Motif ID: Klf1

Z-value: 2.837


Transcription factors associated with Klf1:

Gene SymbolEntrez IDGene Name
Klf1 ENSMUSG00000054191.7 Klf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf1mm10_v2_chr8_+_84901928_84901992-0.372.2e-02Click!


Activity profile for motif Klf1.

activity profile for motif Klf1


Sorted Z-values histogram for motif Klf1

Sorted Z-values for motif Klf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 19.148 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr5_-_139325616 18.900 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr4_+_47208005 16.916 ENSMUST00000082303.6
ENSMUST00000102917.4
 Col15a1

collagen, type XV, alpha 1

chr7_+_44310213 14.009 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr9_-_107710475 13.866 ENSMUST00000080560.3
 Sema3f
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr14_+_70554056 13.702 ENSMUST00000022691.7
 Hr
hairless
chr12_+_108334341 13.584 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr15_+_83791939 13.384 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr12_-_4841583 13.335 ENSMUST00000020964.5
 Fkbp1b
FK506 binding protein 1b
chr19_+_4099998 13.250 ENSMUST00000049658.7
 Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr10_-_81025521 12.736 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr8_+_93810832 12.399 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr17_-_26201328 12.297 ENSMUST00000025019.2
 Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr19_+_37550397 11.974 ENSMUST00000066439.6
 Exoc6
exocyst complex component 6
chr7_-_103813913 11.888 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr2_+_180499893 11.459 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr15_-_37791993 11.376 ENSMUST00000168992.1
ENSMUST00000148652.1
 Ncald

neurocalcin delta

chr2_+_92599671 11.264 ENSMUST00000065797.6
 Chst1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr5_+_130448801 10.979 ENSMUST00000111288.2
 Caln1
calneuron 1
chr11_+_104231465 10.916 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 651 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 38.8 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.3 31.4 GO:0071805 potassium ion transmembrane transport(GO:0071805)
2.6 23.5 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
2.2 21.6 GO:0010459 negative regulation of heart rate(GO:0010459)
0.3 21.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.7 18.8 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
1.3 17.9 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
1.7 17.3 GO:0046959 habituation(GO:0046959)
0.2 15.3 GO:0030032 lamellipodium assembly(GO:0030032)
2.9 14.6 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.4 14.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.5 14.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
1.4 13.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
2.6 12.9 GO:1902287 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.6 12.9 GO:0021681 cerebellar granular layer development(GO:0021681)
0.8 12.7 GO:0033623 regulation of integrin activation(GO:0033623)
4.1 12.2 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
1.5 12.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
3.0 12.0 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.7 11.8 GO:0033169 histone H3-K9 demethylation(GO:0033169)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 267 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 44.5 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.2 42.5 GO:0045211 postsynaptic membrane(GO:0045211)
3.8 38.2 GO:0045298 tubulin complex(GO:0045298)
0.2 33.7 GO:0000139 Golgi membrane(GO:0000139)
0.6 30.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 29.6 GO:0099572 postsynaptic specialization(GO:0099572)
0.2 26.9 GO:0070382 exocytic vesicle(GO:0070382)
0.4 25.6 GO:0005581 collagen trimer(GO:0005581)
0.4 22.5 GO:0031941 filamentous actin(GO:0031941)
0.8 20.8 GO:0071565 nBAF complex(GO:0071565)
1.2 20.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.4 19.6 GO:0016235 aggresome(GO:0016235)
6.4 19.1 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
4.6 18.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 17.5 GO:0043204 perikaryon(GO:0043204)
0.9 17.4 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
1.5 16.9 GO:0032426 stereocilium tip(GO:0032426)
0.2 16.9 GO:0005770 late endosome(GO:0005770)
0.1 16.6 GO:0043025 neuronal cell body(GO:0043025)
5.4 16.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 391 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.3 37.4 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 35.6 GO:0005096 GTPase activator activity(GO:0005096)
0.1 29.7 GO:0003924 GTPase activity(GO:0003924)
0.4 24.6 GO:0030276 clathrin binding(GO:0030276)
3.1 21.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.3 21.3 GO:0045504 dynein heavy chain binding(GO:0045504)
4.9 19.6 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.4 19.5 GO:0015485 cholesterol binding(GO:0015485)
0.4 19.0 GO:0005267 potassium channel activity(GO:0005267)
1.3 18.8 GO:0031005 filamin binding(GO:0031005)
4.6 18.3 GO:0031720 haptoglobin binding(GO:0031720)
1.0 18.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.4 17.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 17.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 17.4 GO:0030165 PDZ domain binding(GO:0030165)
1.1 16.1 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.8 15.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.2 15.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
3.7 14.6 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
2.0 14.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 40.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.7 32.0 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.7 28.4 PID_ARF6_PATHWAY Arf6 signaling events
0.6 27.1 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.3 24.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 21.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
1.2 20.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 19.3 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.4 14.4 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.3 12.7 PID_INSULIN_PATHWAY Insulin Pathway
0.4 11.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.4 11.1 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.4 10.9 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.2 8.9 PID_SHP2_PATHWAY SHP2 signaling
0.3 7.9 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 7.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 7.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 6.6 PID_P53_REGULATION_PATHWAY p53 pathway
0.2 6.3 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.6 5.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 44.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.9 42.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.8 33.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 30.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
1.0 26.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.6 25.8 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.4 21.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.5 18.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.6 17.7 REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM Genes involved in Keratan sulfate/keratin metabolism
0.8 16.7 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.5 16.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.6 15.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.6 14.9 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 14.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.6 13.9 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
2.0 13.7 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.6 12.9 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.4 12.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.2 12.1 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
1.2 11.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors