Motif ID: Mafb

Z-value: 0.549


Transcription factors associated with Mafb:

Gene SymbolEntrez IDGene Name
Mafb ENSMUSG00000074622.3 Mafb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafbmm10_v2_chr2_-_160367057_160367073-0.057.5e-01Click!


Activity profile for motif Mafb.

activity profile for motif Mafb


Sorted Z-values histogram for motif Mafb

Sorted Z-values for motif Mafb



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafb

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136886187 3.270 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr7_-_120202104 3.067 ENSMUST00000033198.5
 Crym
crystallin, mu
chr2_+_170731807 2.434 ENSMUST00000029075.4
 Dok5
docking protein 5
chr18_+_65873478 2.430 ENSMUST00000025395.8
ENSMUST00000173530.1
 Grp

gastrin releasing peptide

chr7_+_130936172 2.317 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr9_-_77347816 2.048 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr9_-_77347787 1.610 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr7_-_141010759 1.564 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr13_-_23710714 1.502 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr17_+_3532554 1.321 ENSMUST00000168560.1
 Cldn20
claudin 20
chr17_+_22689771 1.305 ENSMUST00000055305.8
 Gm9805
predicted gene 9805
chr8_+_25532125 1.226 ENSMUST00000167764.1
 Fgfr1
fibroblast growth factor receptor 1
chr7_-_110862944 1.224 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr19_+_26753588 1.183 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr3_+_65109343 1.168 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr14_+_80000292 1.164 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr19_-_5510467 1.160 ENSMUST00000070172.4
 Snx32
sorting nexin 32
chr9_-_77347889 1.146 ENSMUST00000185039.1
 Mlip
muscular LMNA-interacting protein
chr4_-_41124292 1.076 ENSMUST00000030138.8
 Nol6
nucleolar protein family 6 (RNA-associated)
chr4_+_102421518 1.048 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 3.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.6 3.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.8 2.4 GO:0061744 motor behavior(GO:0061744) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.2 2.4 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.4 2.3 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.1 1.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.5 1.5 GO:0002725 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of T cell cytokine production(GO:0002725)
0.4 1.2 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.1 1.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 1.2 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.1 1.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 1.2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.3 1.1 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 1.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 1.1 GO:0007605 sensory perception of sound(GO:0007605)
0.2 1.0 GO:0051012 microtubule sliding(GO:0051012)
0.2 1.0 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 1.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.0 GO:0042092 type 2 immune response(GO:0042092)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0016605 PML body(GO:0016605)
0.0 3.3 GO:0005581 collagen trimer(GO:0005581)
0.3 1.5 GO:1990357 terminal web(GO:1990357)
0.1 1.2 GO:0042581 specific granule(GO:0042581)
0.1 1.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.1 GO:0032040 small-subunit processome(GO:0032040)
0.3 1.0 GO:0045160 myosin I complex(GO:0045160)
0.1 1.0 GO:0097228 sperm principal piece(GO:0097228)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.9 GO:0044754 secondary lysosome(GO:0005767) autolysosome(GO:0044754)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 0.8 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.8 GO:0030315 T-tubule(GO:0030315)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.6 GO:0002177 manchette(GO:0002177)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.3 3.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 2.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 2.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 2.3 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 1.5 GO:0039706 co-receptor binding(GO:0039706)
0.1 1.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 1.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 1.0 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 1.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 0.9 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.9 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.2 0.8 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.1 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.8 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.3 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.8 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.5 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.2 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 2.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 1.6 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.2 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 1.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.2 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.8 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.6 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors