Motif ID: Lhx8

Z-value: 0.530


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.231.8e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Showing 1 to 20 of 100 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_66227573 3.589 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr13_-_66851513 1.635 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr13_-_66852017 1.620 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr1_+_6487231 1.293 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr8_-_57653023 1.027 ENSMUST00000034021.5
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr10_-_67912620 0.964 ENSMUST00000064656.7
 Zfp365
zinc finger protein 365
chr8_-_57652993 0.878 ENSMUST00000110316.2
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr13_+_5861489 0.878 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr2_-_72986716 0.803 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr12_+_38783455 0.772 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr11_+_44617310 0.666 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr7_+_91090728 0.658 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090697 0.656 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr12_+_38783503 0.621 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr2_+_65620829 0.582 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr4_-_155645408 0.573 ENSMUST00000115821.2
 Gm10563
predicted gene 10563
chr2_-_67433181 0.518 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr18_+_23415400 0.511 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr1_-_127677923 0.500 ENSMUST00000160616.1
 Tmem163
transmembrane protein 163
chr3_-_73056943 0.479 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 1.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 1.3 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.3 1.0 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.7 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.2 0.5 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.4 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.4 GO:0019227 neuronal action potential propagation(GO:0019227) detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) action potential propagation(GO:0098870)
0.1 0.3 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1 0.3 GO:0070343 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.1 0.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.3 GO:0090234 cellular response to testosterone stimulus(GO:0071394) regulation of kinetochore assembly(GO:0090234)
0.0 0.3 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.3 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.2 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.0 0.2 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.1 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.5 GO:0060187 cell pole(GO:0060187)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.3 GO:0031673 H zone(GO:0031673)
0.1 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 0.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.7 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 0.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.4 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.3 GO:0033142 progesterone receptor binding(GO:0033142)
0.0 0.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0035497 cAMP response element binding(GO:0035497)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.3 PID_FANCONI_PATHWAY Fanconi anemia pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors