Motif ID: Mef2b

Z-value: 0.664


Transcription factors associated with Mef2b:

Gene SymbolEntrez IDGene Name
Mef2b ENSMUSG00000079033.3 Mef2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2bmm10_v2_chr8_+_70152754_701527810.076.6e-01Click!


Activity profile for motif Mef2b.

activity profile for motif Mef2b


Sorted Z-values histogram for motif Mef2b

Sorted Z-values for motif Mef2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 179 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_24985840 3.506 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr6_-_23248264 3.150 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_-_128953303 3.080 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chrY_-_1286563 3.072 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr6_+_137410721 2.958 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr13_+_5861489 2.862 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr2_-_172043466 2.445 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr18_+_60963517 2.304 ENSMUST00000115295.2
ENSMUST00000039904.6
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr9_+_34904913 2.202 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr13_-_113663670 2.186 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr4_+_141368116 1.791 ENSMUST00000006380.4
 Fam131c
family with sequence similarity 131, member C
chr9_-_110742577 1.788 ENSMUST00000006005.7
 Pth1r
parathyroid hormone 1 receptor
chr2_-_79908428 1.749 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr7_-_103843154 1.737 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr3_+_96596628 1.736 ENSMUST00000058943.7
 Ankrd34a
ankyrin repeat domain 34A
chr2_+_118663235 1.647 ENSMUST00000099557.3
 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr2_-_57124003 1.576 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr3_+_68584154 1.518 ENSMUST00000182997.1
 Schip1
schwannomin interacting protein 1
chr7_-_142899985 1.483 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr18_+_76059458 1.482 ENSMUST00000167921.1
 Zbtb7c
zinc finger and BTB domain containing 7C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.5 3.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 3.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 3.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.6 3.0 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.2 2.3 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.4 2.2 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 1.9 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 1.8 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.3 1.7 GO:0015671 oxygen transport(GO:0015671)
0.0 1.7 GO:0007612 learning(GO:0007612)
0.4 1.6 GO:0051866 general adaptation syndrome(GO:0051866)
0.4 1.5 GO:0042414 epinephrine metabolic process(GO:0042414)
0.3 1.5 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 1.5 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 1.5 GO:0001553 luteinization(GO:0001553)
0.0 1.4 GO:0055013 cardiac muscle cell development(GO:0055013)
0.1 1.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.3 1.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 1.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0001650 fibrillar center(GO:0001650)
0.0 3.1 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 3.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 2.5 GO:0043198 dendritic shaft(GO:0043198)
0.8 2.3 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.0 2.0 GO:0031526 brush border membrane(GO:0031526)
0.1 1.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 1.7 GO:0005833 hemoglobin complex(GO:0005833)
0.5 1.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.4 GO:0043194 axon initial segment(GO:0043194)
0.1 1.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 0.8 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.8 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 0.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.1 0.6 GO:0090537 CERF complex(GO:0090537)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.6 4.1 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 3.1 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 3.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 2.6 GO:0030165 PDZ domain binding(GO:0030165)
0.2 2.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 2.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.8 GO:0017046 peptide hormone binding(GO:0017046)
0.4 1.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.3 1.5 GO:0035240 dopamine binding(GO:0035240)
0.2 1.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.3 1.3 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 1.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 1.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.4 1.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.3 1.0 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.3 1.0 GO:0004111 creatine kinase activity(GO:0004111)
0.0 1.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 1.0 GO:0048365 Rac GTPase binding(GO:0048365)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 3.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 2.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.6 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.9 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.3 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 3.5 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 2.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.8 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.7 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.6 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME_TELOMERE_MAINTENANCE Genes involved in Telomere Maintenance
0.0 0.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.2 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism