Motif ID: Irx5

Z-value: 0.546


Transcription factors associated with Irx5:

Gene SymbolEntrez IDGene Name
Irx5 ENSMUSG00000031737.10 Irx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.429.3e-03Click!


Activity profile for motif Irx5.

activity profile for motif Irx5


Sorted Z-values histogram for motif Irx5

Sorted Z-values for motif Irx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_139543889 3.075 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_79908428 2.076 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr2_-_79908389 1.621 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr6_+_50110837 1.386 ENSMUST00000167628.1
 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr12_+_55598917 1.298 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr12_-_67222549 1.271 ENSMUST00000037181.8
 Mdga2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr14_+_48120841 1.087 ENSMUST00000073150.4
 Peli2
pellino 2
chr7_-_114927726 1.087 ENSMUST00000059737.2
 Gm6816
predicted gene 6816
chr19_+_26623419 1.040 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr14_-_19977040 0.994 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr1_+_165301863 0.985 ENSMUST00000178700.1
 Gpr161
G protein-coupled receptor 161
chr14_-_19977151 0.972 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr2_-_85035487 0.959 ENSMUST00000028465.7
 P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
chr3_+_124321031 0.956 ENSMUST00000058994.4
 Tram1l1
translocation associated membrane protein 1-like 1
chr3_-_126998408 0.821 ENSMUST00000182764.1
ENSMUST00000044443.8
 Ank2

ankyrin 2, brain

chr2_-_101621033 0.755 ENSMUST00000090513.4
 B230118H07Rik
RIKEN cDNA B230118H07 gene
chr14_-_19977249 0.744 ENSMUST00000160013.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr1_-_78968079 0.700 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr12_-_108893197 0.666 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr10_-_13868779 0.649 ENSMUST00000105534.3
 Aig1
androgen-induced 1
chr12_+_38783503 0.632 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr9_-_78378725 0.567 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr5_-_88675190 0.564 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr4_-_49521036 0.548 ENSMUST00000057829.3
 Mrpl50
mitochondrial ribosomal protein L50
chr10_-_99759658 0.526 ENSMUST00000056085.4
 Csl
citrate synthase like
chr12_-_99393010 0.487 ENSMUST00000177451.1
 Foxn3
forkhead box N3
chr4_+_43632185 0.478 ENSMUST00000107874.2
 Npr2
natriuretic peptide receptor 2
chr11_-_28339867 0.467 ENSMUST00000042595.6
 Gm6685
predicted pseudogene 6685
chr4_+_43631935 0.449 ENSMUST00000030191.8
 Npr2
natriuretic peptide receptor 2
chr10_+_3872667 0.445 ENSMUST00000136671.1
ENSMUST00000042438.6
 Plekhg1

pleckstrin homology domain containing, family G (with RhoGef domain) member 1

chr11_-_68927049 0.440 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr7_-_98112618 0.440 ENSMUST00000153657.1
 Myo7a
myosin VIIA
chr3_+_95124476 0.427 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
 Tmod4


tropomodulin 4


chr16_-_55838827 0.404 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
 Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr7_+_45785331 0.399 ENSMUST00000120005.1
ENSMUST00000123585.1
 Lmtk3

lemur tyrosine kinase 3

chr11_-_69395333 0.396 ENSMUST00000108660.1
ENSMUST00000051620.4
 Cyb5d1

cytochrome b5 domain containing 1

chr17_+_21657582 0.386 ENSMUST00000039726.7
 3110052M02Rik
RIKEN cDNA 3110052M02 gene
chr4_-_59783800 0.361 ENSMUST00000107526.1
ENSMUST00000095063.4
 Inip

INTS3 and NABP interacting protein

chr16_+_33185045 0.342 ENSMUST00000039733.8
 Osbpl11
oxysterol binding protein-like 11
chr1_-_169969143 0.311 ENSMUST00000027989.6
ENSMUST00000111353.3
 Hsd17b7

hydroxysteroid (17-beta) dehydrogenase 7

chr12_+_69893105 0.291 ENSMUST00000021466.8
 Atl1
atlastin GTPase 1
chr4_-_43653560 0.289 ENSMUST00000107870.2
 Spag8
sperm associated antigen 8
chr4_+_148039097 0.288 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chrX_+_135742686 0.267 ENSMUST00000113144.1
ENSMUST00000113147.1
ENSMUST00000113145.1
ENSMUST00000096321.2
 Gprasp1


Armcx5
G protein-coupled receptor associated sorting protein 1


armadillo repeat containing, X-linked 5
chr4_+_6365650 0.258 ENSMUST00000029912.4
ENSMUST00000103008.5
ENSMUST00000175769.1
ENSMUST00000108374.1
ENSMUST00000140830.1
 Sdcbp




syndecan binding protein




chr3_+_63963631 0.250 ENSMUST00000181653.1
 Gm26850
predicted gene, 26850
chr11_+_69098937 0.239 ENSMUST00000021271.7
 Per1
period circadian clock 1
chr16_-_56024628 0.234 ENSMUST00000119981.1
ENSMUST00000096021.3
 Pcnp

PEST proteolytic signal containing nuclear protein

chr8_+_85171322 0.227 ENSMUST00000076896.5
 Gm6531
predicted gene 6531
chr11_-_69579320 0.226 ENSMUST00000048139.5
 Wrap53
WD repeat containing, antisense to Trp53
chr4_-_43653542 0.222 ENSMUST00000084646.4
 Spag8
sperm associated antigen 8
chr10_-_88146867 0.220 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr14_-_14120904 0.220 ENSMUST00000022256.3
 Psmd6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr12_-_85288419 0.209 ENSMUST00000121930.1
 Acyp1
acylphosphatase 1, erythrocyte (common) type
chr10_+_79960145 0.197 ENSMUST00000045247.7
 Wdr18
WD repeat domain 18
chr2_-_73625731 0.189 ENSMUST00000070579.6
 Chn1
chimerin (chimaerin) 1
chr10_+_97565436 0.183 ENSMUST00000038160.4
 Lum
lumican
chr2_+_152427639 0.173 ENSMUST00000128737.1
 6820408C15Rik
RIKEN cDNA 6820408C15 gene
chr10_+_88146992 0.167 ENSMUST00000052355.7
 Nup37
nucleoporin 37
chr13_+_24943144 0.151 ENSMUST00000021773.5
 Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr14_+_48446340 0.107 ENSMUST00000111735.2
 Tmem260
transmembrane protein 260
chr5_+_23787691 0.090 ENSMUST00000030852.6
ENSMUST00000120869.1
ENSMUST00000117783.1
ENSMUST00000115113.2
 Rint1



RAD50 interactor 1



chr9_+_78051938 0.083 ENSMUST00000024104.7
 Gcm1
glial cells missing homolog 1 (Drosophila)
chr2_+_104027823 0.066 ENSMUST00000111135.1
ENSMUST00000111136.1
ENSMUST00000102565.3
 Fbxo3


F-box protein 3


chr1_-_132707304 0.040 ENSMUST00000043189.7
 Nfasc
neurofascin
chr9_-_7835255 0.040 ENSMUST00000074246.6
 Birc2
baculoviral IAP repeat-containing 2
chr18_+_76944384 0.031 ENSMUST00000156454.1
ENSMUST00000150990.1
ENSMUST00000026485.7
ENSMUST00000148955.1
 Hdhd2



haloacid dehalogenase-like hydrolase domain containing 2



chr10_+_11609256 0.028 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr17_+_87025550 0.027 ENSMUST00000024959.3
ENSMUST00000160269.1
 Cript

cysteine-rich PDZ-binding protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.3 1.0 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.2 0.7 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 3.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 1.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.9 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.8 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 1.0 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 0.3 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.3 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.4 GO:0050957 equilibrioception(GO:0050957)
0.1 0.3 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.1 0.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507)
0.0 0.2 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.2 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.2 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.1 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.0 0.5 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.0 GO:1902527 positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.6 GO:0007566 embryo implantation(GO:0007566)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002139 stereocilia coupling link(GO:0002139)
0.1 0.6 GO:0012505 endomembrane system(GO:0012505)
0.1 0.4 GO:0070876 SOSS complex(GO:0070876)
0.1 1.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 2.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.4 GO:0001520 outer dense fiber(GO:0001520)
0.1 1.0 GO:0071564 npBAF complex(GO:0071564)
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.8 GO:0031430 M band(GO:0031430)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.7 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 0.7 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 0.9 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 1.0 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2 2.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.3 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 0.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 1.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0045545 syndecan binding(GO:0045545)
0.0 0.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.2 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)
0.0 0.0 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.2 GO:0070034 telomerase RNA binding(GO:0070034)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.1 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.7 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis