Motif ID: Mafa

Z-value: 1.087


Transcription factors associated with Mafa:

Gene SymbolEntrez IDGene Name
Mafa ENSMUSG00000047591.4 Mafa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafamm10_v2_chr15_-_75747922_75747922-0.617.2e-05Click!


Activity profile for motif Mafa.

activity profile for motif Mafa


Sorted Z-values histogram for motif Mafa

Sorted Z-values for motif Mafa



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafa

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_119138415 10.274 ENSMUST00000065904.3
Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr9_-_98032983 10.274 ENSMUST00000162295.1
Clstn2
calsyntenin 2
chr9_-_98033181 9.053 ENSMUST00000035027.6
Clstn2
calsyntenin 2
chr4_+_102254739 8.048 ENSMUST00000106907.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_102254993 7.180 ENSMUST00000106908.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr1_-_136260873 6.835 ENSMUST00000086395.5
Gpr25
G protein-coupled receptor 25
chr1_-_169747634 5.652 ENSMUST00000027991.5
ENSMUST00000111357.1
Rgs4

regulator of G-protein signaling 4

chr16_-_17576631 5.476 ENSMUST00000164545.1
ENSMUST00000164490.1
ENSMUST00000172164.1
Slc7a4


solute carrier family 7 (cationic amino acid transporter, y+ system), member 4


chr16_+_91269759 4.261 ENSMUST00000056882.5
Olig1
oligodendrocyte transcription factor 1
chr2_-_125506385 3.818 ENSMUST00000028633.6
Fbn1
fibrillin 1
chr8_-_70487314 3.559 ENSMUST00000045286.7
Tmem59l
transmembrane protein 59-like
chr11_-_66525964 3.500 ENSMUST00000066679.6
Shisa6
shisa homolog 6 (Xenopus laevis)
chr19_+_27217011 3.494 ENSMUST00000164746.1
ENSMUST00000172302.1
Vldlr

very low density lipoprotein receptor

chr11_-_66525795 3.335 ENSMUST00000123454.1
Shisa6
shisa homolog 6 (Xenopus laevis)
chr19_+_27217357 3.322 ENSMUST00000047645.6
ENSMUST00000167487.1
Vldlr

very low density lipoprotein receptor

chr1_-_38836090 3.225 ENSMUST00000147695.1
Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr5_-_142509653 2.911 ENSMUST00000110784.1
Radil
Ras association and DIL domains
chr13_+_4233730 2.696 ENSMUST00000081326.6
Akr1c19
aldo-keto reductase family 1, member C19
chr18_-_36197343 2.522 ENSMUST00000115713.1
ENSMUST00000115712.1
Nrg2

neuregulin 2

chr5_-_124187150 2.437 ENSMUST00000161938.1
Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr10_+_58813359 2.373 ENSMUST00000135526.2
ENSMUST00000153031.1
Sh3rf3

SH3 domain containing ring finger 3

chr4_+_42035113 2.330 ENSMUST00000098127.1
Gm10597
predicted gene 10597
chr10_-_75932468 2.320 ENSMUST00000120281.1
ENSMUST00000000924.6
Mmp11

matrix metallopeptidase 11

chrX_-_73869804 2.144 ENSMUST00000066576.5
ENSMUST00000114430.1
L1cam

L1 cell adhesion molecule

chr5_+_111417263 2.099 ENSMUST00000094463.4
Mn1
meningioma 1
chr9_-_48835932 1.957 ENSMUST00000093852.3
Zbtb16
zinc finger and BTB domain containing 16
chr9_-_105131775 1.835 ENSMUST00000035179.6
Nudt16
nudix (nucleoside diphosphate linked moiety X)-type motif 16
chr8_+_93810832 1.828 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr9_-_51077064 1.827 ENSMUST00000098782.3
Layn
layilin
chr12_-_86884808 1.811 ENSMUST00000038422.6
Irf2bpl
interferon regulatory factor 2 binding protein-like
chr6_-_35308110 1.746 ENSMUST00000031868.4
Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr7_+_54835959 1.744 ENSMUST00000082373.6
Luzp2
leucine zipper protein 2
chr4_+_43406435 1.644 ENSMUST00000098106.2
ENSMUST00000139198.1
Rusc2

RUN and SH3 domain containing 2

chr12_+_3365108 1.620 ENSMUST00000020999.5
Kif3c
kinesin family member 3C
chr2_-_166155272 1.581 ENSMUST00000088086.3
Sulf2
sulfatase 2
chr17_-_46752170 1.526 ENSMUST00000121671.1
ENSMUST00000059844.6
Cnpy3

canopy 3 homolog (zebrafish)

chr16_-_74411292 1.519 ENSMUST00000117200.1
Robo2
roundabout homolog 2 (Drosophila)
chr10_-_84440591 1.484 ENSMUST00000020220.8
Nuak1
NUAK family, SNF1-like kinase, 1
chr4_-_35845204 1.333 ENSMUST00000164772.1
ENSMUST00000065173.2
Lingo2

leucine rich repeat and Ig domain containing 2

chrX_+_152178945 1.275 ENSMUST00000096275.4
Iqsec2
IQ motif and Sec7 domain 2
chrX_-_95444789 1.064 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr16_-_74411776 1.000 ENSMUST00000116586.2
Robo2
roundabout homolog 2 (Drosophila)
chr8_-_105565985 0.971 ENSMUST00000013304.7
Atp6v0d1
ATPase, H+ transporting, lysosomal V0 subunit D1
chr17_-_47010513 0.935 ENSMUST00000113337.2
ENSMUST00000113335.2
Ubr2

ubiquitin protein ligase E3 component n-recognin 2

chr11_+_50174839 0.907 ENSMUST00000020647.3
3010026O09Rik
RIKEN cDNA 3010026O09 gene
chr8_+_105373265 0.861 ENSMUST00000160650.1
Plekhg4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr10_-_81600857 0.839 ENSMUST00000151858.1
ENSMUST00000142948.1
ENSMUST00000072020.2
Tle6


transducin-like enhancer of split 6, homolog of Drosophila E(spl)


chr13_+_93771656 0.831 ENSMUST00000091403.4
Arsb
arylsulfatase B
chr11_-_107337556 0.794 ENSMUST00000040380.6
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr14_+_64588112 0.764 ENSMUST00000181808.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr11_-_59787636 0.730 ENSMUST00000125307.1
Pld6
phospholipase D family, member 6
chr17_-_47611449 0.693 ENSMUST00000024783.8
Bysl
bystin-like
chr7_-_67759735 0.690 ENSMUST00000074233.4
ENSMUST00000051389.8
Synm

synemin, intermediate filament protein

chr4_+_21931291 0.687 ENSMUST00000029908.7
Faxc
failed axon connections homolog (Drosophila)
chr5_+_24423805 0.642 ENSMUST00000153274.1
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr8_-_84937347 0.604 ENSMUST00000109741.2
ENSMUST00000119820.1
Mast1

microtubule associated serine/threonine kinase 1

chr11_-_119228461 0.591 ENSMUST00000036113.3
Tbc1d16
TBC1 domain family, member 16
chr13_+_55445301 0.590 ENSMUST00000001115.8
ENSMUST00000099482.3
Grk6

G protein-coupled receptor kinase 6

chr1_+_87183310 0.518 ENSMUST00000044533.8
Prss56
protease, serine 56
chr7_+_140856957 0.417 ENSMUST00000026558.6
Ric8
resistance to inhibitors of cholinesterase 8 homolog (C. elegans)
chr4_+_59003121 0.416 ENSMUST00000095070.3
ENSMUST00000174664.1
Dnajc25
Gm20503
DnaJ (Hsp40) homolog, subfamily C, member 25
predicted gene 20503
chr12_+_105453831 0.388 ENSMUST00000178224.1
D430019H16Rik
RIKEN cDNA D430019H16 gene
chr19_+_5474681 0.362 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chrX_-_20950597 0.359 ENSMUST00000009550.7
Elk1
ELK1, member of ETS oncogene family
chr13_+_96924674 0.312 ENSMUST00000171324.1
Gcnt4
glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
chr5_-_24423516 0.311 ENSMUST00000030814.6
Cdk5
cyclin-dependent kinase 5
chr17_+_47611570 0.288 ENSMUST00000024778.2
Med20
mediator complex subunit 20
chr9_-_109059711 0.288 ENSMUST00000061973.4
Trex1
three prime repair exonuclease 1
chr9_+_108002501 0.198 ENSMUST00000035214.4
ENSMUST00000175874.1
Ip6k1

inositol hexaphosphate kinase 1

chr1_+_171213969 0.164 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
Nr1i3


nuclear receptor subfamily 1, group I, member 3


chr4_+_155601854 0.146 ENSMUST00000118607.1
Slc35e2
solute carrier family 35, member E2
chr11_+_87595646 0.108 ENSMUST00000134216.1
Mtmr4
myotubularin related protein 4
chr2_-_92401237 0.065 ENSMUST00000050312.2
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr11_+_98927785 0.011 ENSMUST00000107474.1
Rara
retinoic acid receptor, alpha
chr9_-_45906837 0.006 ENSMUST00000161203.1
ENSMUST00000058720.5
ENSMUST00000160699.1
Rnf214


ring finger protein 214



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 10.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
1.4 6.8 GO:0034436 glycoprotein transport(GO:0034436)
1.3 3.8 GO:1903011 negative regulation of bone development(GO:1903011)
1.2 15.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.8 2.5 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.5 1.8 GO:0046709 IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)
0.4 1.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.4 2.0 GO:0048133 NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.3 6.8 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.3 2.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.3 21.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 0.9 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 0.6 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.2 1.1 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.2 1.5 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.2 1.8 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.2 5.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 0.7 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.1 2.3 GO:0030574 collagen catabolic process(GO:0030574)
0.1 1.7 GO:0008272 sulfate transport(GO:0008272)
0.1 0.3 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 5.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 0.8 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.1 1.3 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 0.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 4.3 GO:0048663 neuron fate commitment(GO:0048663)
0.0 1.8 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
0.0 0.7 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.7 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 3.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 2.5 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 2.9 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 1.6 GO:0072384 organelle transport along microtubule(GO:0072384)
0.0 0.8 GO:0007584 response to nutrient(GO:0007584)
0.0 1.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.6 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.6 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 0.9 GO:0090630 activation of GTPase activity(GO:0090630)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 15.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.6 6.8 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.3 3.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.2 2.2 GO:0044294 dendritic growth cone(GO:0044294)
0.2 1.6 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.2 6.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.3 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.7 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 2.5 GO:0030673 axolemma(GO:0030673)
0.1 0.7 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 19.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.3 GO:0016592 mediator complex(GO:0016592)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)
0.0 4.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 10.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
2.3 6.8 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.8 2.5 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.5 15.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.4 2.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.4 2.1 GO:0033691 sialic acid binding(GO:0033691)
0.3 1.8 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.3 1.8 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.3 2.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 2.0 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 1.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 0.9 GO:0070728 leucine binding(GO:0070728)
0.1 5.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.6 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 3.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.3 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 3.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.8 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 5.5 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.2 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 0.7 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 1.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 2.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 12.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.7 GO:0019894 kinesin binding(GO:0019894)
0.0 1.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 1.5 GO:0002039 p53 binding(GO:0002039)
0.0 0.7 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 2.2 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 5.4 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 2.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.8 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 2.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 3.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 PID_EPHA_FWDPATHWAY EPHA forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.4 15.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 10.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 1.5 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.2 2.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.5 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 0.8 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 5.7 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 2.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 2.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.6 REACTOME_KINESINS Genes involved in Kinesins
0.0 3.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets