Motif ID: Klf7

Z-value: 0.435


Transcription factors associated with Klf7:

Gene SymbolEntrez IDGene Name
Klf7 ENSMUSG00000025959.7 Klf7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf7mm10_v2_chr1_-_64122256_64122321-0.473.6e-03Click!


Activity profile for motif Klf7.

activity profile for motif Klf7


Sorted Z-values histogram for motif Klf7

Sorted Z-values for motif Klf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 3.055 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr1_-_138847579 1.839 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr2_+_172550991 1.265 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr2_+_119047116 1.234 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr15_+_99074968 1.127 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr2_+_119047129 1.027 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr5_+_33658123 0.867 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr12_-_4592927 0.756 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr9_-_32344237 0.749 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr5_+_140607334 0.628 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr2_-_151973387 0.620 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr5_+_137761680 0.604 ENSMUST00000110983.2
ENSMUST00000031738.4
 Tsc22d4

TSC22 domain family, member 4

chr2_+_158375638 0.564 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr10_+_79682169 0.504 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr13_+_21722057 0.490 ENSMUST00000110476.3
 Hist1h2bm
histone cluster 1, H2bm
chr18_+_35118880 0.428 ENSMUST00000042345.6
 Ctnna1
catenin (cadherin associated protein), alpha 1
chr11_-_40733373 0.411 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr12_+_118846329 0.398 ENSMUST00000063918.2
 Sp8
trans-acting transcription factor 8
chr5_+_137778849 0.371 ENSMUST00000126126.1
ENSMUST00000031739.4
 Ppp1r35

protein phosphatase 1, regulatory subunit 35

chr4_-_87230435 0.365 ENSMUST00000107157.2
 Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr5_-_136135989 0.353 ENSMUST00000150406.1
ENSMUST00000006301.4
 Lrwd1

leucine-rich repeats and WD repeat domain containing 1

chr11_-_70654624 0.352 ENSMUST00000018437.2
 Pfn1
profilin 1
chrX_+_136270253 0.340 ENSMUST00000178632.1
ENSMUST00000053540.4
 Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr8_+_70152754 0.309 ENSMUST00000072500.6
ENSMUST00000164040.1
ENSMUST00000110146.2
ENSMUST00000110143.1
ENSMUST00000110141.2
ENSMUST00000110140.1
 2310045N01Rik

Mef2b



RIKEN cDNA 2310045N01 gene

myocyte enhancer factor 2B



chr5_+_136136202 0.291 ENSMUST00000143229.1
 Alkbh4
alkB, alkylation repair homolog 4 (E. coli)
chr1_-_120121030 0.279 ENSMUST00000027634.6
 Dbi
diazepam binding inhibitor
chr8_+_105860634 0.275 ENSMUST00000008594.7
 Nutf2
nuclear transport factor 2
chr1_+_167689108 0.271 ENSMUST00000111377.1
 Lmx1a
LIM homeobox transcription factor 1 alpha
chr7_-_45154519 0.267 ENSMUST00000007977.7
ENSMUST00000107815.1
 Aldh16a1

aldehyde dehydrogenase 16 family, member A1

chr5_+_136136137 0.247 ENSMUST00000136634.1
ENSMUST00000041100.3
 Alkbh4

alkB, alkylation repair homolog 4 (E. coli)

chr7_-_132776855 0.236 ENSMUST00000106168.1
 Fam53b
family with sequence similarity 53, member B
chr2_+_156312589 0.228 ENSMUST00000073942.5
ENSMUST00000109580.1
 Cnbd2

cyclic nucleotide binding domain containing 2

chr1_-_120120937 0.226 ENSMUST00000151708.1
 Dbi
diazepam binding inhibitor
chr9_-_71485893 0.213 ENSMUST00000034720.5
 Polr2m
polymerase (RNA) II (DNA directed) polypeptide M
chr1_-_23383149 0.207 ENSMUST00000027343.5
 Ogfrl1
opioid growth factor receptor-like 1
chr11_+_40733639 0.197 ENSMUST00000020578.4
 Nudcd2
NudC domain containing 2
chr8_+_84901928 0.193 ENSMUST00000067060.7
 Klf1
Kruppel-like factor 1 (erythroid)
chr11_+_80383279 0.179 ENSMUST00000165565.1
ENSMUST00000017567.7
 Zfp207

zinc finger protein 207

chr7_+_58658181 0.178 ENSMUST00000168747.1
 Atp10a
ATPase, class V, type 10A
chr2_+_34772089 0.172 ENSMUST00000028222.6
ENSMUST00000100171.2
 Hspa5

heat shock protein 5

chr4_+_63558748 0.165 ENSMUST00000077709.4
 6330416G13Rik
RIKEN cDNA 6330416G13 gene
chr10_+_86705811 0.162 ENSMUST00000061458.7
ENSMUST00000075632.6
 BC030307

cDNA sequence BC030307

chr11_+_78176711 0.159 ENSMUST00000098545.5
 Tlcd1
TLC domain containing 1
chr11_-_89639631 0.147 ENSMUST00000128717.1
 Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr2_-_156312470 0.145 ENSMUST00000079125.6
 Scand1
SCAN domain-containing 1
chr3_+_106721893 0.139 ENSMUST00000106736.2
ENSMUST00000154973.1
ENSMUST00000131330.1
ENSMUST00000150513.1
 Lrif1



ligand dependent nuclear receptor interacting factor 1



chr9_-_45936049 0.127 ENSMUST00000034590.2
 Tagln
transgelin
chr8_-_84966008 0.123 ENSMUST00000109738.3
ENSMUST00000065049.8
ENSMUST00000128972.1
 Rnaseh2a


ribonuclease H2, large subunit


chr6_-_88874597 0.121 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
 Podxl2


podocalyxin-like 2


chr7_-_127993831 0.110 ENSMUST00000033056.3
 Pycard
PYD and CARD domain containing
chr6_-_88875035 0.097 ENSMUST00000145944.1
 Podxl2
podocalyxin-like 2
chr7_+_28350652 0.091 ENSMUST00000082134.4
 Rps16
ribosomal protein S16
chr17_+_26113286 0.088 ENSMUST00000025010.7
 Tmem8
transmembrane protein 8 (five membrane-spanning domains)
chr3_+_51224447 0.085 ENSMUST00000023849.8
ENSMUST00000167780.1
 Ccrn4l

CCR4 carbon catabolite repression 4-like (S. cerevisiae)

chr7_-_101011976 0.081 ENSMUST00000178340.1
ENSMUST00000037540.3
 P2ry2

purinergic receptor P2Y, G-protein coupled 2

chr5_+_45520221 0.078 ENSMUST00000156481.1
ENSMUST00000119579.1
ENSMUST00000118833.1
 Med28


mediator of RNA polymerase II transcription, subunit 28 homolog (yeast)


chr7_-_19404082 0.077 ENSMUST00000108458.3
 Klc3
kinesin light chain 3
chr16_-_91931643 0.077 ENSMUST00000023677.3
 Atp5o
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr7_+_126976338 0.073 ENSMUST00000032920.3
 Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr11_+_72301613 0.072 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1


chr1_-_172082757 0.072 ENSMUST00000003550.4
 Ncstn
nicastrin
chr2_-_156180135 0.068 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr11_-_120991039 0.061 ENSMUST00000070575.7
 Csnk1d
casein kinase 1, delta
chr6_+_52713729 0.060 ENSMUST00000080723.4
ENSMUST00000149588.1
 Tax1bp1

Tax1 (human T cell leukemia virus type I) binding protein 1

chr2_+_32775769 0.056 ENSMUST00000066352.5
 Ptrh1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr7_+_45154297 0.048 ENSMUST00000107813.1
ENSMUST00000125953.1
ENSMUST00000085375.5
ENSMUST00000144597.1
 Pih1d1



PIH1 domain containing 1



chr11_-_101302206 0.048 ENSMUST00000140706.1
ENSMUST00000170502.1
ENSMUST00000172233.1
ENSMUST00000130916.1
 Becn1



beclin 1, autophagy related



chr4_-_132329414 0.046 ENSMUST00000127402.1
ENSMUST00000105962.3
ENSMUST00000030730.7
ENSMUST00000105960.1
 Trnau1ap



tRNA selenocysteine 1 associated protein 1



chr12_+_49383007 0.041 ENSMUST00000021333.3
 Foxg1
forkhead box G1
chr19_+_5637475 0.041 ENSMUST00000025867.5
 Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr1_+_57406328 0.036 ENSMUST00000027114.5
 9430016H08Rik
RIKEN cDNA 9430016H08 gene
chr3_+_106721672 0.036 ENSMUST00000098750.2
ENSMUST00000130105.1
 Lrif1

ligand dependent nuclear receptor interacting factor 1

chr16_-_56717286 0.033 ENSMUST00000121554.1
ENSMUST00000128551.1
 Tfg

Trk-fused gene

chr11_+_78536355 0.027 ENSMUST00000128788.1
 Ift20
intraflagellar transport 20
chr7_+_45154644 0.024 ENSMUST00000153973.1
 Pih1d1
PIH1 domain containing 1
chr7_-_141414115 0.023 ENSMUST00000106008.1
 Pddc1
Parkinson disease 7 domain containing 1
chr11_-_78536235 0.022 ENSMUST00000017759.2
ENSMUST00000108277.2
 Tnfaip1

tumor necrosis factor, alpha-induced protein 1 (endothelial)

chr7_-_116198487 0.020 ENSMUST00000181981.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr8_+_3500451 0.015 ENSMUST00000004683.6
ENSMUST00000160338.1
 Mcoln1

mucolipin 1

chr12_+_49382791 0.014 ENSMUST00000179669.1
 Foxg1
forkhead box G1
chr5_-_134456702 0.012 ENSMUST00000073161.5
ENSMUST00000171794.2
ENSMUST00000111245.2
ENSMUST00000100654.3
ENSMUST00000167084.2
ENSMUST00000100652.3
ENSMUST00000100650.3
ENSMUST00000074114.5
 Gtf2ird1







general transcription factor II I repeat domain-containing 1








Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.4 1.3 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.4 1.8 GO:0035262 gonad morphogenesis(GO:0035262)
0.2 0.5 GO:0036090 cleavage furrow ingression(GO:0036090)
0.1 0.7 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 0.6 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.4 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.5 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.1 0.3 GO:0090204 protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046)
0.1 0.6 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.4 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.1 0.2 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 0.2 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.1 0.9 GO:0030953 astral microtubule organization(GO:0030953)
0.1 0.4 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.1 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.0 0.1 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.3 GO:0042048 olfactory behavior(GO:0042048)
0.0 0.1 GO:0021852 pyramidal neuron migration(GO:0021852)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)
0.0 0.0 GO:0071224 cellular response to peptidoglycan(GO:0071224)
0.0 0.1 GO:0060406 positive regulation of penile erection(GO:0060406)
0.0 0.2 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 0.1 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.4 GO:0009954 proximal/distal pattern formation(GO:0009954)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990047 spindle matrix(GO:1990047)
0.1 0.4 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.4 GO:0005915 zonula adherens(GO:0005915)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.5 GO:0070938 contractile ring(GO:0070938)
0.0 0.1 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.0 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.1 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.2 0.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 0.5 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 0.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.4 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 1.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 1.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.4 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.6 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.1 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions