Motif ID: Lhx2_Hoxc5

Z-value: 0.878

Transcription factors associated with Lhx2_Hoxc5:

Gene SymbolEntrez IDGene Name
Hoxc5 ENSMUSG00000022485.3 Hoxc5
Lhx2 ENSMUSG00000000247.5 Lhx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx2mm10_v2_chr2_+_38341068_38341092-0.438.4e-03Click!


Activity profile for motif Lhx2_Hoxc5.

activity profile for motif Lhx2_Hoxc5


Sorted Z-values histogram for motif Lhx2_Hoxc5

Sorted Z-values for motif Lhx2_Hoxc5



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx2_Hoxc5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 7.469 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chrX_+_170009892 3.612 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr19_-_32196393 3.444 ENSMUST00000151822.1
 Sgms1
sphingomyelin synthase 1
chr18_+_37435602 3.178 ENSMUST00000055495.5
 Pcdhb12
protocadherin beta 12
chr14_-_64455903 3.137 ENSMUST00000067927.7
 Msra
methionine sulfoxide reductase A
chr19_-_11604828 2.827 ENSMUST00000025582.4
 Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr15_-_37459327 2.475 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr4_-_14621669 2.402 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr2_+_65620829 2.337 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr8_+_66386292 2.327 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr4_-_138396438 2.236 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr4_-_14621494 2.227 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr6_+_116650674 2.123 ENSMUST00000067354.5
ENSMUST00000178241.1
 8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr3_+_9403049 2.082 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
 C030034L19Rik


RIKEN cDNA C030034L19 gene


chr5_-_43981757 2.075 ENSMUST00000061299.7
 Fgfbp1
fibroblast growth factor binding protein 1
chr3_+_63295815 2.055 ENSMUST00000029400.1
 Mme
membrane metallo endopeptidase
chr9_+_53771499 2.043 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr7_-_45103747 2.010 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr14_+_69347587 1.997 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr5_-_148371525 1.965 ENSMUST00000138596.1
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 176 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 12.1 GO:0019532 oxalate transport(GO:0019532)
0.4 4.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 3.7 GO:0007416 synapse assembly(GO:0007416)
0.4 3.6 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 3.6 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 2.5 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 2.3 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.7 2.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.3 2.1 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 2.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.7 2.0 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 2.0 GO:0015809 arginine transport(GO:0015809)
0.6 1.9 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 1.8 GO:0007568 aging(GO:0007568)
0.4 1.7 GO:0072592 regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592)
0.2 1.7 GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.2 1.7 GO:0070314 G1 to G0 transition(GO:0070314)
0.1 1.7 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 1.7 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.5 1.6 GO:0046110 xanthine metabolic process(GO:0046110)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 4.6 GO:0070469 respiratory chain(GO:0070469)
0.3 3.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 2.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 2.6 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 2.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.7 2.0 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.4 1.7 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.7 GO:0031045 dense core granule(GO:0031045)
0.0 1.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 1.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.4 1.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 1.5 GO:0044327 dendritic spine head(GO:0044327)
0.1 1.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 1.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 1.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 12.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 4.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.7 3.4 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
1.0 3.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 3.1 GO:0042287 MHC protein binding(GO:0042287)
0.1 2.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 2.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 2.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 2.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 2.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 2.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.4 2.0 GO:0019770 IgG receptor activity(GO:0019770)
0.4 2.0 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.3 2.0 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.2 2.0 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 1.8 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.6 1.7 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.4 1.6 GO:0030151 molybdenum ion binding(GO:0030151)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 2.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 1.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.4 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.1 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.9 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 0.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.7 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.7 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.7 PID_MTOR_4PATHWAY mTOR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 4.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 4.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 2.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.1 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 2.0 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.7 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 1.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 1.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.3 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 1.3 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.2 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 1.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.0 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi