Motif ID: Irf4

Z-value: 0.509


Transcription factors associated with Irf4:

Gene SymbolEntrez IDGene Name
Irf4 ENSMUSG00000021356.3 Irf4



Activity profile for motif Irf4.

activity profile for motif Irf4


Sorted Z-values histogram for motif Irf4

Sorted Z-values for motif Irf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 123 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_77894096 2.451 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr8_+_84723003 1.805 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr17_-_6782775 1.667 ENSMUST00000064234.6
 Ezr
ezrin
chr17_-_81649607 1.451 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr6_-_39118211 1.354 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr3_+_90537242 1.345 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr3_+_90537306 1.331 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr1_-_163313661 1.317 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr1_-_97977233 1.212 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chr1_-_14310198 1.197 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr8_-_84773381 1.136 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr1_+_16688405 1.114 ENSMUST00000026881.4
 Ly96
lymphocyte antigen 96
chr5_-_104021919 1.065 ENSMUST00000031251.9
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr9_-_116175318 1.056 ENSMUST00000061101.4
ENSMUST00000035014.6
 Tgfbr2

transforming growth factor, beta receptor II

chr6_-_87335758 1.044 ENSMUST00000042025.9
 Antxr1
anthrax toxin receptor 1
chr16_+_43235856 0.997 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr5_-_104021799 0.938 ENSMUST00000119025.1
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr11_+_119393060 0.868 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr2_+_128126030 0.843 ENSMUST00000089634.5
ENSMUST00000019281.7
ENSMUST00000110341.2
ENSMUST00000103211.1
ENSMUST00000103210.1
 Bcl2l11




BCL2-like 11 (apoptosis facilitator)




chr3_+_138065052 0.762 ENSMUST00000163080.2
 1110002E22Rik
RIKEN cDNA 1110002E22 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0051592 response to calcium ion(GO:0051592)
0.8 2.5 GO:0006553 lysine metabolic process(GO:0006553)
0.5 2.0 GO:0006710 androgen catabolic process(GO:0006710)
0.6 1.7 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.3 1.5 GO:0098735 cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735)
0.1 1.3 GO:0048664 neuron fate determination(GO:0048664)
0.2 1.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 1.2 GO:0009404 toxin metabolic process(GO:0009404)
0.4 1.1 GO:0003274 endocardial cushion fusion(GO:0003274)
0.2 1.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.1 1.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 1.0 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.1 0.9 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 0.8 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.1 0.7 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.2 0.6 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.2 0.5 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.1 0.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.5 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.0 GO:0005811 lipid particle(GO:0005811)
0.6 1.7 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.0 1.5 GO:0014704 intercalated disc(GO:0014704)
0.0 1.4 GO:0005901 caveola(GO:0005901)
0.0 1.2 GO:0030667 secretory granule membrane(GO:0030667)
0.2 1.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 1.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.5 GO:0097422 tubular endosome(GO:0097422)
0.1 0.4 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)
0.0 0.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.3 GO:1990037 Lewy body core(GO:1990037)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.5 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.3 2.0 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 1.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.7 GO:0044548 S100 protein binding(GO:0044548)
0.4 1.5 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.0 1.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.3 GO:0005518 collagen binding(GO:0005518)
0.4 1.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.4 1.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.3 1.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.8 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.2 0.5 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 0.5 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.4 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.3 GO:0031386 protein tag(GO:0031386)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.1 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.1 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.0 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.6 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.2 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 1.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.1 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.8 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.8 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 0.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 0.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks