Motif ID: Mbd2

Z-value: 1.210


Transcription factors associated with Mbd2:

Gene SymbolEntrez IDGene Name
Mbd2 ENSMUSG00000024513.10 Mbd2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mbd2mm10_v2_chr18_+_70568189_70568398-0.105.5e-01Click!


Activity profile for motif Mbd2.

activity profile for motif Mbd2


Sorted Z-values histogram for motif Mbd2

Sorted Z-values for motif Mbd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mbd2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_108003414 8.187 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr5_+_30588078 7.282 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr11_-_75796048 5.649 ENSMUST00000021209.7
 Doc2b
double C2, beta
chr14_-_39472825 5.253 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr1_+_75375271 4.797 ENSMUST00000087122.5
 Speg
SPEG complex locus
chr19_+_56722372 4.454 ENSMUST00000038949.4
 Adrb1
adrenergic receptor, beta 1
chr5_+_37028329 4.315 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr18_-_58209926 4.095 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr6_-_126740151 4.078 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr13_+_110395041 3.886 ENSMUST00000022212.7
 Plk2
polo-like kinase 2
chr13_+_46418266 3.776 ENSMUST00000037923.3
 Rbm24
RNA binding motif protein 24
chr4_-_120747248 3.755 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr11_+_7063423 3.481 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr5_-_115194283 3.305 ENSMUST00000112113.1
 Cabp1
calcium binding protein 1
chr7_+_29303938 3.199 ENSMUST00000108231.1
 Dpf1
D4, zinc and double PHD fingers family 1
chr7_-_126082406 3.159 ENSMUST00000073935.5
 Gsg1l
GSG1-like
chr7_+_29303958 3.079 ENSMUST00000049977.6
 Dpf1
D4, zinc and double PHD fingers family 1
chr7_-_74554474 3.025 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr13_-_52981027 3.024 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr12_-_108003594 2.993 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 11.2 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
1.0 9.1 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.7 7.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.3 5.6 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
1.6 4.8 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
1.2 4.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
1.5 4.5 GO:1900133 renin secretion into blood stream(GO:0002001) regulation of renin secretion into blood stream(GO:1900133)
0.2 4.3 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.2 4.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.8 4.1 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.3 3.9 GO:0032486 Rap protein signal transduction(GO:0032486)
0.9 3.8 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
1.2 3.7 GO:0060596 mammary placode formation(GO:0060596)
0.2 3.5 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 3.5 GO:0050890 cognition(GO:0050890)
0.7 3.4 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.0 3.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 3.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 3.0 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.2 2.7 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.9 GO:0005615 extracellular space(GO:0005615)
0.9 9.1 GO:0045298 tubulin complex(GO:0045298)
0.0 9.0 GO:0000139 Golgi membrane(GO:0000139)
0.1 7.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 6.4 GO:0060076 excitatory synapse(GO:0060076)
0.3 6.3 GO:0071565 nBAF complex(GO:0071565)
0.1 5.6 GO:0031201 SNARE complex(GO:0031201)
0.0 4.6 GO:0005769 early endosome(GO:0005769)
0.3 4.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 4.1 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 3.9 GO:0005814 centriole(GO:0005814)
0.1 3.6 GO:0009925 basal plasma membrane(GO:0009925)
0.2 3.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.8 3.4 GO:1990032 parallel fiber(GO:1990032)
0.1 3.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 3.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 3.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.9 GO:0034399 nuclear periphery(GO:0034399)
0.1 2.7 GO:0001741 XY body(GO:0001741)
0.1 2.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 9.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.7 7.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 5.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 5.3 GO:0045499 chemorepellent activity(GO:0045499)
0.5 4.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 4.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.9 4.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
1.5 4.5 GO:0051379 epinephrine binding(GO:0051379)
0.2 4.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 3.9 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.6 3.8 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.6 3.5 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 3.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.5 3.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.4 3.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.4 3.0 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.2 3.0 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 2.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 2.7 GO:0051087 chaperone binding(GO:0051087)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.4 5.3 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 5.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 4.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 4.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.7 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.2 3.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 3.4 PID_FGF_PATHWAY FGF signaling pathway
0.0 3.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 3.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 2.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.3 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.0 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.5 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.5 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.4 ST_GAQ_PATHWAY G alpha q Pathway
0.0 1.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.9 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.1 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 7.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.0 7.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.4 4.8 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.3 4.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 4.0 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.3 3.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.4 3.0 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 2.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.7 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 2.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 1.7 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.4 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.3 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 1.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.2 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 1.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB