0005030)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.9 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.8 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.7 PID_IL12_2PATHWAY IL12-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.9 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.6 1.8 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 1.0 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.8 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.8 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 0.7 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.7 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.4 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation