Motif ID: Klf15

Z-value: 0.783


Transcription factors associated with Klf15:

Gene SymbolEntrez IDGene Name
Klf15 ENSMUSG00000030087.5 Klf15

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf15mm10_v2_chr6_+_90462562_904625870.717.6e-07Click!


Activity profile for motif Klf15.

activity profile for motif Klf15


Sorted Z-values histogram for motif Klf15

Sorted Z-values for motif Klf15



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf15

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56971762 7.378 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr18_-_89769479 4.458 ENSMUST00000097495.3
 Dok6
docking protein 6
chr18_-_66291770 4.375 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1
chr1_-_56972437 4.077 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr5_+_130448801 3.319 ENSMUST00000111288.2
 Caln1
calneuron 1
chr3_+_117575268 3.208 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr5_+_137288273 3.177 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr11_+_50602072 3.135 ENSMUST00000040523.8
 Adamts2
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
chr6_-_148444336 3.034 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr4_+_129985098 2.798 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr10_-_54075730 2.765 ENSMUST00000105469.1
ENSMUST00000003843.8
 Man1a

mannosidase 1, alpha

chr17_+_46297917 2.657 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr10_-_127666598 2.489 ENSMUST00000099157.3
 Nab2
Ngfi-A binding protein 2
chr11_-_54068932 2.466 ENSMUST00000093109.4
ENSMUST00000018755.3
 Pdlim4

PDZ and LIM domain 4

chr3_+_118433797 2.370 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr12_+_81631369 2.201 ENSMUST00000036116.5
 Ttc9
tetratricopeptide repeat domain 9
chrX_-_136868537 2.179 ENSMUST00000058814.6
 Rab9b
RAB9B, member RAS oncogene family
chr10_-_127666673 2.153 ENSMUST00000026469.2
 Nab2
Ngfi-A binding protein 2
chr10_-_54075702 2.129 ENSMUST00000105470.1
 Man1a
mannosidase 1, alpha
chr2_-_5714490 2.109 ENSMUST00000044009.7
 Camk1d
calcium/calmodulin-dependent protein kinase ID

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 11.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 5.0 GO:0006491 N-glycan processing(GO:0006491)
0.7 4.6 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.2 4.6 GO:0030325 adrenal gland development(GO:0030325)
1.1 4.4 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.7 4.0 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.5 3.2 GO:0019695 choline metabolic process(GO:0019695)
0.2 3.1 GO:0030574 collagen catabolic process(GO:0030574)
0.7 3.0 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 3.0 GO:0006396 RNA processing(GO:0006396)
0.1 2.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 2.5 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 2.3 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 2.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.3 2.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.4 2.0 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.5 1.9 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.1 1.9 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 1.9 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
0.6 1.8 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 6.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 5.6 GO:0005581 collagen trimer(GO:0005581)
0.1 4.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 3.5 GO:0001650 fibrillar center(GO:0001650)
0.0 3.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
1.1 3.3 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 3.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 3.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 2.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.5 GO:0030175 filopodium(GO:0030175)
0.0 2.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 2.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.7 2.0 GO:0098855 HCN channel complex(GO:0098855)
0.1 1.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 1.7 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 1.7 GO:0005795 Golgi stack(GO:0005795)
0.1 1.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 1.5 GO:0008091 spectrin(GO:0008091)
0.1 1.5 GO:0005885 Arp2/3 protein complex(GO:0005885)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0070412 R-SMAD binding(GO:0070412)
0.5 4.9 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 4.5 GO:0005158 insulin receptor binding(GO:0005158)
0.1 4.4 GO:0005518 collagen binding(GO:0005518)
0.2 3.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.8 3.2 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.0 2.9 GO:0019213 deacetylase activity(GO:0019213)
0.0 2.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.2 GO:0019003 GDP binding(GO:0019003)
0.0 2.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 2.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 2.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 2.0 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 2.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 1.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.9 GO:0005109 frizzled binding(GO:0005109)
0.2 1.7 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 1.6 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 1.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.3 1.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 4.2 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 4.1 NABA_COLLAGENS Genes encoding collagen proteins
0.1 4.1 PID_CDC42_PATHWAY CDC42 signaling events
0.0 4.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 3.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.0 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 2.4 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 2.4 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 2.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 2.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 1.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 1.8 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.2 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.2 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 1.1 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 3.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 3.2 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 3.2 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 2.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 1.7 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.6 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.2 1.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 1.3 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 1.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 1.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.1 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.1 0.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere