Motif ID: Max_Mycn

Z-value: 1.685

Transcription factors associated with Max_Mycn:

Gene SymbolEntrez IDGene Name
Max ENSMUSG00000059436.6 Max
Mycn ENSMUSG00000037169.8 Mycn

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mycnmm10_v2_chr12_-_12941827_129419140.676.9e-06Click!
Maxmm10_v2_chr12_-_76962178_769622480.632.9e-05Click!


Activity profile for motif Max_Mycn.

activity profile for motif Max_Mycn


Sorted Z-values histogram for motif Max_Mycn

Sorted Z-values for motif Max_Mycn



Network of associatons between targets according to the STRING database.



First level regulatory network of Max_Mycn

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_44788016 12.565 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr8_+_48109949 9.267 ENSMUST00000170263.2
ENSMUST00000033966.6
 Dctd

dCMP deaminase

chr17_-_26201363 8.103 ENSMUST00000121959.1
 Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr4_+_148591482 7.705 ENSMUST00000006611.8
 Srm
spermidine synthase
chr9_-_121495678 7.541 ENSMUST00000035120.4
 Cck
cholecystokinin
chr15_+_44787746 7.411 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr8_+_48110156 7.242 ENSMUST00000174379.1
 Dctd
dCMP deaminase
chr19_+_43440404 6.376 ENSMUST00000165311.1
 Cnnm1
cyclin M1
chr15_+_60822947 6.014 ENSMUST00000180730.1
 9930014A18Rik
RIKEN cDNA 9930014A18 gene
chr5_-_135251209 5.067 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr8_-_122551316 4.821 ENSMUST00000067252.7
 Piezo1
piezo-type mechanosensitive ion channel component 1
chr8_-_105938384 4.814 ENSMUST00000034369.8
 Psmb10
proteasome (prosome, macropain) subunit, beta type 10
chr13_-_47014814 4.750 ENSMUST00000052747.2
 Nhlrc1
NHL repeat containing 1
chr1_+_71557149 4.585 ENSMUST00000027384.5
 Atic
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr11_-_6065737 4.395 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr4_+_103619580 4.336 ENSMUST00000106827.1
 Dab1
disabled 1
chr9_+_34486125 4.310 ENSMUST00000115148.2
ENSMUST00000183580.1
 Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr1_-_38836090 4.213 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr1_+_55088132 4.212 ENSMUST00000075242.6
 Hspe1
heat shock protein 1 (chaperonin 10)
chr6_-_91473361 4.106 ENSMUST00000040835.7
 Chchd4
coiled-coil-helix-coiled-coil-helix domain containing 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 632 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.5 16.5 GO:0006226 dUMP biosynthetic process(GO:0006226)
0.7 13.8 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466)
0.4 10.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 9.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
1.3 9.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.5 9.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.5 8.6 GO:0097154 GABAergic neuron differentiation(GO:0097154)
2.7 8.2 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
1.6 8.2 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.4 8.1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.3 8.0 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
1.6 7.8 GO:0008355 olfactory learning(GO:0008355)
1.9 7.7 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.1 7.6 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.8 7.5 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.2 7.1 GO:0018345 protein palmitoylation(GO:0018345)
1.3 6.5 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
2.1 6.4 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
1.3 6.4 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 6.4 GO:0006414 translational elongation(GO:0006414)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 276 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 16.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.6 13.2 GO:0097433 dense body(GO:0097433)
0.2 11.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.8 10.9 GO:0043203 axon hillock(GO:0043203)
0.4 10.8 GO:0030686 90S preribosome(GO:0030686)
0.9 10.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 9.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 9.7 GO:0044298 cell body membrane(GO:0044298)
0.0 9.7 GO:0097060 synaptic membrane(GO:0097060)
0.0 9.1 GO:0000139 Golgi membrane(GO:0000139)
0.1 8.6 GO:0005903 brush border(GO:0005903)
0.1 8.6 GO:0031965 nuclear membrane(GO:0031965)
0.8 7.8 GO:0070545 PeBoW complex(GO:0070545)
0.4 7.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 7.3 GO:0043198 dendritic shaft(GO:0043198)
0.1 7.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 7.0 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.3 6.2 GO:0098984 neuron to neuron synapse(GO:0098984)
0.1 6.2 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 436 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 29.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 19.9 GO:0003924 GTPase activity(GO:0003924)
0.6 17.3 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.6 15.9 GO:0017075 syntaxin-1 binding(GO:0017075)
1.7 11.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.6 11.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.6 10.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.7 9.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.4 8.3 GO:0043274 phospholipase binding(GO:0043274)
0.5 8.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 8.0 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
1.3 7.6 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.3 7.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 7.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 7.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.9 7.0 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
1.1 6.8 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
1.0 6.7 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.2 6.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 6.5 GO:0015485 cholesterol binding(GO:0015485)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 16.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 10.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 10.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 9.1 PID_MTOR_4PATHWAY mTOR signaling pathway
0.5 8.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.5 8.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 8.3 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 7.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.3 6.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 6.5 PID_P53_REGULATION_PATHWAY p53 pathway
0.2 5.9 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 5.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.3 5.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.1 PID_MYC_PATHWAY C-MYC pathway
0.1 3.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.8 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 2.7 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 33.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.9 20.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 17.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 16.9 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.4 11.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.7 10.7 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.4 10.5 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 10.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 8.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 8.5 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.4 8.2 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 7.8 REACTOME_TRANSLATION Genes involved in Translation
0.6 7.6 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 7.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.3 7.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.5 7.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 6.2 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM Genes involved in Integration of energy metabolism
0.3 6.1 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 6.0 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.3 5.8 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC