Motif ID: Maff

Z-value: 0.828


Transcription factors associated with Maff:

Gene SymbolEntrez IDGene Name
Maff ENSMUSG00000042622.7 Maff

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maffmm10_v2_chr15_+_79347534_793475560.492.2e-03Click!


Activity profile for motif Maff.

activity profile for motif Maff


Sorted Z-values histogram for motif Maff

Sorted Z-values for motif Maff



Network of associatons between targets according to the STRING database.



First level regulatory network of Maff

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_136886187 7.264 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr7_-_110862944 6.502 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr15_+_3270767 5.941 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr16_-_22439719 4.800 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr19_-_57197556 4.622 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr13_-_23710714 4.319 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr9_-_111690313 3.865 ENSMUST00000035083.7
 Stac
src homology three (SH3) and cysteine rich domain
chr5_-_67815852 2.975 ENSMUST00000141443.1
 Atp8a1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
chr16_+_72663143 2.693 ENSMUST00000023600.7
 Robo1
roundabout homolog 1 (Drosophila)
chr17_-_67950908 2.689 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr1_-_136260873 2.647 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr11_+_82101836 2.619 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr15_-_33687840 2.576 ENSMUST00000042021.3
 Tspyl5
testis-specific protein, Y-encoded-like 5
chr5_+_104435112 2.341 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr3_+_109573907 2.213 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr19_+_26753588 1.930 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_+_102421518 1.926 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr3_+_65109343 1.831 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr1_+_75382114 1.747 ENSMUST00000113590.1
ENSMUST00000148515.1
 Speg

SPEG complex locus

chr18_+_32377176 1.727 ENSMUST00000091967.5
ENSMUST00000025239.7
 Bin1

bridging integrator 1

chr7_-_64925560 1.708 ENSMUST00000149851.1
 Fam189a1
family with sequence similarity 189, member A1
chr3_-_59262825 1.618 ENSMUST00000050360.7
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr2_-_130397525 1.488 ENSMUST00000028897.7
 Cpxm1
carboxypeptidase X 1 (M14 family)
chr11_+_75651504 1.483 ENSMUST00000069057.6
 Myo1c
myosin IC
chr13_-_54749627 1.414 ENSMUST00000099506.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr5_+_140505550 1.401 ENSMUST00000043050.8
ENSMUST00000124142.1
 Chst12

carbohydrate sulfotransferase 12

chr18_+_60963517 1.354 ENSMUST00000115295.2
ENSMUST00000039904.6
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr13_-_54749849 1.324 ENSMUST00000135343.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr1_-_120074023 1.273 ENSMUST00000056089.7
 Tmem37
transmembrane protein 37
chr5_+_106964319 1.194 ENSMUST00000031221.5
ENSMUST00000117196.2
ENSMUST00000076467.6
 Cdc7


cell division cycle 7 (S. cerevisiae)


chr1_+_136017967 1.174 ENSMUST00000063719.8
ENSMUST00000118832.1
 Tmem9

transmembrane protein 9

chr1_+_136018062 1.106 ENSMUST00000117950.1
 Tmem9
transmembrane protein 9
chr17_-_25570678 1.081 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr18_-_33463615 1.014 ENSMUST00000051087.8
 Nrep
neuronal regeneration related protein
chr7_+_16944645 1.004 ENSMUST00000094807.5
 Pnmal2
PNMA-like 2
chr18_-_33463747 0.928 ENSMUST00000171533.1
 Nrep
neuronal regeneration related protein
chr7_-_100964371 0.893 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr9_+_65214690 0.850 ENSMUST00000069000.7
 Parp16
poly (ADP-ribose) polymerase family, member 16
chr6_+_30401866 0.844 ENSMUST00000068240.6
ENSMUST00000068259.6
 Klhdc10

kelch domain containing 10

chr19_-_4042165 0.822 ENSMUST00000042700.9
 Gstp2
glutathione S-transferase, pi 2
chr3_-_108044801 0.815 ENSMUST00000178808.1
ENSMUST00000106670.1
ENSMUST00000029489.8
 Gstm4


glutathione S-transferase, mu 4


chr1_-_88205674 0.762 ENSMUST00000119972.2
 Dnajb3
DnaJ (Hsp40) homolog, subfamily B, member 3
chr18_-_33464007 0.739 ENSMUST00000168890.1
 Nrep
neuronal regeneration related protein
chr19_+_56722372 0.725 ENSMUST00000038949.4
 Adrb1
adrenergic receptor, beta 1
chr6_+_83795022 0.706 ENSMUST00000113851.1
 Nagk
N-acetylglucosamine kinase
chr11_-_109473598 0.698 ENSMUST00000070152.5
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr13_+_66932802 0.667 ENSMUST00000021990.3
 Ptdss1
phosphatidylserine synthase 1
chr6_+_83794974 0.613 ENSMUST00000037376.7
 Nagk
N-acetylglucosamine kinase
chr10_+_26078255 0.558 ENSMUST00000041011.3
 Gm9767
predicted gene 9767
chr2_+_121867083 0.547 ENSMUST00000089912.5
ENSMUST00000089915.3
 Casc4

cancer susceptibility candidate 4

chr8_+_25532125 0.508 ENSMUST00000167764.1
 Fgfr1
fibroblast growth factor receptor 1
chr4_-_143299463 0.496 ENSMUST00000119654.1
 Pdpn
podoplanin
chr2_+_121866918 0.483 ENSMUST00000078752.3
ENSMUST00000110586.3
 Casc4

cancer susceptibility candidate 4

chrX_+_93675088 0.482 ENSMUST00000045898.3
 Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr13_+_48261427 0.479 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr14_+_118787894 0.468 ENSMUST00000047761.6
ENSMUST00000071546.7
 Cldn10

claudin 10

chr15_-_78572754 0.418 ENSMUST00000043214.6
 Rac2
RAS-related C3 botulinum substrate 2
chr18_+_33464163 0.407 ENSMUST00000097634.3
 Gm10549
predicted gene 10549
chr19_+_58728887 0.390 ENSMUST00000048644.5
 Pnliprp1
pancreatic lipase related protein 1
chr12_+_35047180 0.377 ENSMUST00000048519.9
ENSMUST00000163677.1
 Snx13

sorting nexin 13

chr4_-_143299498 0.354 ENSMUST00000030317.7
 Pdpn
podoplanin
chr9_-_122310921 0.320 ENSMUST00000180685.1
 Gm26797
predicted gene, 26797
chr4_-_139352298 0.304 ENSMUST00000030513.6
ENSMUST00000155257.1
 Mrto4

MRT4, mRNA turnover 4, homolog (S. cerevisiae)

chr7_-_4684963 0.287 ENSMUST00000079970.4
 Hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr5_-_135251209 0.213 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr11_-_116086929 0.211 ENSMUST00000074628.6
ENSMUST00000106444.3
 Wbp2

WW domain binding protein 2

chr10_-_88605017 0.197 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr9_+_45838572 0.186 ENSMUST00000078111.4
ENSMUST00000034591.4
 Bace1

beta-site APP cleaving enzyme 1

chr4_+_139352587 0.119 ENSMUST00000147999.1
ENSMUST00000042096.7
ENSMUST00000179784.1
ENSMUST00000082262.7
 Ubr4
Emc1


ubiquitin protein ligase E3 component n-recognin 4
ER membrane protein complex subunit 1


chr19_+_8929628 0.115 ENSMUST00000096241.4
 Eml3
echinoderm microtubule associated protein like 3
chr4_-_139352538 0.112 ENSMUST00000102503.3
 Mrto4
MRT4, mRNA turnover 4, homolog (S. cerevisiae)
chr11_+_4883186 0.083 ENSMUST00000139737.1
 Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr14_-_37135310 0.064 ENSMUST00000165649.2
 Ghitm
growth hormone inducible transmembrane protein
chr7_+_139214661 0.053 ENSMUST00000135509.1
 Lrrc27
leucine rich repeat containing 27
chr15_-_25413752 0.045 ENSMUST00000058845.7
 Basp1
brain abundant, membrane attached signal protein 1
chr5_+_7179299 0.032 ENSMUST00000179460.1
 Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:0002725 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of T cell cytokine production(GO:0002725)
1.0 4.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.9 2.7 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.9 2.6 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.7 2.7 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.7 6.5 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.6 2.3 GO:0035937 androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.5 1.6 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.5 1.4 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.4 3.0 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.4 1.1 GO:0072034 renal vesicle induction(GO:0072034)
0.3 7.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 0.9 GO:0030321 transepithelial chloride transport(GO:0030321)
0.3 1.5 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2 0.7 GO:1900133 renin secretion into blood stream(GO:0002001) regulation of renin secretion into blood stream(GO:1900133)
0.2 1.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 0.8 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.2 1.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.2 1.3 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.2 0.8 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.2 0.5 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.2 0.7 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 1.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.7 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.1 1.8 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 0.5 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.1 3.8 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 1.4 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 0.8 GO:0018916 nitrobenzene metabolic process(GO:0018916)
0.1 2.2 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.1 0.2 GO:1990523 bone regeneration(GO:1990523)
0.1 0.4 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.0 0.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.2 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 2.6 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 2.4 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015)
0.0 4.6 GO:0007411 axon guidance(GO:0007411)
0.0 1.7 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.3 GO:1990357 terminal web(GO:1990357)
0.5 1.5 GO:0045160 myosin I complex(GO:0045160)
0.5 1.4 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.3 0.8 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 1.8 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.7 GO:0043196 varicosity(GO:0043196)
0.1 1.9 GO:0071564 npBAF complex(GO:0071564)
0.1 7.3 GO:0005581 collagen trimer(GO:0005581)
0.1 0.8 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 2.7 GO:0030673 axolemma(GO:0030673)
0.1 1.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 3.8 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0005859 muscle myosin complex(GO:0005859) myosin II complex(GO:0016460)
0.0 4.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.8 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 1.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.3 GO:0005770 late endosome(GO:0005770)
0.0 3.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 3.2 GO:0045177 apical part of cell(GO:0045177)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.6 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.5 4.3 GO:0039706 co-receptor binding(GO:0039706)
0.4 1.3 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.4 6.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 2.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.4 1.4 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.3 2.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 0.7 GO:0051379 epinephrine binding(GO:0051379)
0.1 3.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.8 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 1.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.5 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.8 GO:0015250 water channel activity(GO:0015250)
0.1 2.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.7 GO:0048156 tau protein binding(GO:0048156)
0.1 1.6 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 1.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 2.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 2.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 2.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 2.9 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 1.3 GO:0005262 calcium channel activity(GO:0005262)
0.0 1.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.2 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 2.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 7.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.5 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.4 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.7 6.5 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.3 2.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.2 2.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.2 4.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 3.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.4 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.6 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.1 0.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 0.5 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 1.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.2 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 2.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions