Motif ID: Klf8

Z-value: 0.491


Transcription factors associated with Klf8:

Gene SymbolEntrez IDGene Name
Klf8 ENSMUSG00000041649.7 Klf8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf8mm10_v2_chrX_+_153237748_153237748-0.153.7e-01Click!


Activity profile for motif Klf8.

activity profile for motif Klf8


Sorted Z-values histogram for motif Klf8

Sorted Z-values for motif Klf8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_142657466 1.015 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr6_+_114131229 0.882 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr2_-_36105271 0.812 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr19_+_5740885 0.808 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr11_-_32222233 0.774 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr12_+_84009481 0.756 ENSMUST00000168120.1
 Acot1
acyl-CoA thioesterase 1
chr7_-_31054815 0.728 ENSMUST00000071697.4
ENSMUST00000108110.3
 Fxyd1

FXYD domain-containing ion transport regulator 1

chr6_+_5725639 0.708 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr11_-_116654245 0.689 ENSMUST00000021166.5
 Cygb
cytoglobin
chr1_-_184883218 0.676 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr1_-_33907721 0.638 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr19_+_8664005 0.632 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr2_-_165473187 0.622 ENSMUST00000029208.8
ENSMUST00000109279.2
 Slc13a3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr7_-_31055594 0.621 ENSMUST00000039909.6
 Fxyd1
FXYD domain-containing ion transport regulator 1
chr1_+_172499948 0.581 ENSMUST00000111230.1
 Tagln2
transgelin 2
chr16_+_30599717 0.564 ENSMUST00000059078.3
 Fam43a
family with sequence similarity 43, member A
chr5_-_123132651 0.556 ENSMUST00000031401.5
 Rhof
ras homolog gene family, member f
chr2_-_168741898 0.545 ENSMUST00000109176.1
ENSMUST00000178504.1
 Atp9a

ATPase, class II, type 9A

chr18_-_78206408 0.538 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr14_-_103843685 0.532 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.3 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) regulation of inorganic anion transmembrane transport(GO:1903795)
0.1 1.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 1.0 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.0 0.9 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.3 0.8 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.3 0.8 GO:0036166 phenotypic switching(GO:0036166)
0.2 0.8 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.1 0.8 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 0.7 GO:0015671 oxygen transport(GO:0015671)
0.1 0.7 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.1 0.7 GO:0019346 homoserine metabolic process(GO:0009092) transsulfuration(GO:0019346)
0.1 0.7 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 0.6 GO:0015744 succinate transport(GO:0015744)
0.1 0.6 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.6 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.2 0.5 GO:0071918 urea transmembrane transport(GO:0071918)
0.2 0.5 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.1 0.5 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 0.8 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2 0.8 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.2 0.7 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.1 0.7 GO:0031415 NatA complex(GO:0031415)
0.0 0.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.6 GO:0032279 asymmetric synapse(GO:0032279)
0.2 0.5 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.4 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.4 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.0 0.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.3 GO:0045160 myosin I complex(GO:0045160)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.3 GO:1902737 dendritic filopodium(GO:1902737)
0.1 0.3 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.3 GO:0008091 spectrin(GO:0008091)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 0.9 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.9 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.9 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 0.8 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.8 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.8 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 0.7 GO:0004096 catalase activity(GO:0004096)
0.1 0.7 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.1 0.7 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 0.6 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.1 0.6 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 0.5 GO:0004962 endothelin receptor activity(GO:0004962)
0.2 0.5 GO:0005118 sevenless binding(GO:0005118)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.8 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.1 PID_RAC1_PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.9 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.9 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 0.6 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 0.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 0.5 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.5 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.4 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.2 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.1 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.1 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters