Motif ID: Klf6_Patz1

Z-value: 0.865

Transcription factors associated with Klf6_Patz1:

Gene SymbolEntrez IDGene Name
Klf6 ENSMUSG00000000078.6 Klf6
Patz1 ENSMUSG00000020453.11 Patz1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf6mm10_v2_chr13_+_5861489_58615010.325.0e-02Click!
Patz1mm10_v2_chr11_+_3289880_32899930.231.8e-01Click!


Activity profile for motif Klf6_Patz1.

activity profile for motif Klf6_Patz1


Sorted Z-values histogram for motif Klf6_Patz1

Sorted Z-values for motif Klf6_Patz1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf6_Patz1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_125490688 4.565 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr7_+_36698002 3.639 ENSMUST00000021641.6
 Tshz3
teashirt zinc finger family member 3
chr11_+_119942763 3.397 ENSMUST00000026436.3
ENSMUST00000106231.1
ENSMUST00000075180.5
ENSMUST00000103021.3
ENSMUST00000106233.1
 Baiap2




brain-specific angiogenesis inhibitor 1-associated protein 2




chr11_-_95514570 3.254 ENSMUST00000058866.7
 Nxph3
neurexophilin 3
chr11_-_95587691 3.165 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr7_+_44310213 3.116 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr5_-_89883321 2.986 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr14_-_39472825 2.670 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr15_-_60824942 2.576 ENSMUST00000100635.3
 Fam84b
family with sequence similarity 84, member B
chr9_+_47530173 2.421 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
 Cadm1





cell adhesion molecule 1





chr3_+_121953213 2.389 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr7_-_34812677 2.369 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr11_+_67455339 2.308 ENSMUST00000108681.1
 Gas7
growth arrest specific 7
chr17_+_28142267 2.283 ENSMUST00000043503.3
 Scube3
signal peptide, CUB domain, EGF-like 3
chr10_+_85386813 2.109 ENSMUST00000105307.1
ENSMUST00000020231.3
 Btbd11

BTB (POZ) domain containing 11

chr17_+_26941420 2.017 ENSMUST00000081285.3
ENSMUST00000177932.1
 Syngap1

synaptic Ras GTPase activating protein 1 homolog (rat)

chr5_+_37028329 1.987 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr7_+_123982799 1.979 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr4_-_68954351 1.964 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr6_-_119848093 1.960 ENSMUST00000079582.4
 Erc1
ELKS/RAB6-interacting/CAST family member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 645 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.3 GO:0071625 vocalization behavior(GO:0071625)
0.4 7.1 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.5 5.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
1.7 5.0 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.2 4.7 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 4.1 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.4 3.9 GO:0046959 habituation(GO:0046959)
1.2 3.7 GO:0072194 kidney smooth muscle tissue development(GO:0072194)
0.7 3.7 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.9 3.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.8 3.2 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 3.2 GO:0051764 actin crosslink formation(GO:0051764)
0.9 2.7 GO:0009826 unidimensional cell growth(GO:0009826)
0.3 2.7 GO:0035608 protein deglutamylation(GO:0035608)
0.2 2.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 2.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.4 2.6 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.4 2.6 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.4 2.6 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 2.6 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 228 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 8.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 6.2 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 5.8 GO:0030118 clathrin coat(GO:0030118)
0.2 5.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 5.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 5.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 4.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.4 4.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 4.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 3.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 3.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.7 GO:0030496 midbody(GO:0030496)
0.1 3.6 GO:0043198 dendritic shaft(GO:0043198)
0.1 3.5 GO:0043034 costamere(GO:0043034)
0.1 3.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 3.3 GO:0071565 nBAF complex(GO:0071565)
0.1 3.3 GO:0030673 axolemma(GO:0030673)
0.2 3.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 3.0 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 369 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 7.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 6.7 GO:0001786 phosphatidylserine binding(GO:0001786)
1.0 5.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.3 5.2 GO:0045499 chemorepellent activity(GO:0045499)
0.2 4.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.5 4.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.4 3.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.3 3.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.9 3.7 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.3 3.3 GO:0048406 nerve growth factor binding(GO:0048406)
1.1 3.2 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.4 3.2 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 3.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.9 GO:0048365 Rac GTPase binding(GO:0048365)
0.9 2.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 2.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 2.5 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 2.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 4.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 4.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 3.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.7 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2 2.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 2.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.4 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 2.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 2.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 1.7 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.5 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.5 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.3 PID_CDC42_PATHWAY CDC42 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 6.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 5.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 4.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 3.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 2.9 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 2.4 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 2.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 2.2 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.0 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 2.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 1.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.9 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling
0.1 1.8 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.8 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 1.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription