Motif ID: Lhx3

Z-value: 0.772


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_14621805 5.816 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr7_-_103827922 4.425 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs

hemoglobin, beta adult s chain

chr7_-_45103747 4.228 ENSMUST00000003512.7
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr4_+_136143497 3.902 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr17_-_67950908 3.394 ENSMUST00000164647.1
Arhgap28
Rho GTPase activating protein 28
chr4_-_14621494 2.992 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr14_+_80000292 2.988 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr13_+_49608030 2.945 ENSMUST00000021822.5
Ogn
osteoglycin
chr4_-_14621669 2.881 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr4_+_102589687 2.545 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr2_+_125136692 2.496 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr19_+_26623419 2.451 ENSMUST00000176584.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_33087169 2.399 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr3_+_151437887 2.348 ENSMUST00000046977.7
Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr6_+_96115249 2.338 ENSMUST00000075080.5
Fam19a1
family with sequence similarity 19, member A1
chr2_-_33086366 2.337 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr13_-_101692624 2.279 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr1_+_177444653 2.221 ENSMUST00000094276.3
Zbtb18
zinc finger and BTB domain containing 18
chr1_-_38821215 2.117 ENSMUST00000039612.4
Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr5_+_66968961 2.070 ENSMUST00000132991.1
Limch1
LIM and calponin homology domains 1
chr2_-_164171113 1.870 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr3_+_84952146 1.753 ENSMUST00000029727.7
Fbxw7
F-box and WD-40 domain protein 7
chr6_+_34780412 1.708 ENSMUST00000115016.1
ENSMUST00000115017.1
Agbl3

ATP/GTP binding protein-like 3

chr8_-_21906412 1.588 ENSMUST00000051965.4
Defb11
defensin beta 11
chr11_+_109543694 1.549 ENSMUST00000106696.1
Arsg
arylsulfatase G
chr10_-_64090265 1.488 ENSMUST00000105439.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_33624587 1.485 ENSMUST00000160299.1
ENSMUST00000019920.6
Clvs2

clavesin 2

chr10_+_102158858 1.457 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr18_+_37477768 1.437 ENSMUST00000051442.5
Pcdhb16
protocadherin beta 16
chr5_-_118244861 1.412 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chrX_-_139871637 1.387 ENSMUST00000033811.7
ENSMUST00000087401.5
Morc4

microrchidia 4

chr6_+_124304646 1.358 ENSMUST00000112541.2
ENSMUST00000032234.2
Cd163

CD163 antigen

chr3_+_122419772 1.147 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr1_-_158356258 1.115 ENSMUST00000004133.8
Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr10_-_62507737 1.093 ENSMUST00000020271.6
Srgn
serglycin
chr7_-_45830776 1.069 ENSMUST00000107723.2
ENSMUST00000131384.1
Grwd1

glutamate-rich WD repeat containing 1

chr13_+_93304799 1.052 ENSMUST00000080127.5
Homer1
homer homolog 1 (Drosophila)
chr3_+_136670076 1.021 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr10_-_64090241 0.976 ENSMUST00000133588.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_35711891 0.877 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chr5_-_70842617 0.853 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr11_-_30198232 0.852 ENSMUST00000102838.3
Sptbn1
spectrin beta, non-erythrocytic 1
chr15_+_16778101 0.830 ENSMUST00000026432.6
Cdh9
cadherin 9
chr10_-_53647080 0.826 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr10_+_36506814 0.775 ENSMUST00000167191.1
ENSMUST00000058738.4
Hs3st5

heparan sulfate (glucosamine) 3-O-sulfotransferase 5

chr8_-_109251698 0.762 ENSMUST00000079189.3
4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr3_-_57294880 0.741 ENSMUST00000171384.1
Tm4sf1
transmembrane 4 superfamily member 1
chr2_+_36230426 0.733 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chrX_+_66653003 0.727 ENSMUST00000036043.4
Slitrk2
SLIT and NTRK-like family, member 2
chr4_-_147809788 0.611 ENSMUST00000105734.3
ENSMUST00000176201.1
Gm13157
Gm20707
predicted gene 13157
predicted gene 20707
chr11_+_59306920 0.579 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr15_+_98571004 0.560 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr14_+_69347587 0.560 ENSMUST00000064831.5
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr3_+_66985680 0.554 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr10_+_116143881 0.542 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr13_+_93304066 0.515 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr4_+_145585166 0.467 ENSMUST00000105739.1
ENSMUST00000119718.1
Gm13212

predicted gene 13212

chr2_+_82053222 0.431 ENSMUST00000047527.7
Zfp804a
zinc finger protein 804A
chr3_+_66985647 0.405 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr4_+_105789869 0.375 ENSMUST00000184254.1
Gm12728
predicted gene 12728
chr9_+_113812547 0.375 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr2_-_84425258 0.373 ENSMUST00000074262.2
Calcrl
calcitonin receptor-like
chr8_-_106573461 0.349 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr7_-_30534180 0.327 ENSMUST00000044338.4
Arhgap33
Rho GTPase activating protein 33
chr3_+_142620596 0.298 ENSMUST00000165774.1
Gbp2
guanylate binding protein 2
chr14_-_108914237 0.253 ENSMUST00000100322.2
Slitrk1
SLIT and NTRK-like family, member 1
chr18_+_60774510 0.232 ENSMUST00000025511.3
Rps14
ribosomal protein S14
chr16_+_11406618 0.227 ENSMUST00000122168.1
Snx29
sorting nexin 29
chr4_+_118961578 0.209 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1
chr1_-_36273425 0.198 ENSMUST00000056946.6
Neurl3
neuralized homolog 3 homolog (Drosophila)
chr7_+_100159241 0.192 ENSMUST00000032967.3
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr10_+_5593718 0.190 ENSMUST00000051809.8
Myct1
myc target 1
chrX_+_166344692 0.181 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
Gpm6b





glycoprotein m6b





chr18_+_60774675 0.175 ENSMUST00000118551.1
Rps14
ribosomal protein S14
chr17_-_36032682 0.172 ENSMUST00000102678.4
H2-T23
histocompatibility 2, T region locus 23
chr18_+_57468478 0.172 ENSMUST00000091892.2
Ctxn3
cortexin 3
chrM_+_9452 0.146 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chrX_-_143933204 0.128 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr5_-_51553896 0.120 ENSMUST00000132734.1
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr4_+_145510759 0.089 ENSMUST00000105742.1
ENSMUST00000136309.1
Gm13225

predicted gene 13225

chr11_-_4095344 0.046 ENSMUST00000004868.5
Mtfp1
mitochondrial fission process 1
chr5_+_122422440 0.027 ENSMUST00000031422.3
ENSMUST00000119792.1
Anapc7

anaphase promoting complex subunit 7

chr5_-_62765618 0.015 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_147132038 0.009 ENSMUST00000084149.3
Gm13139
predicted gene 13139

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 11.7 GO:0019532 oxalate transport(GO:0019532)
0.8 3.4 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.4 1.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.4 1.8 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.3 1.0 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.3 0.9 GO:0006597 spermine biosynthetic process(GO:0006597)
0.3 1.7 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.3 2.5 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 2.3 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 2.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 0.7 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.2 2.5 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.2 3.9 GO:0030903 notochord development(GO:0030903)
0.1 0.5 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.8 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.9 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 1.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.4 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 0.2 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 1.9 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1 1.1 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 1.4 GO:0006953 acute-phase response(GO:0006953)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 1.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 3.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.1 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.0 0.2 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 1.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.0 GO:0046677 response to antibiotic(GO:0046677)
0.0 2.2 GO:0021766 hippocampus development(GO:0021766)
0.0 2.1 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 1.5 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.0 4.5 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 1.1 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.6 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 1.6 GO:0042742 defense response to bacterium(GO:0042742)
0.0 2.1 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.4 1.8 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 3.0 GO:0042581 specific granule(GO:0042581)
0.2 0.6 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.2 0.9 GO:0032437 cuticular plate(GO:0032437)
0.2 1.0 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.1 GO:0042629 mast cell granule(GO:0042629)
0.1 2.5 GO:0071564 npBAF complex(GO:0071564)
0.1 2.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 1.6 GO:0043034 costamere(GO:0043034)
0.0 1.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 10.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 1.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.5 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 3.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.4 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
1.1 11.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.8 4.2 GO:0019770 IgG receptor activity(GO:0019770)
0.6 2.3 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.4 1.8 GO:0050816 phosphothreonine binding(GO:0050816)
0.3 1.5 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 0.9 GO:0019808 polyamine binding(GO:0019808)
0.2 1.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.6 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.8 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 1.5 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 1.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 3.6 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.6 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 2.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 1.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 2.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.9 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.4 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.0 2.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.9 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.9 GO:0008083 growth factor activity(GO:0008083)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 2.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.1 GO:0005518 collagen binding(GO:0005518)
0.0 0.7 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 4.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.8 PID_MYC_PATHWAY C-MYC pathway
0.0 3.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.2 1.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 2.3 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 11.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.8 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.9 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 2.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)