Motif ID: Isl1

Z-value: 0.370


Transcription factors associated with Isl1:

Gene SymbolEntrez IDGene Name
Isl1 ENSMUSG00000042258.7 Isl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_116309699-0.521.1e-03Click!


Activity profile for motif Isl1.

activity profile for motif Isl1


Sorted Z-values histogram for motif Isl1

Sorted Z-values for motif Isl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 121 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56978534 2.731 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr15_-_93519499 1.458 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr9_-_112187898 1.420 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr3_-_49757257 1.382 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr9_-_40346290 1.332 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr3_+_89520152 1.296 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr8_+_84723003 1.255 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chrX_+_99975570 1.023 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
 Eda








ectodysplasin-A








chr4_-_14621805 0.993 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr6_-_144209558 0.948 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr6_-_144209471 0.941 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr2_+_67748212 0.936 ENSMUST00000180887.1
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr6_-_144209448 0.933 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr12_-_12941827 0.856 ENSMUST00000043396.7
 Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr9_-_112217261 0.827 ENSMUST00000159451.1
ENSMUST00000162796.1
ENSMUST00000161097.1
 Arpp21


cyclic AMP-regulated phosphoprotein, 21


chrX_+_153237466 0.822 ENSMUST00000143880.1
 Klf8
Kruppel-like factor 8
chr8_-_105568298 0.800 ENSMUST00000005849.5
 Agrp
agouti related protein
chr18_-_15718046 0.701 ENSMUST00000053017.6
 Chst9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr18_-_35215008 0.681 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr9_+_53771499 0.645 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 2.8 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 2.7 GO:0034605 cellular response to heat(GO:0034605)
0.3 2.1 GO:0019532 oxalate transport(GO:0019532)
0.5 1.5 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.1 1.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.3 1.0 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.9 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.8 GO:0008343 adult feeding behavior(GO:0008343)
0.1 0.7 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.7 GO:0043171 peptide catabolic process(GO:0043171)
0.2 0.6 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.1 0.6 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.6 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.5 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 0.4 GO:0006597 spermine biosynthetic process(GO:0006597)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.2 GO:0016235 aggresome(GO:0016235)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.0 1.0 GO:0005581 collagen trimer(GO:0005581)
0.1 0.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0097513 myosin II filament(GO:0097513)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0005516 calmodulin binding(GO:0005516)
0.2 2.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.3 1.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 1.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 0.9 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.9 GO:0030507 spectrin binding(GO:0030507)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 0.7 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.5 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.4 GO:0019808 polyamine binding(GO:0019808)
0.1 0.4 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.2 GO:0004829 threonine-tRNA ligase activity(GO:0004829)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.7 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.6 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.5 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.4 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.2 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.2 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha