Motif ID: Lef1

Z-value: 1.717


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131110350_1311104710.581.6e-04Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_98169542 11.455 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_+_70474923 11.437 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr10_-_92165159 10.211 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr7_-_37772868 10.064 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr7_-_115824699 9.262 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr18_-_62756275 8.800 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr19_+_55742242 7.868 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr7_-_37773555 7.287 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr3_+_102010138 6.778 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr2_+_116067213 6.573 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr4_+_8691303 6.335 ENSMUST00000051558.3
 Chd7
chromodomain helicase DNA binding protein 7
chr5_-_28210022 6.264 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr4_-_91376490 6.122 ENSMUST00000107124.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr2_-_116067391 6.091 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr4_-_91376433 6.062 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr1_-_165934900 5.978 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
 Pou2f1


POU domain, class 2, transcription factor 1


chr7_-_116038734 5.809 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr1_-_186705980 5.716 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr4_-_24430838 5.504 ENSMUST00000183964.1
 RP23-35K5.2
RP23-35K5.2
chr7_-_37769624 5.374 ENSMUST00000175941.1
 Zfp536
zinc finger protein 536

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 166 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 28.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.6 20.7 GO:0048625 myoblast fate commitment(GO:0048625)
1.4 15.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.5 12.5 GO:0036342 post-anal tail morphogenesis(GO:0036342)
3.8 11.5 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 9.1 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.9 8.6 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.3 8.4 GO:0070207 protein homotrimerization(GO:0070207)
2.6 7.8 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.7 7.6 GO:0060539 diaphragm development(GO:0060539)
1.0 7.3 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.3 6.8 GO:0030903 notochord development(GO:0030903)
0.2 6.8 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
2.1 6.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.2 6.1 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
1.0 6.0 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.9 5.7 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.3 5.5 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
1.1 5.3 GO:0035262 gonad morphogenesis(GO:0035262)
1.7 5.1 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 34.5 GO:0005667 transcription factor complex(GO:0005667)
2.3 20.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
2.1 8.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 8.1 GO:0072686 mitotic spindle(GO:0072686)
0.0 7.2 GO:0005802 trans-Golgi network(GO:0005802)
1.3 5.3 GO:0008623 CHRAC(GO:0008623)
0.6 5.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
1.7 5.0 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 4.8 GO:1990391 DNA repair complex(GO:1990391)
0.2 4.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 3.9 GO:0016580 Sin3 complex(GO:0016580)
1.9 3.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 3.8 GO:0005871 kinesin complex(GO:0005871)
0.3 3.4 GO:0030057 desmosome(GO:0030057)
0.1 3.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 3.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.5 3.0 GO:0000235 astral microtubule(GO:0000235)
0.2 2.9 GO:0044294 dendritic growth cone(GO:0044294)
0.1 2.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 2.9 GO:0005720 nuclear heterochromatin(GO:0005720)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 39.6 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.2 28.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.2 25.3 GO:0045295 gamma-catenin binding(GO:0045295)
1.4 21.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.4 11.5 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 10.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.1 8.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.4 8.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 7.5 GO:0070411 I-SMAD binding(GO:0070411)
0.2 7.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 6.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 6.6 GO:0003777 microtubule motor activity(GO:0003777)
2.0 6.1 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.7 6.0 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 5.9 GO:0003713 transcription coactivator activity(GO:0003713)
0.2 5.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.4 5.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 5.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 5.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.3 5.2 GO:0070410 co-SMAD binding(GO:0070410)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 45.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.4 17.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 8.8 PID_E2F_PATHWAY E2F transcription factor network
0.2 7.7 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.3 7.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.6 5.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 5.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 5.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.2 4.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 4.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 4.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 2.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.4 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 2.3 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 2.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.1 PID_SHP2_PATHWAY SHP2 signaling
0.3 2.0 PID_FOXO_PATHWAY FoxO family signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 14.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 10.4 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
1.4 8.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.4 7.0 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.3 6.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.4 5.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 5.1 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 4.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 4.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 3.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 2.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.6 REACTOME_MEIOSIS Genes involved in Meiosis
0.2 2.5 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 2.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.0 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.8 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 1.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 1.7 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.7 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 1.6 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex