Motif ID: Irx6_Irx2_Irx3

Z-value: 0.608

Transcription factors associated with Irx6_Irx2_Irx3:

Gene SymbolEntrez IDGene Name
Irx2 ENSMUSG00000001504.9 Irx2
Irx3 ENSMUSG00000031734.11 Irx3
Irx6 ENSMUSG00000031738.8 Irx6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx2mm10_v2_chr13_+_72632597_72632625-0.401.4e-02Click!
Irx6mm10_v2_chr8_+_92674826_92674826-0.134.6e-01Click!
Irx3mm10_v2_chr8_-_91801948_91802067-0.105.6e-01Click!


Activity profile for motif Irx6_Irx2_Irx3.

activity profile for motif Irx6_Irx2_Irx3


Sorted Z-values histogram for motif Irx6_Irx2_Irx3

Sorted Z-values for motif Irx6_Irx2_Irx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_125328957 3.918 ENSMUST00000063318.2
 Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr1_+_45311538 3.523 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr7_-_112159034 2.965 ENSMUST00000033036.5
 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr16_+_17146937 2.739 ENSMUST00000115706.1
ENSMUST00000069064.4
 Ydjc

YdjC homolog (bacterial)

chr8_+_36489191 2.464 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr9_-_112232449 2.322 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr13_+_76579670 2.075 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr14_-_30353468 1.620 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr9_-_124493793 1.565 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr1_+_159737510 1.563 ENSMUST00000111669.3
 Tnr
tenascin R
chr18_+_35770318 1.460 ENSMUST00000165299.1
 Gm16490
predicted gene 16490
chr7_+_19212521 1.369 ENSMUST00000060225.4
 Gpr4
G protein-coupled receptor 4
chr13_+_16014457 1.367 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr7_-_103827922 1.366 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr6_-_56901870 1.190 ENSMUST00000101367.2
 Nt5c3
5'-nucleotidase, cytosolic III
chr2_-_119271202 1.174 ENSMUST00000037360.7
 Rhov
ras homolog gene family, member V
chr18_-_31820413 1.150 ENSMUST00000165131.2
 Gm6665
predicted gene 6665
chr6_-_48708206 1.091 ENSMUST00000119315.1
ENSMUST00000053661.4
 Gimap6

GTPase, IMAP family member 6

chr11_+_43474276 1.075 ENSMUST00000173002.1
ENSMUST00000057679.3
 C1qtnf2

C1q and tumor necrosis factor related protein 2

chr13_+_49504774 1.056 ENSMUST00000051504.7
 Ecm2
extracellular matrix protein 2, female organ and adipocyte specific

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.9 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.7 3.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.6 3.1 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.1 2.7 GO:0034605 cellular response to heat(GO:0034605)
0.2 2.5 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.4 1.6 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.4 1.6 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.3 1.4 GO:0072008 glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.3 1.4 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 1.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 1.2 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 1.0 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 1.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.0 GO:0007601 visual perception(GO:0007601)
0.3 0.9 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.2 0.9 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 0.8 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.7 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 0.7 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 2.0 GO:0005581 collagen trimer(GO:0005581)
0.0 1.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.5 1.6 GO:0072534 perineuronal net(GO:0072534)
0.2 1.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.5 1.4 GO:0043512 inhibin A complex(GO:0043512)
0.3 1.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.3 1.0 GO:0000801 central element(GO:0000801)
0.1 1.0 GO:0097431 mitotic spindle pole(GO:0097431)
0.2 0.9 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.8 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.8 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.6 GO:0046930 pore complex(GO:0046930)
0.1 0.5 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.5 GO:0005687 U4 snRNP(GO:0005687)
0.1 0.4 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.4 GO:0016035 zeta DNA polymerase complex(GO:0016035)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.0 3.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.4 2.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 1.6 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 1.6 GO:0046625 sphingolipid binding(GO:0046625)
0.3 1.4 GO:0031720 haptoglobin binding(GO:0031720)
0.2 1.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.4 1.1 GO:0070052 collagen V binding(GO:0070052)
0.2 1.0 GO:0019841 retinol binding(GO:0019841)
0.0 0.8 GO:0043022 ribosome binding(GO:0043022)
0.1 0.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)
0.0 0.6 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.6 GO:0015485 cholesterol binding(GO:0015485)
0.2 0.5 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.2 0.5 GO:0072541 peroxynitrite reductase activity(GO:0072541)
0.1 0.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 2.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.4 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.3 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.9 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 3.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 1.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.2 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.2 1.0 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 0.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.8 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.5 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.0 0.5 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.4 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type