Motif ID: Irf4

Z-value: 0.509


Transcription factors associated with Irf4:

Gene SymbolEntrez IDGene Name
Irf4 ENSMUSG00000021356.3 Irf4



Activity profile for motif Irf4.

activity profile for motif Irf4


Sorted Z-values histogram for motif Irf4

Sorted Z-values for motif Irf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_77894096 2.451 ENSMUST00000017597.4
Pipox
pipecolic acid oxidase
chr8_+_84723003 1.805 ENSMUST00000098571.4
G430095P16Rik
RIKEN cDNA G430095P16 gene
chr17_-_6782775 1.667 ENSMUST00000064234.6
Ezr
ezrin
chr17_-_81649607 1.451 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr6_-_39118211 1.354 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr3_+_90537242 1.345 ENSMUST00000098911.3
S100a16
S100 calcium binding protein A16
chr3_+_90537306 1.331 ENSMUST00000107335.1
S100a16
S100 calcium binding protein A16
chr1_-_163313661 1.317 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr1_-_97977233 1.212 ENSMUST00000161567.1
Pam
peptidylglycine alpha-amidating monooxygenase
chr1_-_14310198 1.197 ENSMUST00000168081.2
ENSMUST00000027066.6
Eya1

eyes absent 1 homolog (Drosophila)

chr8_-_84773381 1.136 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr1_+_16688405 1.114 ENSMUST00000026881.4
Ly96
lymphocyte antigen 96
chr5_-_104021919 1.065 ENSMUST00000031251.9
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr9_-_116175318 1.056 ENSMUST00000061101.4
ENSMUST00000035014.6
Tgfbr2

transforming growth factor, beta receptor II

chr6_-_87335758 1.044 ENSMUST00000042025.9
Antxr1
anthrax toxin receptor 1
chr16_+_43235856 0.997 ENSMUST00000146708.1
Zbtb20
zinc finger and BTB domain containing 20
chr5_-_104021799 0.938 ENSMUST00000119025.1
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr11_+_119393060 0.868 ENSMUST00000131035.2
ENSMUST00000093902.5
Rnf213

ring finger protein 213

chr2_+_128126030 0.843 ENSMUST00000089634.5
ENSMUST00000019281.7
ENSMUST00000110341.2
ENSMUST00000103211.1
ENSMUST00000103210.1
Bcl2l11




BCL2-like 11 (apoptosis facilitator)




chr3_+_138065052 0.762 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr2_+_71453276 0.688 ENSMUST00000037210.8
Metap1d
methionyl aminopeptidase type 1D (mitochondrial)
chr16_+_35938972 0.654 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr1_-_84935089 0.598 ENSMUST00000027422.5
Slc16a14
solute carrier family 16 (monocarboxylic acid transporters), member 14
chrX_+_150547375 0.535 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chr16_-_43664145 0.520 ENSMUST00000096065.4
Tigit
T cell immunoreceptor with Ig and ITIM domains
chr14_+_60732906 0.503 ENSMUST00000162945.1
Spata13
spermatogenesis associated 13
chr7_+_35586232 0.494 ENSMUST00000040844.9
Ankrd27
ankyrin repeat domain 27 (VPS9 domain)
chr14_-_66124482 0.492 ENSMUST00000070515.1
Ephx2
epoxide hydrolase 2, cytoplasmic
chr4_-_136886187 0.486 ENSMUST00000046384.8
C1qb
complement component 1, q subcomponent, beta polypeptide
chr16_-_5255923 0.477 ENSMUST00000139584.1
ENSMUST00000064635.5
Fam86

family with sequence similarity 86

chr10_-_18234930 0.453 ENSMUST00000052648.8
ENSMUST00000080860.6
ENSMUST00000173243.1
Ccdc28a


coiled-coil domain containing 28A


chr9_+_64811313 0.435 ENSMUST00000038890.5
Dennd4a
DENN/MADD domain containing 4A
chr8_+_128685654 0.434 ENSMUST00000090006.5
Itgb1
integrin beta 1 (fibronectin receptor beta)
chr13_-_81570640 0.387 ENSMUST00000109565.2
Gpr98
G protein-coupled receptor 98
chr7_-_141010759 0.377 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr2_-_52335134 0.366 ENSMUST00000075301.3
Neb
nebulin
chr18_+_37484955 0.353 ENSMUST00000053856.4
Pcdhb17
protocadherin beta 17
chr10_+_86022189 0.336 ENSMUST00000120344.1
ENSMUST00000117597.1
Fbxo7

F-box protein 7

chr15_-_50889691 0.320 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr12_-_79007276 0.318 ENSMUST00000056660.6
ENSMUST00000174721.1
Tmem229b

transmembrane protein 229B

chr10_-_41490335 0.304 ENSMUST00000019965.6
Smpd2
sphingomyelin phosphodiesterase 2, neutral
chr16_-_26371828 0.302 ENSMUST00000023154.2
Cldn1
claudin 1
chr7_+_4460687 0.301 ENSMUST00000167298.1
ENSMUST00000171445.1
Eps8l1

EPS8-like 1

chr16_-_24393588 0.296 ENSMUST00000181640.1
1110054M08Rik
RIKEN cDNA 1110054M08 gene
chr8_+_90828820 0.280 ENSMUST00000109614.2
ENSMUST00000048665.6
Chd9

chromodomain helicase DNA binding protein 9

chr4_-_156200818 0.280 ENSMUST00000085425.4
Isg15
ISG15 ubiquitin-like modifier
chr7_-_65370908 0.277 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr6_+_71282280 0.270 ENSMUST00000080949.7
Krcc1
lysine-rich coiled-coil 1
chr1_-_93101825 0.270 ENSMUST00000112958.2
Kif1a
kinesin family member 1A
chr2_-_127788854 0.270 ENSMUST00000028857.7
ENSMUST00000110357.1
Nphp1

nephronophthisis 1 (juvenile) homolog (human)

chr10_-_86022325 0.267 ENSMUST00000181665.1
A230060F14Rik
RIKEN cDNA A230060F14 gene
chr2_-_51934644 0.263 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr9_+_45042425 0.260 ENSMUST00000034600.4
Mpzl2
myelin protein zero-like 2
chr1_+_99772765 0.259 ENSMUST00000086738.3
Cntnap5b
contactin associated protein-like 5B
chr10_-_78352323 0.255 ENSMUST00000001240.5
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr11_+_72689997 0.246 ENSMUST00000155998.1
Ankfy1
ankyrin repeat and FYVE domain containing 1
chr10_+_126978690 0.233 ENSMUST00000105256.2
Ctdsp2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr1_-_93101854 0.227 ENSMUST00000171796.1
ENSMUST00000171556.1
Kif1a

kinesin family member 1A

chr3_+_95526777 0.223 ENSMUST00000015667.2
ENSMUST00000116304.2
Ctss

cathepsin S

chr3_-_67375163 0.211 ENSMUST00000166353.1
Gm17402
predicted gene, 17402
chr16_-_55838827 0.210 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr10_-_78351711 0.210 ENSMUST00000105390.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr16_+_24393350 0.204 ENSMUST00000038053.6
Lpp
LIM domain containing preferred translocation partner in lipoma
chr17_+_34564268 0.200 ENSMUST00000015612.7
Notch4
notch 4
chr2_-_66410064 0.199 ENSMUST00000112366.1
Scn1a
sodium channel, voltage-gated, type I, alpha
chr13_-_113046357 0.197 ENSMUST00000022282.3
Gpx8
glutathione peroxidase 8 (putative)
chr11_-_101551837 0.192 ENSMUST00000017290.4
Brca1
breast cancer 1
chr5_+_28165690 0.182 ENSMUST00000036177.7
En2
engrailed 2
chr7_-_16286744 0.172 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
Ccdc9


coiled-coil domain containing 9


chr18_+_7869707 0.172 ENSMUST00000166062.1
ENSMUST00000169010.1
Wac

WW domain containing adaptor with coiled-coil

chr10_-_78351690 0.171 ENSMUST00000166360.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr9_+_65346066 0.166 ENSMUST00000048184.2
Pdcd7
programmed cell death 7
chr10_-_78352053 0.166 ENSMUST00000105388.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr10_+_39612934 0.165 ENSMUST00000019987.6
Traf3ip2
TRAF3 interacting protein 2
chr4_-_89311021 0.164 ENSMUST00000097981.4
Cdkn2b
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chrX_+_136707976 0.163 ENSMUST00000055104.5
Tceal1
transcription elongation factor A (SII)-like 1
chr17_+_34203527 0.157 ENSMUST00000025197.5
Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr4_-_107178282 0.156 ENSMUST00000058585.7
Tceanc2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr12_-_4477138 0.155 ENSMUST00000085814.3
Ncoa1
nuclear receptor coactivator 1
chr14_+_120275669 0.152 ENSMUST00000088419.6
ENSMUST00000167459.1
Mbnl2

muscleblind-like 2

chr5_+_24393640 0.149 ENSMUST00000138168.1
ENSMUST00000115077.1
Abcb8

ATP-binding cassette, sub-family B (MDR/TAP), member 8

chr17_+_8849974 0.147 ENSMUST00000115720.1
Pde10a
phosphodiesterase 10A
chr17_+_47410247 0.146 ENSMUST00000177586.1
Gm5814
predicted pseudogene 5814
chr3_+_89421619 0.139 ENSMUST00000094378.3
ENSMUST00000137793.1
Shc1

src homology 2 domain-containing transforming protein C1

chr16_-_35939082 0.128 ENSMUST00000081933.7
ENSMUST00000114885.1
Dtx3l

deltex 3-like (Drosophila)

chr2_-_9878580 0.128 ENSMUST00000102976.3
Gata3
GATA binding protein 3
chr7_+_105375053 0.116 ENSMUST00000106805.2
Gm5901
predicted gene 5901
chr11_-_101171302 0.116 ENSMUST00000164474.1
ENSMUST00000043397.7
Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr2_+_167062934 0.114 ENSMUST00000125674.1
1500012F01Rik
RIKEN cDNA 1500012F01 gene
chr11_-_107470699 0.101 ENSMUST00000103064.3
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr2_+_147012996 0.097 ENSMUST00000028921.5
Xrn2
5'-3' exoribonuclease 2
chr8_+_105170668 0.094 ENSMUST00000109395.1
ENSMUST00000109394.1
ENSMUST00000052209.2
ENSMUST00000109392.1
Cbfb



core binding factor beta



chr10_-_64090241 0.088 ENSMUST00000133588.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr5_+_36796228 0.085 ENSMUST00000181278.1
Gm26605
predicted gene, 26605
chr12_+_71170589 0.080 ENSMUST00000129376.1
2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr14_+_55578360 0.078 ENSMUST00000174259.1
ENSMUST00000174563.1
ENSMUST00000089619.6
ENSMUST00000172738.1
Psme1



proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)



chr14_+_55578123 0.077 ENSMUST00000174484.1
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr1_-_161876656 0.076 ENSMUST00000048377.5
Suco
SUN domain containing ossification factor
chr3_-_108200807 0.074 ENSMUST00000106655.1
ENSMUST00000065664.6
Cyb561d1

cytochrome b-561 domain containing 1

chr1_-_74588117 0.067 ENSMUST00000066986.6
Zfp142
zinc finger protein 142
chr7_-_126396715 0.067 ENSMUST00000075671.4
Nfatc2ip
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
chr9_+_85842852 0.063 ENSMUST00000098500.3
Tpbg
trophoblast glycoprotein
chr1_+_132008285 0.061 ENSMUST00000146432.1
Elk4
ELK4, member of ETS oncogene family
chrX_-_108834303 0.057 ENSMUST00000101283.3
ENSMUST00000150434.1
Brwd3

bromodomain and WD repeat domain containing 3

chr9_-_108428484 0.056 ENSMUST00000076592.2
Ccdc36
coiled-coil domain containing 36
chr3_+_142496924 0.043 ENSMUST00000090127.2
Gbp5
guanylate binding protein 5
chr1_+_175632169 0.043 ENSMUST00000097458.3
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr13_+_42052015 0.043 ENSMUST00000060148.5
Hivep1
human immunodeficiency virus type I enhancer binding protein 1
chr3_+_152346465 0.038 ENSMUST00000026507.6
ENSMUST00000117492.2
Usp33

ubiquitin specific peptidase 33

chr3_-_142395661 0.038 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
Pdlim5



PDZ and LIM domain 5



chrX_-_95444789 0.036 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr17_-_30612613 0.036 ENSMUST00000167624.1
ENSMUST00000024823.6
Glo1

glyoxalase 1

chr1_+_61638819 0.035 ENSMUST00000138768.1
ENSMUST00000075374.3
Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr14_-_54409469 0.034 ENSMUST00000000984.4
Slc7a7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr1_+_74588347 0.032 ENSMUST00000113732.1
Bcs1l
BCS1-like (yeast)
chr1_+_155558112 0.025 ENSMUST00000080138.6
ENSMUST00000097529.3
ENSMUST00000035560.3
Acbd6


acyl-Coenzyme A binding domain containing 6


chr15_+_102977032 0.022 ENSMUST00000001706.6
Hoxc9
homeobox C9
chr11_+_78245743 0.018 ENSMUST00000002133.8
Sdf2
stromal cell derived factor 2
chr10_-_100589205 0.018 ENSMUST00000054471.8
4930430F08Rik
RIKEN cDNA 4930430F08 gene
chr15_-_97705787 0.015 ENSMUST00000023104.5
Rpap3
RNA polymerase II associated protein 3
chr10_-_111997204 0.013 ENSMUST00000074805.5
Glipr1
GLI pathogenesis-related 1 (glioma)
chr1_+_74588289 0.010 ENSMUST00000113733.3
ENSMUST00000027358.4
Bcs1l

BCS1-like (yeast)

chr19_+_46623387 0.003 ENSMUST00000111855.4
Wbp1l
WW domain binding protein 1 like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0006553 lysine metabolic process(GO:0006553)
0.6 1.7 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.5 2.0 GO:0006710 androgen catabolic process(GO:0006710)
0.4 1.1 GO:0003274 endocardial cushion fusion(GO:0003274)
0.3 1.0 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.3 1.5 GO:0098735 cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735)
0.2 1.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.2 0.8 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.2 1.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 0.6 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.2 0.5 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.1 0.4 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.1 1.3 GO:0048664 neuron fate determination(GO:0048664)
0.1 1.2 GO:0009404 toxin metabolic process(GO:0009404)
0.1 0.9 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.7 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.1 0.2 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.1 1.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.2 GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585)
0.1 0.4 GO:0030832 regulation of actin filament length(GO:0030832)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.3 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.1 GO:0035799 ureter maturation(GO:0035799) cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107) cell-cell signaling involved in metanephros development(GO:0072204) regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.0 0.3 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.0 0.5 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.0 0.2 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 0.5 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.1 GO:1990839 response to endothelin(GO:1990839)
0.0 0.5 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.2 GO:0000429 carbon catabolite regulation of transcription from RNA polymerase II promoter(GO:0000429) carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.0 0.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.4 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 2.7 GO:0051592 response to calcium ion(GO:0051592)
0.0 0.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.0 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.1 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.2 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.0 0.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.2 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.2 GO:0060253 negative regulation of glial cell proliferation(GO:0060253)
0.0 0.2 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.0 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.0 0.0 GO:0032621 interleukin-18 production(GO:0032621)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.2 1.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.4 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)
0.1 1.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.5 GO:0097422 tubular endosome(GO:0097422)
0.1 0.3 GO:1990037 Lewy body core(GO:1990037)
0.1 0.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 2.0 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 1.5 GO:0014704 intercalated disc(GO:0014704)
0.0 1.2 GO:0030667 secretory granule membrane(GO:0030667)
0.0 2.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.4 GO:0005901 caveola(GO:0005901)
0.0 0.4 GO:0005865 striated muscle thin filament(GO:0005865)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.4 1.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.4 1.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.4 1.5 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.3 2.0 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.3 1.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 0.5 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 1.7 GO:0044548 S100 protein binding(GO:0044548)
0.1 0.4 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.5 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 1.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.2 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.0 0.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0048408 epidermal growth factor binding(GO:0048408)
0.0 0.1 GO:0004534 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160) 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.2 GO:0033142 progesterone receptor binding(GO:0033142)
0.0 0.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.8 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.3 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 1.3 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.0 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 1.0 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.1 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.6 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.2 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.1 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 0.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 1.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.6 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.8 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.8 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks