Motif ID: Klf12_Klf14_Sp4

Z-value: 1.360

Transcription factors associated with Klf12_Klf14_Sp4:

Gene SymbolEntrez IDGene Name
Klf12 ENSMUSG00000072294.4 Klf12
Klf14 ENSMUSG00000073209.3 Klf14
Sp4 ENSMUSG00000025323.9 Sp4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf12mm10_v2_chr14_-_100149764_1001497640.473.3e-03Click!
Sp4mm10_v2_chr12_-_118301429_1183014580.334.8e-02Click!


Activity profile for motif Klf12_Klf14_Sp4.

activity profile for motif Klf12_Klf14_Sp4


Sorted Z-values histogram for motif Klf12_Klf14_Sp4

Sorted Z-values for motif Klf12_Klf14_Sp4



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf12_Klf14_Sp4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_25622525 9.706 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr9_+_80165079 9.247 ENSMUST00000184480.1
 Myo6
myosin VI
chr5_-_99252839 8.900 ENSMUST00000168092.1
ENSMUST00000031276.8
 Rasgef1b

RasGEF domain family, member 1B

chr15_-_58076456 8.788 ENSMUST00000070143.6
ENSMUST00000110168.1
 Zhx1

zinc fingers and homeoboxes 1

chr9_+_80165013 8.362 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr14_+_60634719 8.317 ENSMUST00000022566.7
ENSMUST00000159729.1
 Spata13

spermatogenesis associated 13

chr5_-_140389188 6.765 ENSMUST00000031539.7
 Snx8
sorting nexin 8
chr4_+_137468767 5.786 ENSMUST00000030547.8
ENSMUST00000171332.1
 Hspg2

perlecan (heparan sulfate proteoglycan 2)

chr18_+_64340225 5.571 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr7_+_107595051 5.410 ENSMUST00000040056.7
 Ppfibp2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_+_57249450 5.132 ENSMUST00000019631.9
 Trip10
thyroid hormone receptor interactor 10
chr13_-_49215978 5.111 ENSMUST00000048946.6
 1110007C09Rik
RIKEN cDNA 1110007C09 gene
chr2_+_172345565 4.553 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr13_+_92611119 4.551 ENSMUST00000049488.7
 Serinc5
serine incorporator 5
chr11_+_62077018 4.392 ENSMUST00000092415.5
 Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr5_-_115119277 4.347 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr2_+_79635352 4.035 ENSMUST00000111785.2
 Ssfa2
sperm specific antigen 2
chr15_-_32244632 3.968 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr4_-_22488296 3.963 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr2_+_79635416 3.784 ENSMUST00000111788.1
 Ssfa2
sperm specific antigen 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 669 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 14.6 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.6 8.4 GO:0001675 acrosome assembly(GO:0001675)
0.8 7.4 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.1 7.1 GO:0046847 filopodium assembly(GO:0046847)
0.8 6.7 GO:0010032 meiotic chromosome condensation(GO:0010032)
2.2 6.6 GO:0006601 creatine biosynthetic process(GO:0006601)
0.6 6.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.7 6.1 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.5 6.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.5 5.8 GO:0034498 early endosome to Golgi transport(GO:0034498)
1.4 5.7 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.1 5.7 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.5 5.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 5.0 GO:0048199 vesicle targeting, to, from or within Golgi(GO:0048199)
0.1 4.9 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.3 4.7 GO:0035493 SNARE complex assembly(GO:0035493)
0.6 4.6 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.4 4.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.2 4.4 GO:0002115 store-operated calcium entry(GO:0002115)
1.1 4.3 GO:0009597 detection of virus(GO:0009597)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 247 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 24.3 GO:0030175 filopodium(GO:0030175)
0.5 13.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 10.6 GO:0005615 extracellular space(GO:0005615)
0.0 10.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 10.2 GO:0001726 ruffle(GO:0001726)
0.5 10.1 GO:0002080 acrosomal membrane(GO:0002080)
0.7 7.3 GO:0000796 condensin complex(GO:0000796)
0.3 7.2 GO:0005605 basal lamina(GO:0005605)
0.1 6.1 GO:0031519 PcG protein complex(GO:0031519)
0.0 5.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 5.6 GO:0031231 intrinsic component of peroxisomal membrane(GO:0031231)
0.2 5.5 GO:0030904 retromer complex(GO:0030904)
0.1 5.3 GO:0005814 centriole(GO:0005814)
0.3 5.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 4.9 GO:0045171 intercellular bridge(GO:0045171)
0.3 4.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.4 4.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.3 4.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.8 4.0 GO:0097149 centralspindlin complex(GO:0097149)
0.1 3.9 GO:0034358 plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 395 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 46.1 GO:0051015 actin filament binding(GO:0051015)
0.1 16.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 13.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 8.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 7.4 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 6.6 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.1 6.4 GO:0004540 ribonuclease activity(GO:0004540)
0.6 5.6 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.3 5.1 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 5.0 GO:0002020 protease binding(GO:0002020)
0.4 4.9 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 4.7 GO:0071837 HMG box domain binding(GO:0071837)
0.0 4.7 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.8 4.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
1.0 4.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 4.2 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.7 4.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.3 4.0 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
1.3 3.9 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.2 3.9 GO:0070016 armadillo repeat domain binding(GO:0070016)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 23.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.3 11.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 9.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 7.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.4 7.7 ST_STAT3_PATHWAY STAT3 Pathway
0.2 6.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.2 6.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 6.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 6.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 6.2 PID_BMP_PATHWAY BMP receptor signaling
0.1 5.1 PID_E2F_PATHWAY E2F transcription factor network
0.1 4.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 4.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.2 3.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 3.1 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 2.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 2.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.6 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 10.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.5 7.8 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 6.8 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.6 6.7 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 6.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.5 6.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 6.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 5.7 REACTOME_KINESINS Genes involved in Kinesins
0.1 5.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 5.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 4.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 4.5 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 4.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.4 4.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 4.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 4.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 3.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 3.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions