Motif ID: Lhx4
Z-value: 1.357
Transcription factors associated with Lhx4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Lhx4 | ENSMUSG00000026468.8 | Lhx4 |
Top targets:
Showing 1 to 20 of 198 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 82 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.6 | 28.9 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
| 1.4 | 21.6 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.7 | 9.7 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
| 0.5 | 9.0 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 1.2 | 8.5 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 1.6 | 8.2 | GO:0038027 | apolipoprotein A-I-mediated signaling pathway(GO:0038027) |
| 1.9 | 7.7 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 5.5 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 1.8 | 5.4 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.1 | 5.4 | GO:0030901 | midbrain development(GO:0030901) |
| 1.7 | 5.2 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 0.4 | 4.8 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 4.6 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 1.1 | 4.4 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.8 | 4.2 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.5 | 4.2 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.1 | 3.9 | GO:0009063 | cellular amino acid catabolic process(GO:0009063) |
| 0.0 | 3.9 | GO:0006906 | vesicle fusion(GO:0006906) |
| 0.2 | 3.7 | GO:0003334 | keratinocyte development(GO:0003334) |
| 1.2 | 3.6 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 40 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.7 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.1 | 9.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.6 | 8.5 | GO:0045180 | basal cortex(GO:0045180) |
| 0.4 | 7.7 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.2 | 6.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 5.5 | GO:0016459 | myosin complex(GO:0016459) |
| 1.3 | 5.2 | GO:0060187 | cell pole(GO:0060187) |
| 0.0 | 5.2 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 4.2 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 3.9 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.1 | 3.7 | GO:0002102 | podosome(GO:0002102) |
| 1.2 | 3.6 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.1 | 2.6 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.5 | 2.5 | GO:0031523 | Myb complex(GO:0031523) |
| 0.3 | 2.5 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.7 | 2.0 | GO:0034684 | integrin alphav-beta5 complex(GO:0034684) |
| 0.4 | 2.0 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 0.0 | 1.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 1.7 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 1.6 | GO:0036064 | ciliary basal body(GO:0036064) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 64 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 37.2 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 1.4 | 21.6 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 17.4 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.3 | 12.1 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.2 | 9.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 8.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 7.0 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 2.1 | 6.2 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.2 | 5.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 5.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 1.4 | 5.4 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.1 | 4.2 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.2 | 4.1 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 1.3 | 3.9 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
| 0.1 | 3.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 3.9 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.2 | 3.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 3.7 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.4 | 3.6 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.3 | 3.6 | GO:0070513 | death domain binding(GO:0070513) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 25 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 28.9 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.3 | 12.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.3 | 9.8 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.2 | 9.2 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.2 | 6.7 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 3.8 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.1 | 3.7 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.7 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 3.4 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 3.0 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 2.5 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.1 | 2.5 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 2.0 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.8 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.1 | 1.5 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.1 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.0 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.9 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.8 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 0.7 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 31 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.3 | 7.7 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.3 | 6.2 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 5.5 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.2 | 4.1 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.3 | 3.7 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 3.5 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 3.5 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 3.2 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 3.0 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.4 | 2.5 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 2.1 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 2.0 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 2.0 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.9 | REACTOME_DIABETES_PATHWAYS | Genes involved in Diabetes pathways |
| 0.0 | 1.8 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.5 | 1.6 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.2 | 1.2 | REACTOME_ANDROGEN_BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.1 | 1.2 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.2 | REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
