Motif ID: Klf13

Z-value: 0.397


Transcription factors associated with Klf13:

Gene SymbolEntrez IDGene Name
Klf13 ENSMUSG00000052040.9 Klf13

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf13mm10_v2_chr7_-_63938862_639389330.029.2e-01Click!


Activity profile for motif Klf13.

activity profile for motif Klf13


Sorted Z-values histogram for motif Klf13

Sorted Z-values for motif Klf13



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf13

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_56722372 1.426 ENSMUST00000038949.4
 Adrb1
adrenergic receptor, beta 1
chr17_+_87282880 1.056 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr17_-_87282771 0.923 ENSMUST00000161759.1
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr15_-_64922290 0.768 ENSMUST00000023007.5
 Adcy8
adenylate cyclase 8
chr4_+_136143497 0.717 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr17_-_87282793 0.697 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr18_+_37955544 0.623 ENSMUST00000070709.2
ENSMUST00000177058.1
ENSMUST00000169360.2
ENSMUST00000163591.2
ENSMUST00000091932.5
 Rell2




RELT-like 2




chr11_+_70026815 0.605 ENSMUST00000135916.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr18_+_37955126 0.585 ENSMUST00000176902.1
ENSMUST00000176104.1
 Rell2

RELT-like 2

chr5_+_35757875 0.490 ENSMUST00000101280.3
ENSMUST00000054598.5
ENSMUST00000114205.1
ENSMUST00000114206.2
 Ablim2



actin-binding LIM protein 2



chr12_-_14152038 0.470 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chr14_+_54426902 0.462 ENSMUST00000010550.7
 Mrpl52
mitochondrial ribosomal protein L52
chr19_-_42129043 0.407 ENSMUST00000018965.3
 Avpi1
arginine vasopressin-induced 1
chr7_+_19181159 0.404 ENSMUST00000120595.1
ENSMUST00000048502.8
 Eml2

echinoderm microtubule associated protein like 2

chr8_+_3631109 0.403 ENSMUST00000004745.8
 Stxbp2
syntaxin binding protein 2
chr15_+_85037062 0.376 ENSMUST00000023069.7
 Fam118a
family with sequence similarity 118, member A
chr10_-_62340514 0.365 ENSMUST00000099691.4
 Hk1
hexokinase 1
chr12_-_79172609 0.365 ENSMUST00000055262.6
 Vti1b
vesicle transport through interaction with t-SNAREs 1B
chr8_+_83608175 0.333 ENSMUST00000005620.8
 Dnajb1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr6_-_82652856 0.325 ENSMUST00000160281.1
ENSMUST00000095786.5
 Pole4

polymerase (DNA-directed), epsilon 4 (p12 subunit)

chr4_-_117133953 0.322 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr10_-_81167896 0.314 ENSMUST00000005064.7
 Pias4
protein inhibitor of activated STAT 4
chr14_+_70100083 0.304 ENSMUST00000022680.7
 Bin3
bridging integrator 3
chr5_-_138263942 0.295 ENSMUST00000048421.7
ENSMUST00000164203.1
 BC037034
BC037034
cDNA sequence BC037034
cDNA sequence BC037034
chr17_+_56717759 0.277 ENSMUST00000002452.6
 Ndufa11
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
chr6_+_83795205 0.271 ENSMUST00000113850.1
 Nagk
N-acetylglucosamine kinase
chr18_+_67343564 0.270 ENSMUST00000025404.8
 Cidea
cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
chr8_-_94876269 0.267 ENSMUST00000046461.7
 Dok4
docking protein 4
chr2_+_167538192 0.261 ENSMUST00000052631.7
 Snai1
snail homolog 1 (Drosophila)
chr13_-_49215978 0.257 ENSMUST00000048946.6
 1110007C09Rik
RIKEN cDNA 1110007C09 gene
chr19_-_42128982 0.256 ENSMUST00000161873.1
 Avpi1
arginine vasopressin-induced 1
chr10_-_81378459 0.237 ENSMUST00000140901.1
 Fzr1
fizzy/cell division cycle 20 related 1 (Drosophila)
chr5_-_137502402 0.232 ENSMUST00000111035.1
ENSMUST00000031728.4
 Pop7

processing of precursor 7, ribonuclease P family, (S. cerevisiae)

chr6_+_83794974 0.226 ENSMUST00000037376.7
 Nagk
N-acetylglucosamine kinase
chr17_-_35910032 0.219 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
 Atat1




alpha tubulin acetyltransferase 1




chr7_+_27447978 0.217 ENSMUST00000037399.9
ENSMUST00000108358.1
 Blvrb

biliverdin reductase B (flavin reductase (NADPH))

chr6_+_83795022 0.214 ENSMUST00000113851.1
 Nagk
N-acetylglucosamine kinase
chr3_-_90509450 0.213 ENSMUST00000107343.1
ENSMUST00000001043.7
ENSMUST00000107344.1
ENSMUST00000076639.4
ENSMUST00000107346.1
ENSMUST00000146740.1
ENSMUST00000107342.1
ENSMUST00000049937.6
 Chtop







chromatin target of PRMT1







chr5_-_138264013 0.213 ENSMUST00000161604.1
ENSMUST00000163268.1
 BC037034
BC037034
cDNA sequence BC037034
cDNA sequence BC037034
chr7_-_16874845 0.207 ENSMUST00000181501.1
 9330104G04Rik
RIKEN cDNA 9330104G04 gene
chr7_+_16875302 0.196 ENSMUST00000108493.1
 Dact3
dapper homolog 3, antagonist of beta-catenin (xenopus)
chr8_+_69832633 0.187 ENSMUST00000131637.2
ENSMUST00000081503.6
 Pbx4

pre B cell leukemia homeobox 4

chrX_-_8252304 0.182 ENSMUST00000115594.1
 Ftsj1
FtsJ homolog 1 (E. coli)
chr7_-_4684963 0.179 ENSMUST00000079970.4
 Hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr19_-_5610038 0.170 ENSMUST00000113641.2
 Kat5
K(lysine) acetyltransferase 5
chrX_-_8252334 0.169 ENSMUST00000115595.1
ENSMUST00000033513.3
 Ftsj1

FtsJ homolog 1 (E. coli)

chr5_-_137741102 0.168 ENSMUST00000149512.1
 Nyap1
neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1
chr7_+_18925863 0.166 ENSMUST00000172835.1
ENSMUST00000032571.8
 Nova2

neuro-oncological ventral antigen 2

chr15_-_99251929 0.164 ENSMUST00000041190.9
ENSMUST00000163506.1
 Mcrs1

microspherule protein 1

chr7_+_101663633 0.162 ENSMUST00000001884.7
 Clpb
ClpB caseinolytic peptidase B
chr16_+_17619503 0.153 ENSMUST00000165092.1
 Smpd4
sphingomyelin phosphodiesterase 4
chr4_-_116807532 0.146 ENSMUST00000106455.1
 Toe1
target of EGR1, member 1 (nuclear)
chr19_-_4811508 0.145 ENSMUST00000180008.1
ENSMUST00000113793.3
ENSMUST00000006625.7
ENSMUST00000179909.1
ENSMUST00000172000.2
 Rbm14


Gm21992

RNA binding motif protein 14


predicted gene 21992

chr17_-_56757516 0.145 ENSMUST00000044752.5
 Nrtn
neurturin
chr12_+_108334341 0.143 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr7_+_101663705 0.140 ENSMUST00000106998.1
 Clpb
ClpB caseinolytic peptidase B
chr16_+_4726357 0.138 ENSMUST00000154117.1
ENSMUST00000004172.8
 Hmox2

heme oxygenase (decycling) 2

chr7_-_27178835 0.138 ENSMUST00000093040.6
 Rab4b
RAB4B, member RAS oncogene family
chr7_-_30563184 0.135 ENSMUST00000043898.6
 Psenen
presenilin enhancer 2 homolog (C. elegans)
chr15_-_11995998 0.133 ENSMUST00000022816.8
 Sub1
SUB1 homolog (S. cerevisiae)
chr2_+_120977017 0.132 ENSMUST00000067582.7
 Tmem62
transmembrane protein 62
chr11_+_82388900 0.127 ENSMUST00000054245.4
ENSMUST00000092852.2
 Tmem132e

transmembrane protein 132E

chr8_-_36249292 0.126 ENSMUST00000065297.5
 Lonrf1
LON peptidase N-terminal domain and ring finger 1
chr4_-_116807574 0.124 ENSMUST00000030451.3
 Toe1
target of EGR1, member 1 (nuclear)
chr1_-_74600564 0.124 ENSMUST00000127938.1
ENSMUST00000154874.1
 Rnf25

ring finger protein 25

chr7_+_43444104 0.119 ENSMUST00000004729.3
 Etfb
electron transferring flavoprotein, beta polypeptide
chr5_-_137741601 0.111 ENSMUST00000119498.1
ENSMUST00000061789.7
 Nyap1

neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1

chr18_+_46597698 0.109 ENSMUST00000078079.3
ENSMUST00000168382.1
 Eif1a

eukaryotic translation initiation factor 1A

chr16_+_17619341 0.104 ENSMUST00000006053.6
ENSMUST00000171435.1
ENSMUST00000163476.1
ENSMUST00000168101.1
ENSMUST00000165363.1
ENSMUST00000169662.1
ENSMUST00000090159.4
ENSMUST00000172182.1
ENSMUST00000163592.1
 Smpd4








sphingomyelin phosphodiesterase 4








chr14_-_55591077 0.102 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
 Psme2


proteasome (prosome, macropain) activator subunit 2 (PA28 beta)


chr4_+_45018583 0.099 ENSMUST00000133157.1
ENSMUST00000029999.8
ENSMUST00000107814.3
 Polr1e


polymerase (RNA) I polypeptide E


chr7_+_25619404 0.094 ENSMUST00000077338.5
ENSMUST00000085953.3
 Atp5sl

ATP5S-like

chr7_+_30563298 0.094 ENSMUST00000043273.9
ENSMUST00000163654.1
ENSMUST00000166510.1
ENSMUST00000163482.1
ENSMUST00000166257.1
ENSMUST00000163464.1
ENSMUST00000171850.1
ENSMUST00000168931.1
 U2af1l4







U2 small nuclear RNA auxiliary factor 1-like 4







chr4_-_150008977 0.090 ENSMUST00000030830.3
 H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr17_-_35909626 0.077 ENSMUST00000141132.1
 Atat1
alpha tubulin acetyltransferase 1
chr9_+_70012540 0.075 ENSMUST00000118198.1
ENSMUST00000119905.1
ENSMUST00000119413.1
ENSMUST00000140305.1
ENSMUST00000122087.1
 Gtf2a2




general transcription factor II A, 2




chr7_+_3694512 0.073 ENSMUST00000108627.3
 Tsen34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr17_-_24455265 0.073 ENSMUST00000056032.7
 E4f1
E4F transcription factor 1
chr11_-_120824098 0.069 ENSMUST00000055655.7
 Fasn
fatty acid synthase
chr11_+_101665541 0.068 ENSMUST00000039388.2
 Arl4d
ADP-ribosylation factor-like 4D
chr18_-_37954958 0.063 ENSMUST00000043498.7
 Hdac3
histone deacetylase 3
chr7_-_100583072 0.059 ENSMUST00000152876.1
ENSMUST00000150042.1
 Mrpl48

mitochondrial ribosomal protein L48

chr11_-_119040905 0.057 ENSMUST00000026663.7
 Cbx8
chromobox 8
chr10_+_126978690 0.055 ENSMUST00000105256.2
 Ctdsp2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr11_-_76399107 0.049 ENSMUST00000021204.3
 Nxn
nucleoredoxin
chr7_+_5020376 0.045 ENSMUST00000076251.4
 Zfp865
zinc finger protein 865
chr17_-_56626872 0.041 ENSMUST00000047226.8
 Lonp1
lon peptidase 1, mitochondrial
chr8_-_71486037 0.036 ENSMUST00000093450.4
 Ano8
anoctamin 8
chr14_+_122107119 0.033 ENSMUST00000171318.1
 Tm9sf2
transmembrane 9 superfamily member 2
chr14_-_118706180 0.030 ENSMUST00000036554.6
ENSMUST00000166646.1
 Abcc4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

chr7_-_16614937 0.025 ENSMUST00000171937.1
ENSMUST00000075845.4
 Grlf1

glucocorticoid receptor DNA binding factor 1

chr18_+_12168711 0.023 ENSMUST00000025276.8
 3110002H16Rik
RIKEN cDNA 3110002H16 gene
chr17_-_35164891 0.017 ENSMUST00000025253.5
 Prrc2a
proline-rich coiled-coil 2A
chr7_-_122021143 0.012 ENSMUST00000033160.8
 Gga2
golgi associated, gamma adaptin ear containing, ARF binding protein 2
chr2_-_35200923 0.011 ENSMUST00000028238.8
ENSMUST00000113025.1
 Rab14

RAB14, member RAS oncogene family

chr7_+_5020561 0.010 ENSMUST00000085427.3
 Zfp865
zinc finger protein 865
chr14_+_122107038 0.008 ENSMUST00000026624.4
 Tm9sf2
transmembrane 9 superfamily member 2
chr2_+_32288244 0.007 ENSMUST00000113377.1
ENSMUST00000100194.2
 Golga2

golgi autoantigen, golgin subfamily a, 2

chr2_-_24935148 0.006 ENSMUST00000102935.3
ENSMUST00000133934.1
ENSMUST00000028349.7
 Arrdc1


arrestin domain containing 1


chr17_+_35059035 0.004 ENSMUST00000007255.6
ENSMUST00000174493.1
 Ddah2

dimethylarginine dimethylaminohydrolase 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:1900133 renin secretion into blood stream(GO:0002001) regulation of renin secretion into blood stream(GO:1900133)
0.1 0.3 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
0.1 0.7 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.1 0.3 GO:0009826 unidimensional cell growth(GO:0009826)
0.1 0.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 0.3 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.3 GO:0010957 negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.4 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.1 0.4 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.6 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.4 GO:0042167 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.3 GO:0090166 Golgi disassembly(GO:0090166)
0.0 0.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.0 0.2 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.0 0.3 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.4 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.7 GO:0030903 notochord development(GO:0030903)
0.0 0.3 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.1 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.2 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 1.1 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.8 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 0.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.1 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.1 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.3 GO:0099524 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.1 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.4 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 1.2 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.1 GO:0089701 U2AF(GO:0089701)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0051379 epinephrine binding(GO:0051379)
0.2 0.7 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.1 0.8 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 0.4 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.6 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.4 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.2 GO:0004074 biliverdin reductase activity(GO:0004074)
0.0 0.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.1 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.3 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.2 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.1 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.1 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.0 GO:0004176 ATP-dependent peptidase activity(GO:0004176)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 0.8 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins