Motif ID: Klf4_Sp3

Z-value: 1.273

Transcription factors associated with Klf4_Sp3:

Gene SymbolEntrez IDGene Name
Klf4 ENSMUSG00000003032.8 Klf4
Sp3 ENSMUSG00000027109.10 Sp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf4mm10_v2_chr4_-_55532453_55532485-0.096.0e-01Click!
Sp3mm10_v2_chr2_-_72980402_72980471-0.038.4e-01Click!


Activity profile for motif Klf4_Sp3.

activity profile for motif Klf4_Sp3


Sorted Z-values histogram for motif Klf4_Sp3

Sorted Z-values for motif Klf4_Sp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf4_Sp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_87473116 14.684 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr10_-_127534540 13.606 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr7_+_29289300 11.443 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr8_+_87472805 8.230 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
 Gm2694


predicted gene 2694


chr8_+_87472838 8.204 ENSMUST00000180806.2
 Gm2694
predicted gene 2694
chr3_-_8667033 7.684 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr5_-_113908685 7.341 ENSMUST00000004646.6
 Coro1c
coronin, actin binding protein 1C
chr4_-_117133953 7.174 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr7_-_34812677 7.128 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr8_-_87472576 6.960 ENSMUST00000034076.8
 Cbln1
cerebellin 1 precursor protein
chr8_-_87472365 6.782 ENSMUST00000169693.1
 Cbln1
cerebellin 1 precursor protein
chr6_-_72958097 6.776 ENSMUST00000114049.1
 Tmsb10
thymosin, beta 10
chr11_-_95587691 6.758 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr1_-_175692624 6.718 ENSMUST00000027809.7
 Opn3
opsin 3
chr6_-_115994953 6.657 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr8_+_105518736 6.652 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr7_-_31051431 6.424 ENSMUST00000073892.4
 Fxyd7
FXYD domain-containing ion transport regulator 7
chr11_-_76399107 6.005 ENSMUST00000021204.3
 Nxn
nucleoredoxin
chr1_-_172057573 5.990 ENSMUST00000059794.3
 Nhlh1
nescient helix loop helix 1
chr7_+_45163915 5.885 ENSMUST00000085374.5
 Slc17a7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,089 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.8 GO:0035690 cellular response to drug(GO:0035690)
1.1 14.7 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.4 11.7 GO:0051310 metaphase plate congression(GO:0051310)
1.6 11.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.7 10.9 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
1.2 10.4 GO:1990845 adaptive thermogenesis(GO:1990845)
0.5 10.4 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
1.1 10.3 GO:0001842 neural fold formation(GO:0001842)
0.3 10.1 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.6 9.9 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.2 9.8 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 9.6 GO:0006284 base-excision repair(GO:0006284)
0.3 9.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
1.3 9.2 GO:0008343 adult feeding behavior(GO:0008343)
0.8 9.2 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.8 9.0 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 8.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.4 8.6 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.5 8.3 GO:0006337 nucleosome disassembly(GO:0006337)
2.7 8.2 GO:0018298 protein-chromophore linkage(GO:0018298)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 419 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.5 GO:0016607 nuclear speck(GO:0016607)
0.2 16.4 GO:0000776 kinetochore(GO:0000776)
0.4 16.0 GO:0002102 podosome(GO:0002102)
0.1 15.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.3 15.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.8 13.9 GO:1904115 axon cytoplasm(GO:1904115)
0.5 12.7 GO:0071565 nBAF complex(GO:0071565)
0.1 11.0 GO:0030496 midbody(GO:0030496)
0.6 10.0 GO:0043196 varicosity(GO:0043196)
0.2 9.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.3 8.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 7.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.9 7.8 GO:0005883 neurofilament(GO:0005883)
0.5 7.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.5 7.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 7.1 GO:0097470 ribbon synapse(GO:0097470)
0.4 7.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 7.0 GO:0000791 euchromatin(GO:0000791)
2.3 6.9 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.5 6.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 578 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 21.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 17.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 15.9 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.3 13.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 13.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 13.1 GO:0003785 actin monomer binding(GO:0003785)
0.1 12.6 GO:0003924 GTPase activity(GO:0003924)
0.2 12.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 12.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
2.3 11.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.5 11.5 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.7 10.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.7 9.7 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.7 9.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 9.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.2 8.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.4 8.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
1.1 8.7 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
2.1 8.4 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 30.4 PID_PLK1_PATHWAY PLK1 signaling events
0.3 28.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 21.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.4 17.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.5 17.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 14.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.9 12.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 12.5 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2 12.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.3 10.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 10.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.5 9.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4 9.7 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 9.7 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.3 8.6 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 7.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 7.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 6.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 6.4 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.2 6.1 PID_FGF_PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.8 REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.3 26.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 25.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 17.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 15.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.4 15.1 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.7 14.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.5 14.2 REACTOME_KINESINS Genes involved in Kinesins
0.5 12.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 12.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 12.0 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 11.9 REACTOME_REGULATION_OF_APOPTOSIS Genes involved in Regulation of Apoptosis
0.5 11.8 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.3 11.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 11.7 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.5 10.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.5 10.2 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.3 10.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.4 9.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.4 8.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity