Motif ID: Lhx5_Lmx1b_Lhx1

Z-value: 0.481

Transcription factors associated with Lhx5_Lmx1b_Lhx1:

Gene SymbolEntrez IDGene Name
Lhx1 ENSMUSG00000018698.9 Lhx1
Lhx5 ENSMUSG00000029595.7 Lhx5
Lmx1b ENSMUSG00000038765.7 Lmx1b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx5mm10_v2_chr5_+_120431770_120431905-0.421.1e-02Click!
Lhx1mm10_v2_chr11_-_84525514_84525542-0.382.0e-02Click!
Lmx1bmm10_v2_chr2_-_33640480_33640511-0.134.4e-01Click!


Activity profile for motif Lhx5_Lmx1b_Lhx1.

activity profile for motif Lhx5_Lmx1b_Lhx1


Sorted Z-values histogram for motif Lhx5_Lmx1b_Lhx1

Sorted Z-values for motif Lhx5_Lmx1b_Lhx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx5_Lmx1b_Lhx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_93595877 3.157 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr3_+_121953213 2.839 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr4_+_102589687 2.620 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr7_+_66365905 2.218 ENSMUST00000107486.1
 Gm10974
predicted gene 10974
chr4_-_14621805 1.982 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr18_-_66860458 1.963 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr14_+_80000292 1.691 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr13_+_46502113 1.447 ENSMUST00000119341.1
 Cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr11_-_87359011 1.383 ENSMUST00000055438.4
 Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr10_+_97482350 1.239 ENSMUST00000163448.2
 Dcn
decorin
chr5_+_13398688 1.217 ENSMUST00000125629.1
 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr15_-_67113909 1.173 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chrX_-_143933089 1.124 ENSMUST00000087313.3
 Dcx
doublecortin
chr2_+_68104671 0.968 ENSMUST00000042456.3
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr8_-_67910911 0.963 ENSMUST00000093468.5
 Psd3
pleckstrin and Sec7 domain containing 3
chr4_+_102421518 0.948 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_101986626 0.872 ENSMUST00000106914.1
 Gm12789
predicted gene 12789
chr16_+_11406618 0.851 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr5_+_130369420 0.838 ENSMUST00000086029.3
 Caln1
calneuron 1
chr13_+_77135513 0.834 ENSMUST00000168779.1
 2210408I21Rik
RIKEN cDNA 2210408I21 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
1.1 3.2 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.4 3.1 GO:0019532 oxalate transport(GO:0019532)
0.4 2.0 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 1.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 1.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 1.4 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.4 1.3 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.2 1.2 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.2 1.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 1.2 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 1.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 1.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 0.7 GO:0046110 xanthine metabolic process(GO:0046110)
0.2 0.7 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.6 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 0.6 GO:0042428 serotonin metabolic process(GO:0042428)
0.1 0.5 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.5 GO:0003406 retinal pigment epithelium development(GO:0003406)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 3.0 GO:0031965 nuclear membrane(GO:0031965)
0.1 1.7 GO:0042581 specific granule(GO:0042581)
0.1 1.2 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 1.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.5 GO:0010369 chromocenter(GO:0010369)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.3 GO:0002177 manchette(GO:0002177)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.2 GO:0090543 Flemming body(GO:0090543)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 3.3 GO:0030165 PDZ domain binding(GO:0030165)
0.3 3.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.7 2.0 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 1.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.3 GO:0030275 LRR domain binding(GO:0030275)
0.3 1.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 1.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 1.0 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 1.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 0.7 GO:0030151 molybdenum ion binding(GO:0030151)
0.2 0.7 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 0.6 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.5 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.9 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.3 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 3.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 2.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.6 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 1.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.4 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.2 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 0.7 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
0.1 0.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell