Motif ID: Klf3

Z-value: 0.255


Transcription factors associated with Klf3:

Gene SymbolEntrez IDGene Name
Klf3 ENSMUSG00000029178.8 Klf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf3mm10_v2_chr5_+_64803513_64803530-0.521.1e-03Click!


Activity profile for motif Klf3.

activity profile for motif Klf3


Sorted Z-values histogram for motif Klf3

Sorted Z-values for motif Klf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_72824482 0.516 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr1_+_107511489 0.508 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr12_+_87026286 0.504 ENSMUST00000146292.1
 Tmem63c
transmembrane protein 63c
chr12_+_87026564 0.498 ENSMUST00000110187.1
ENSMUST00000156162.1
 Tmem63c

transmembrane protein 63c

chr1_+_107511416 0.475 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr19_+_10041548 0.291 ENSMUST00000115995.2
 Fads3
fatty acid desaturase 3
chr7_+_82337218 0.274 ENSMUST00000173828.1
 Adamtsl3
ADAMTS-like 3
chr3_+_135438722 0.245 ENSMUST00000166033.1
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr3_+_90080442 0.210 ENSMUST00000127955.1
 Tpm3
tropomyosin 3, gamma
chrX_-_102252154 0.208 ENSMUST00000050551.3
 Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr13_-_74292297 0.192 ENSMUST00000109640.1
ENSMUST00000022059.7
 Ahrr

aryl-hydrocarbon receptor repressor

chr3_+_90079540 0.176 ENSMUST00000029549.9
ENSMUST00000118566.1
ENSMUST00000119158.1
 Tpm3


tropomyosin 3, gamma


chr7_-_4149781 0.164 ENSMUST00000058358.6
 Leng9
leukocyte receptor cluster (LRC) member 9
chr11_+_68968107 0.156 ENSMUST00000102606.3
ENSMUST00000018884.5
 Slc25a35

solute carrier family 25, member 35

chr11_-_97500340 0.144 ENSMUST00000056955.1
 4933428G20Rik
RIKEN cDNA 4933428G20 gene
chr3_-_89089955 0.134 ENSMUST00000166687.1
 Rusc1
RUN and SH3 domain containing 1
chr9_-_95815389 0.123 ENSMUST00000119760.1
 Pls1
plastin 1 (I-isoform)
chr9_-_67539392 0.116 ENSMUST00000039662.8
 Tln2
talin 2
chr1_+_131867224 0.097 ENSMUST00000112386.1
ENSMUST00000027693.7
 Rab7l1

RAB7, member RAS oncogene family-like 1

chrX_+_7884321 0.091 ENSMUST00000096514.3
ENSMUST00000123277.1
 Slc35a2

solute carrier family 35 (UDP-galactose transporter), member A2

chr1_+_86064619 0.049 ENSMUST00000027432.8
 Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr5_+_124541296 0.044 ENSMUST00000124529.1
 Tmed2
transmembrane emp24 domain trafficking protein 2
chrX_-_102251852 0.040 ENSMUST00000101336.3
ENSMUST00000136277.1
 Cited1

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

chr1_+_135147615 0.033 ENSMUST00000125774.1
 Arl8a
ADP-ribosylation factor-like 8A
chrX_-_74246534 0.023 ENSMUST00000101454.2
ENSMUST00000033699.6
 Flna

filamin, alpha

chr7_-_103827922 0.020 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr3_+_89266552 0.008 ENSMUST00000040824.1
 Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr19_-_53390559 0.005 ENSMUST00000025997.5
 Smndc1
survival motor neuron domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.0 0.5 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.0 0.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.0 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 1.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.4 GO:0008307 structural constituent of muscle(GO:0008307)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha