Motif ID: Lhx8

Z-value: 0.530


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.231.8e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_66227573 3.589 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr13_-_66851513 1.635 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr13_-_66852017 1.620 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr1_+_6487231 1.293 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr8_-_57653023 1.027 ENSMUST00000034021.5
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr10_-_67912620 0.964 ENSMUST00000064656.7
 Zfp365
zinc finger protein 365
chr8_-_57652993 0.878 ENSMUST00000110316.2
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr13_+_5861489 0.878 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr2_-_72986716 0.803 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr12_+_38783455 0.772 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr11_+_44617310 0.666 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr7_+_91090728 0.658 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090697 0.656 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr12_+_38783503 0.621 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr2_+_65620829 0.582 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr4_-_155645408 0.573 ENSMUST00000115821.2
 Gm10563
predicted gene 10563
chr2_-_67433181 0.518 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr18_+_23415400 0.511 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr1_-_127677923 0.500 ENSMUST00000160616.1
 Tmem163
transmembrane protein 163
chr3_-_73056943 0.479 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr18_-_43687695 0.464 ENSMUST00000082254.6
 Jakmip2
janus kinase and microtubule interacting protein 2
chr8_-_69373383 0.442 ENSMUST00000072427.4
 Gm10033
predicted gene 10033
chr4_+_126556994 0.433 ENSMUST00000147675.1
 Clspn
claspin
chr10_-_4432285 0.421 ENSMUST00000155172.1
 Rmnd1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr17_-_35027909 0.409 ENSMUST00000040151.2
 Sapcd1
suppressor APC domain containing 1
chr16_-_16829276 0.400 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr9_-_124493793 0.398 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr3_-_116712696 0.376 ENSMUST00000169530.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr8_+_45627709 0.371 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr15_+_21111452 0.367 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr2_-_52558539 0.361 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr1_-_172027251 0.345 ENSMUST00000138714.1
 Vangl2
vang-like 2 (van gogh, Drosophila)
chr3_+_76075583 0.328 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr13_-_62466709 0.322 ENSMUST00000076195.5
 Zfp935
zinc finger protein 935
chr2_-_114013619 0.307 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr5_+_34336289 0.296 ENSMUST00000182709.1
ENSMUST00000030992.6
 Rnf4

ring finger protein 4

chr10_+_58497918 0.282 ENSMUST00000036576.8
 Ccdc138
coiled-coil domain containing 138
chr6_-_136173492 0.281 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr11_+_98798653 0.278 ENSMUST00000037930.6
 Msl1
male-specific lethal 1 homolog (Drosophila)
chr4_-_62502233 0.277 ENSMUST00000037820.2
 Hdhd3
haloacid dehalogenase-like hydrolase domain containing 3
chr19_-_24961545 0.264 ENSMUST00000025815.8
 Cbwd1
COBW domain containing 1
chr6_+_11926758 0.263 ENSMUST00000133776.1
 Phf14
PHD finger protein 14
chr1_+_33908172 0.263 ENSMUST00000182513.1
ENSMUST00000183034.1
 Dst

dystonin

chr11_+_16257706 0.260 ENSMUST00000109645.2
ENSMUST00000109647.2
 Vstm2a

V-set and transmembrane domain containing 2A

chr15_-_98221056 0.258 ENSMUST00000170618.1
ENSMUST00000141911.1
 Olfr287

olfactory receptor 287

chr10_-_4432312 0.243 ENSMUST00000126102.1
ENSMUST00000131853.1
ENSMUST00000042251.4
 Rmnd1


required for meiotic nuclear division 1 homolog (S. cerevisiae)


chr11_-_102579071 0.240 ENSMUST00000107080.1
 Gm11627
predicted gene 11627
chr12_-_20900867 0.229 ENSMUST00000079237.5
 Zfp125
zinc finger protein 125
chr7_-_28372597 0.228 ENSMUST00000144700.1
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr3_-_59210881 0.222 ENSMUST00000040622.1
 P2ry13
purinergic receptor P2Y, G-protein coupled 13
chrX_-_163761323 0.219 ENSMUST00000059320.2
 Rnf138rt1
ring finger protein 138, retrogene 1
chr4_+_53011916 0.216 ENSMUST00000107665.3
 Nipsnap3b
nipsnap homolog 3B (C. elegans)
chr1_+_161969179 0.209 ENSMUST00000111594.2
ENSMUST00000028021.6
 Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr8_+_110079758 0.190 ENSMUST00000058804.8
 Zfp612
zinc finger protein 612
chr14_+_60768120 0.181 ENSMUST00000025940.6
 C1qtnf9
C1q and tumor necrosis factor related protein 9
chr11_+_26387194 0.180 ENSMUST00000109509.1
ENSMUST00000136830.1
 Fancl

Fanconi anemia, complementation group L

chr11_-_109995775 0.179 ENSMUST00000020948.8
 Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr17_-_90088343 0.175 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr1_+_72284367 0.171 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr2_-_114175321 0.170 ENSMUST00000043160.6
 Aqr
aquarius
chr7_-_28372233 0.169 ENSMUST00000094644.4
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr9_+_44334685 0.167 ENSMUST00000052686.2
 H2afx
H2A histone family, member X
chr1_-_172027269 0.166 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr3_-_100685431 0.155 ENSMUST00000008907.7
 Man1a2
mannosidase, alpha, class 1A, member 2
chr13_+_65512678 0.154 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr7_-_28372494 0.151 ENSMUST00000119990.1
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr11_-_102579461 0.145 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr1_+_86064619 0.141 ENSMUST00000027432.8
 Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr4_-_41314877 0.125 ENSMUST00000030145.8
 Dcaf12
DDB1 and CUL4 associated factor 12
chr18_-_31911903 0.123 ENSMUST00000054984.6
 Sft2d3
SFT2 domain containing 3
chr10_-_19907545 0.117 ENSMUST00000134220.1
 Pex7
peroxisomal biogenesis factor 7
chr5_+_121795034 0.115 ENSMUST00000162327.1
 Atxn2
ataxin 2
chr14_+_48446128 0.099 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chr18_+_27598582 0.097 ENSMUST00000050143.3
 Gm7729
predicted gene 7729
chr6_-_71440623 0.096 ENSMUST00000002292.8
 Rmnd5a
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr2_+_73312601 0.094 ENSMUST00000090811.4
ENSMUST00000112050.1
 Scrn3

secernin 3

chr9_-_78378725 0.092 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr15_-_83595111 0.090 ENSMUST00000016901.3
 Ttll12
tubulin tyrosine ligase-like family, member 12
chr1_-_74588117 0.089 ENSMUST00000066986.6
 Zfp142
zinc finger protein 142
chr3_+_89773562 0.089 ENSMUST00000038356.8
 Ube2q1
ubiquitin-conjugating enzyme E2Q (putative) 1
chr7_+_12977834 0.082 ENSMUST00000108537.1
ENSMUST00000108535.1
ENSMUST00000045810.7
 Zfp446


zinc finger protein 446


chr2_+_21205719 0.081 ENSMUST00000054591.3
ENSMUST00000102952.1
ENSMUST00000138965.1
ENSMUST00000138914.1
ENSMUST00000102951.1
 Thnsl1




threonine synthase-like 1 (bacterial)




chr5_+_137553517 0.073 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr1_-_170867761 0.064 ENSMUST00000027974.6
 Atf6
activating transcription factor 6
chr5_-_98566762 0.045 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr1_+_17145357 0.040 ENSMUST00000026879.7
 Gdap1
ganglioside-induced differentiation-associated-protein 1
chr1_-_44218952 0.036 ENSMUST00000054801.3
 Mettl21e
methyltransferase like 21E
chr19_-_11336107 0.036 ENSMUST00000056035.2
ENSMUST00000067532.4
 Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr3_-_116712644 0.029 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr5_+_67306941 0.029 ENSMUST00000162372.1
ENSMUST00000113676.2
 Slc30a9

solute carrier family 30 (zinc transporter), member 9

chr7_-_60005049 0.025 ENSMUST00000179360.1
 Snurf
SNRPN upstream reading frame
chr8_+_34054622 0.023 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr17_+_8182247 0.023 ENSMUST00000161898.1
 Fgfr1op
Fgfr1 oncogene partner
chr12_+_4082596 0.016 ENSMUST00000049584.5
 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr7_-_60005101 0.013 ENSMUST00000059305.10
 Snrpn
small nuclear ribonucleoprotein N
chr2_-_45110336 0.009 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr4_+_126556935 0.008 ENSMUST00000048391.8
 Clspn
claspin
chr1_-_45890078 0.008 ENSMUST00000183590.1
 Gm5269
predicted gene 5269
chr3_+_107291215 0.008 ENSMUST00000029502.7
 Slc16a4
solute carrier family 16 (monocarboxylic acid transporters), member 4
chr1_+_164048214 0.005 ENSMUST00000027874.5
 Sele
selectin, endothelial cell

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.2 0.5 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 1.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 1.3 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 0.3 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1 0.3 GO:0070343 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.1 0.4 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 0.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.7 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.2 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.0 0.3 GO:0090234 cellular response to testosterone stimulus(GO:0071394) regulation of kinetochore assembly(GO:0090234)
0.0 0.4 GO:0019227 neuronal action potential propagation(GO:0019227) detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) action potential propagation(GO:0098870)
0.0 1.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.1 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.2 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.3 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.3 GO:0008090 retrograde axonal transport(GO:0008090)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0060187 cell pole(GO:0060187)
0.1 0.3 GO:0031673 H zone(GO:0031673)
0.1 1.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 1.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.3 GO:0033142 progesterone receptor binding(GO:0033142)
0.0 0.7 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.4 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0035497 cAMP response element binding(GO:0035497)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.3 PID_FANCONI_PATHWAY Fanconi anemia pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions