Motif ID: Mecp2
Z-value: 2.881
Transcription factors associated with Mecp2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Mecp2 | ENSMUSG00000031393.10 | Mecp2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mecp2 | mm10_v2_chrX_-_74085586_74085652 | 0.21 | 2.1e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,054 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.1 | 27.4 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 1.2 | 26.7 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.7 | 26.1 | GO:0035329 | hippo signaling(GO:0035329) |
| 8.6 | 25.9 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 7.4 | 22.3 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 3.7 | 22.3 | GO:0003383 | apical constriction(GO:0003383) |
| 2.1 | 21.2 | GO:0060059 | embryonic retina morphogenesis in camera-type eye(GO:0060059) |
| 0.8 | 21.0 | GO:0035411 | catenin import into nucleus(GO:0035411) |
| 1.0 | 20.9 | GO:0021978 | telencephalon regionalization(GO:0021978) |
| 1.2 | 18.6 | GO:0048617 | embryonic foregut morphogenesis(GO:0048617) |
| 1.3 | 17.9 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 4.5 | 17.8 | GO:0021603 | cranial nerve formation(GO:0021603) |
| 4.4 | 17.5 | GO:1902724 | positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 1.5 | 17.5 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 2.9 | 17.4 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 1.7 | 17.0 | GO:2000781 | positive regulation of double-strand break repair(GO:2000781) |
| 3.4 | 16.9 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 1.4 | 15.9 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 2.0 | 15.7 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 2.2 | 15.4 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 328 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 221.4 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.0 | 166.3 | GO:0005634 | nucleus(GO:0005634) |
| 0.5 | 76.5 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.2 | 52.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.6 | 47.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 33.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.4 | 29.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.4 | 24.5 | GO:0005844 | polysome(GO:0005844) |
| 2.3 | 22.7 | GO:0000796 | condensin complex(GO:0000796) |
| 2.8 | 22.2 | GO:0033269 | internode region of axon(GO:0033269) |
| 3.9 | 19.7 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.4 | 17.7 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.7 | 17.6 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.2 | 17.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 17.2 | GO:0005813 | centrosome(GO:0005813) |
| 0.8 | 15.8 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 1.4 | 15.6 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.6 | 15.5 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.9 | 14.8 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.2 | 14.6 | GO:0030175 | filopodium(GO:0030175) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 525 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 167.1 | GO:0003677 | DNA binding(GO:0003677) |
| 0.5 | 154.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.4 | 56.7 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
| 0.3 | 42.5 | GO:0042393 | histone binding(GO:0042393) |
| 0.3 | 36.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.5 | 31.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.6 | 28.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 1.9 | 22.8 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.7 | 22.0 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 2.3 | 20.4 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.6 | 19.9 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.8 | 19.7 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.1 | 19.4 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.5 | 18.6 | GO:0030332 | cyclin binding(GO:0030332) |
| 1.9 | 17.5 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 2.2 | 17.4 | GO:0046790 | virion binding(GO:0046790) |
| 0.9 | 17.0 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.3 | 16.2 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 1.7 | 15.5 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.5 | 15.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 89 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 80.4 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 1.1 | 44.0 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.5 | 33.3 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.5 | 31.0 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.8 | 28.2 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 1.8 | 25.4 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.4 | 25.4 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.5 | 23.9 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 1.3 | 23.4 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.6 | 23.3 | PID_FAS_PATHWAY | FAS (CD95) signaling pathway |
| 0.7 | 22.8 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.7 | 22.2 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.5 | 22.2 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.7 | 21.5 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.4 | 20.3 | PID_INTEGRIN1_PATHWAY | Beta1 integrin cell surface interactions |
| 0.6 | 19.1 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 1.9 | 17.3 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.7 | 13.3 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.3 | 13.2 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.6 | 13.0 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 140 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 58.0 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.2 | 36.8 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 1.3 | 28.2 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.8 | 27.5 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.9 | 26.7 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.9 | 24.3 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.7 | 23.4 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 1.4 | 22.2 | REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 1.8 | 21.8 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 1.1 | 21.7 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.7 | 20.0 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 1.9 | 18.7 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 1.7 | 17.5 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.9 | 17.3 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.3 | 17.2 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.5 | 16.2 | REACTOME_PIP3_ACTIVATES_AKT_SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.1 | 16.1 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.7 | 14.5 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.5 | 14.3 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.4 | 13.7 | REACTOME_SIGNALING_BY_ERBB4 | Genes involved in Signaling by ERBB4 |
