Motif ID: Irf5_Irf6

Z-value: 0.661

Transcription factors associated with Irf5_Irf6:

Gene SymbolEntrez IDGene Name
Irf5 ENSMUSG00000029771.6 Irf5
Irf6 ENSMUSG00000026638.9 Irf6



Activity profile for motif Irf5_Irf6.

activity profile for motif Irf5_Irf6


Sorted Z-values histogram for motif Irf5_Irf6

Sorted Z-values for motif Irf5_Irf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf5_Irf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 60 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_141010759 3.997 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr4_-_40239779 3.070 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_39118211 2.675 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr17_-_6782775 2.657 ENSMUST00000064234.6
 Ezr
ezrin
chr16_+_35938972 2.047 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr11_+_88999376 1.942 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
 Trim25


tripartite motif-containing 25


chr19_+_55741810 1.853 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr2_-_77519565 1.811 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr4_-_136886187 1.746 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr4_-_40239700 1.555 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr1_-_163313661 1.216 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr3_+_138065052 0.954 ENSMUST00000163080.2
 1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr15_+_9436028 0.816 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr9_+_45042425 0.801 ENSMUST00000034600.4
 Mpzl2
myelin protein zero-like 2
chr16_+_35938470 0.740 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr7_+_128523576 0.694 ENSMUST00000033136.7
 Bag3
BCL2-associated athanogene 3
chr7_+_49246131 0.648 ENSMUST00000064395.6
 Nav2
neuron navigator 2
chr2_-_77170592 0.561 ENSMUST00000164114.2
ENSMUST00000049544.7
 Ccdc141

coiled-coil domain containing 141

chr12_-_31950210 0.542 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
 Hbp1


high mobility group box transcription factor 1


chrX_+_77511002 0.535 ENSMUST00000088217.5
 Tbl1x
transducin (beta)-like 1 X-linked

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.9 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
1.2 4.6 GO:0009597 detection of virus(GO:0009597)
0.3 2.8 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.9 2.7 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.2 1.9 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 1.8 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 1.7 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.3 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1 1.2 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.7 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 0.6 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.0 0.6 GO:0034340 response to type I interferon(GO:0034340)
0.0 0.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.6 GO:0051642 centrosome localization(GO:0051642)
0.1 0.4 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.1 0.4 GO:0032439 endosome localization(GO:0032439) positive regulation of pinocytosis(GO:0048549)
0.0 0.4 GO:1900225 NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225)
0.1 0.3 GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489)
0.0 0.3 GO:0008343 adult feeding behavior(GO:0008343)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 4.0 GO:0045177 apical part of cell(GO:0045177)
0.9 2.7 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.2 1.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.8 GO:0001650 fibrillar center(GO:0001650)
0.0 1.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.4 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.3 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 4.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 2.7 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.9 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 1.9 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 1.8 GO:0002039 p53 binding(GO:0002039)
0.0 1.2 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.6 GO:0048038 quinone binding(GO:0048038)
0.1 0.4 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 0.4 GO:0016936 galactoside binding(GO:0016936)
0.1 0.3 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.1 0.3 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 0.3 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.1 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.3 PID_MYC_PATHWAY C-MYC pathway
0.0 0.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.7 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 4.0 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.7 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.3 1.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins