Motif ID: Klf16_Sp8
Z-value: 1.075
Transcription factors associated with Klf16_Sp8:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Klf16 | ENSMUSG00000035397.8 | Klf16 |
| Sp8 | ENSMUSG00000048562.6 | Sp8 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sp8 | mm10_v2_chr12_+_118846329_118846329 | 0.79 | 8.3e-09 | Click! |
| Klf16 | mm10_v2_chr10_-_80577285_80577327 | -0.60 | 9.6e-05 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,090 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 28.7 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.4 | 17.8 | GO:0051310 | metaphase plate congression(GO:0051310) |
| 0.2 | 17.7 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.8 | 16.4 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 1.1 | 16.1 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 1.9 | 14.8 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.5 | 14.2 | GO:0034508 | centromere complex assembly(GO:0034508) |
| 3.4 | 13.7 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 1.1 | 12.8 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 2.8 | 11.4 | GO:0003360 | brainstem development(GO:0003360) |
| 2.3 | 11.3 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 1.0 | 10.2 | GO:2000781 | positive regulation of double-strand break repair(GO:2000781) |
| 0.8 | 10.2 | GO:0048368 | lateral mesoderm development(GO:0048368) |
| 0.4 | 10.2 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 3.3 | 9.9 | GO:0030421 | defecation(GO:0030421) |
| 0.5 | 9.7 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.4 | 9.7 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) |
| 0.3 | 9.6 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.9 | 9.2 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.5 | 8.9 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 355 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 74.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 50.6 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.0 | 46.1 | GO:0005634 | nucleus(GO:0005634) |
| 0.1 | 31.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.8 | 17.6 | GO:0000796 | condensin complex(GO:0000796) |
| 0.8 | 16.4 | GO:0010369 | chromocenter(GO:0010369) |
| 0.2 | 16.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.3 | 14.8 | GO:0005844 | polysome(GO:0005844) |
| 0.2 | 14.0 | GO:0016459 | myosin complex(GO:0016459) |
| 2.7 | 13.7 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.2 | 13.7 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 13.3 | GO:0005657 | replication fork(GO:0005657) |
| 0.7 | 13.0 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 12.5 | GO:0000785 | chromatin(GO:0000785) |
| 0.3 | 12.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 3.8 | 11.4 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.5 | 10.4 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.2 | 10.0 | GO:0005902 | microvillus(GO:0005902) |
| 0.9 | 9.7 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 3.1 | 9.4 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 550 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 42.9 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.2 | 34.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 32.7 | GO:0003677 | DNA binding(GO:0003677) |
| 0.3 | 31.4 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.2 | 27.8 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 27.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 26.5 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.6 | 23.0 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.5 | 22.0 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.2 | 18.7 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 1.2 | 17.2 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.2 | 17.0 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.4 | 15.2 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 14.9 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.2 | 14.6 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.8 | 14.3 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.6 | 13.8 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.5 | 12.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.2 | 11.9 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 1.0 | 11.4 | GO:0019992 | diacylglycerol binding(GO:0019992) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 105 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 46.8 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.6 | 32.7 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 1.7 | 23.4 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.3 | 22.1 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.3 | 19.8 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.3 | 17.2 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.4 | 16.0 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.3 | 13.6 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 12.9 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 11.7 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.5 | 9.8 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.2 | 9.5 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.3 | 8.6 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.3 | 8.3 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.2 | 7.8 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 6.9 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.2 | 6.8 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 6.6 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 6.4 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.2 | 6.1 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 140 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 36.2 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.6 | 31.3 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.4 | 30.5 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.7 | 20.3 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.6 | 19.7 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.9 | 18.8 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.6 | 16.9 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.4 | 10.7 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.4 | 10.5 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.6 | 10.4 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.7 | 9.8 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.5 | 9.8 | REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.6 | 9.6 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.4 | 8.3 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.1 | 7.9 | REACTOME_GLUCOSE_METABOLISM | Genes involved in Glucose metabolism |
| 0.4 | 7.6 | REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY | Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| 0.4 | 7.4 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.6 | 7.2 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.3 | 7.0 | REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.2 | 7.0 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
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