Motif ID: Maz_Zfp281

Z-value: 1.245

Transcription factors associated with Maz_Zfp281:

Gene SymbolEntrez IDGene Name
Maz ENSMUSG00000030678.6 Maz
Zfp281 ENSMUSG00000041483.8 Zfp281

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp281mm10_v2_chr1_+_136624901_1366249490.429.6e-03Click!
Mazmm10_v2_chr7_-_127026479_1270264960.261.3e-01Click!


Activity profile for motif Maz_Zfp281.

activity profile for motif Maz_Zfp281


Sorted Z-values histogram for motif Maz_Zfp281

Sorted Z-values for motif Maz_Zfp281



Network of associatons between targets according to the STRING database.



First level regulatory network of Maz_Zfp281

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_138847579 15.565 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr14_-_98169542 9.398 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_-_34372004 9.063 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chr18_+_64340225 8.108 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr4_+_97777780 7.973 ENSMUST00000107062.2
ENSMUST00000052018.5
ENSMUST00000107057.1
 Nfia


nuclear factor I/A


chr1_-_138848576 7.840 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr11_-_88718223 7.489 ENSMUST00000107909.1
 Msi2
musashi RNA-binding protein 2
chr4_+_97777606 7.460 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr16_+_84774123 7.232 ENSMUST00000114195.1
 Jam2
junction adhesion molecule 2
chr18_+_35829798 7.132 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr6_+_134929089 6.981 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr4_-_97778042 6.944 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr9_+_118478851 6.615 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr3_+_131110350 6.369 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr15_+_32244801 6.084 ENSMUST00000067458.6
 Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr2_+_38339258 5.729 ENSMUST00000143783.2
 Lhx2
LIM homeobox protein 2
chr9_+_118478344 5.710 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr19_+_59458372 5.524 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr6_+_120666388 5.516 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr15_+_57694651 5.462 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,101 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.9 29.6 GO:0035262 gonad morphogenesis(GO:0035262)
0.8 21.9 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
1.0 18.0 GO:0010715 regulation of extracellular matrix disassembly(GO:0010715)
5.7 17.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.0 15.7 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
2.4 14.2 GO:0070094 positive regulation of glucagon secretion(GO:0070094)
1.7 13.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
4.4 13.3 GO:0030421 defecation(GO:0030421)
1.1 11.7 GO:0072189 ureter development(GO:0072189)
1.3 11.3 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
3.5 10.5 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
1.1 10.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.6 9.5 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
3.1 9.2 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
1.1 9.1 GO:2001198 regulation of dendritic cell differentiation(GO:2001198)
1.0 9.0 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
2.9 8.6 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.3 8.6 GO:0051310 metaphase plate congression(GO:0051310)
0.9 8.4 GO:0010587 miRNA catabolic process(GO:0010587)
2.6 7.9 GO:0071898 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 310 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 117.3 GO:0005634 nucleus(GO:0005634)
0.1 93.4 GO:0005654 nucleoplasm(GO:0005654)
0.4 26.5 GO:0005844 polysome(GO:0005844)
0.1 22.4 GO:0005667 transcription factor complex(GO:0005667)
0.2 21.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 16.5 GO:0032993 protein-DNA complex(GO:0032993)
1.3 14.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.7 14.5 GO:0010369 chromocenter(GO:0010369)
0.1 12.7 GO:0005681 spliceosomal complex(GO:0005681)
0.2 10.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 10.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.7 9.2 GO:0043219 lateral loop(GO:0043219)
0.5 9.1 GO:0097470 ribbon synapse(GO:0097470)
0.1 8.9 GO:0000793 condensed chromosome(GO:0000793)
0.1 8.7 GO:0000775 chromosome, centromeric region(GO:0000775)
0.7 8.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 8.0 GO:0000228 nuclear chromosome(GO:0000228)
0.4 7.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
1.3 7.6 GO:0031262 Ndc80 complex(GO:0031262)
1.5 7.3 GO:0097149 centralspindlin complex(GO:0097149)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 537 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 70.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 45.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.4 43.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 36.1 GO:0003677 DNA binding(GO:0003677)
0.2 24.8 GO:0001047 core promoter binding(GO:0001047)
0.4 23.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 19.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.4 17.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.7 15.9 GO:0008266 poly(U) RNA binding(GO:0008266)
0.9 14.8 GO:0003680 AT DNA binding(GO:0003680)
0.3 14.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.4 13.2 GO:0070888 E-box binding(GO:0070888)
1.3 11.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 11.1 GO:0003682 chromatin binding(GO:0003682)
1.4 10.8 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.4 10.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.2 9.9 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.8 9.8 GO:0050693 LBD domain binding(GO:0050693)
0.3 9.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.5 9.7 GO:0001848 complement binding(GO:0001848)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 27.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 26.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 25.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.5 23.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.4 19.7 PID_PLK1_PATHWAY PLK1 signaling events
1.3 17.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 17.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.4 16.8 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.3 16.4 PID_IL12_2PATHWAY IL12-mediated signaling events
0.5 15.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 11.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 11.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.3 11.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.5 9.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 8.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 8.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 6.8 PID_CDC42_PATHWAY CDC42 signaling events
0.7 6.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 6.3 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 5.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 35.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 29.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5 18.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.5 15.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 14.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.4 10.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.8 9.9 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.5 9.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.4 9.2 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.6 9.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.8 8.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 8.1 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.6 6.9 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 6.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.8 6.5 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 6.5 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.8 6.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.4 6.1 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.3 5.8 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 5.6 REACTOME_KINESINS Genes involved in Kinesins