Motif ID: Mef2b

Z-value: 0.664


Transcription factors associated with Mef2b:

Gene SymbolEntrez IDGene Name
Mef2b ENSMUSG00000079033.3 Mef2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2bmm10_v2_chr8_+_70152754_701527810.076.6e-01Click!


Activity profile for motif Mef2b.

activity profile for motif Mef2b


Sorted Z-values histogram for motif Mef2b

Sorted Z-values for motif Mef2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2b

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_24985840 3.506 ENSMUST00000075081.6
1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr6_-_23248264 3.150 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr5_-_128953303 3.080 ENSMUST00000111346.1
Rimbp2
RIMS binding protein 2
chrY_-_1286563 3.072 ENSMUST00000091190.5
Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr6_+_137410721 2.958 ENSMUST00000167002.1
Ptpro
protein tyrosine phosphatase, receptor type, O
chr13_+_5861489 2.862 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr2_-_172043466 2.445 ENSMUST00000087950.3
Cbln4
cerebellin 4 precursor protein
chr18_+_60963517 2.304 ENSMUST00000115295.2
ENSMUST00000039904.6
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr9_+_34904913 2.202 ENSMUST00000045091.6
Kirrel3
kin of IRRE like 3 (Drosophila)
chr13_-_113663670 2.186 ENSMUST00000054650.4
Hspb3
heat shock protein 3
chr4_+_141368116 1.791 ENSMUST00000006380.4
Fam131c
family with sequence similarity 131, member C
chr9_-_110742577 1.788 ENSMUST00000006005.7
Pth1r
parathyroid hormone 1 receptor
chr2_-_79908428 1.749 ENSMUST00000102652.3
ENSMUST00000102651.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr7_-_103843154 1.737 ENSMUST00000063957.4
Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr3_+_96596628 1.736 ENSMUST00000058943.7
Ankrd34a
ankyrin repeat domain 34A
chr2_+_118663235 1.647 ENSMUST00000099557.3
Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr2_-_57124003 1.576 ENSMUST00000112629.1
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr3_+_68584154 1.518 ENSMUST00000182997.1
Schip1
schwannomin interacting protein 1
chr7_-_142899985 1.483 ENSMUST00000000219.3
Th
tyrosine hydroxylase
chr18_+_76059458 1.482 ENSMUST00000167921.1
Zbtb7c
zinc finger and BTB domain containing 7C
chr3_-_158562199 1.376 ENSMUST00000106044.1
Lrrc7
leucine rich repeat containing 7
chr2_-_79908389 1.372 ENSMUST00000090756.4
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr1_+_75375271 1.358 ENSMUST00000087122.5
Speg
SPEG complex locus
chr3_+_146852359 1.273 ENSMUST00000038090.5
ENSMUST00000170055.1
Ttll7

tubulin tyrosine ligase-like family, member 7

chr6_-_136171722 1.187 ENSMUST00000053880.6
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chrX_-_48208870 1.179 ENSMUST00000088935.3
Zdhhc9
zinc finger, DHHC domain containing 9
chr8_+_31089471 1.086 ENSMUST00000036631.7
ENSMUST00000170204.1
Dusp26

dual specificity phosphatase 26 (putative)

chr12_+_69241832 1.046 ENSMUST00000063445.6
Klhdc1
kelch domain containing 1
chr18_-_25753852 1.044 ENSMUST00000025117.6
ENSMUST00000115816.2
Celf4

CUGBP, Elav-like family member 4

chr12_-_111672290 1.006 ENSMUST00000001304.7
Ckb
creatine kinase, brain
chr2_-_80128834 0.997 ENSMUST00000102654.4
ENSMUST00000102655.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr7_+_91090697 0.994 ENSMUST00000107196.2
Dlg2
discs, large homolog 2 (Drosophila)
chr3_-_113574758 0.977 ENSMUST00000106540.1
Amy1
amylase 1, salivary
chrX_+_142825698 0.955 ENSMUST00000112888.1
Tmem164
transmembrane protein 164
chr2_+_164486856 0.939 ENSMUST00000109349.2
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr7_+_91090728 0.938 ENSMUST00000074273.3
Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_81862674 0.936 ENSMUST00000119543.1
Tm6sf1
transmembrane 6 superfamily member 1
chr4_-_9643638 0.903 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
Asph




aspartate-beta-hydroxylase




chr10_+_90576872 0.875 ENSMUST00000182550.1
ENSMUST00000099364.5
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr4_+_5724304 0.873 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr9_-_110654161 0.852 ENSMUST00000133191.1
ENSMUST00000167320.1
Nbeal2

neurobeachin-like 2

chrX_-_165004829 0.835 ENSMUST00000114890.2
Gm17604
predicted gene, 17604
chr11_-_83649349 0.813 ENSMUST00000001008.5
Ccl3
chemokine (C-C motif) ligand 3
chr19_-_37176055 0.795 ENSMUST00000142973.1
ENSMUST00000154376.1
Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr6_-_136941887 0.785 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr17_+_34039437 0.783 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
Col11a2



collagen, type XI, alpha 2



chr1_+_187609028 0.778 ENSMUST00000110939.1
Esrrg
estrogen-related receptor gamma
chr6_-_136941694 0.759 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_136713444 0.749 ENSMUST00000028727.4
ENSMUST00000110098.3
Snap25

synaptosomal-associated protein 25

chr4_-_42856771 0.722 ENSMUST00000107981.1
Gm12394
predicted gene 12394
chr16_+_4968936 0.697 ENSMUST00000090457.5
4930451G09Rik
RIKEN cDNA 4930451G09 gene
chr5_+_33018816 0.694 ENSMUST00000019109.7
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr3_+_32817520 0.688 ENSMUST00000072312.5
ENSMUST00000108228.1
Usp13

ubiquitin specific peptidase 13 (isopeptidase T-3)

chr4_+_62663620 0.664 ENSMUST00000126338.1
Rgs3
regulator of G-protein signaling 3
chr1_-_191183244 0.643 ENSMUST00000027941.8
Atf3
activating transcription factor 3
chrX_-_47892502 0.600 ENSMUST00000077569.4
ENSMUST00000101616.2
ENSMUST00000088973.4
Smarca1


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1


chr16_+_95702044 0.589 ENSMUST00000023612.8
Ets2
E26 avian leukemia oncogene 2, 3' domain
chr17_-_25837082 0.581 ENSMUST00000183929.1
ENSMUST00000184865.1
ENSMUST00000026831.7
Rhbdl1


rhomboid, veinlet-like 1 (Drosophila)


chr1_-_172329261 0.581 ENSMUST00000062387.2
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr1_-_64121456 0.571 ENSMUST00000142009.1
ENSMUST00000114086.1
Klf7

Kruppel-like factor 7 (ubiquitous)

chr9_+_99629823 0.556 ENSMUST00000112886.2
Dzip1l
DAZ interacting protein 1-like
chr9_+_99629496 0.550 ENSMUST00000131095.1
ENSMUST00000078367.5
ENSMUST00000112885.2
Dzip1l


DAZ interacting protein 1-like


chr11_-_79504078 0.531 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr10_-_70592782 0.511 ENSMUST00000162251.1
Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr18_+_50030977 0.509 ENSMUST00000145726.1
ENSMUST00000128377.1
Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr13_-_23934156 0.465 ENSMUST00000052776.2
Hist1h2ba
histone cluster 1, H2ba
chr3_+_137341067 0.465 ENSMUST00000122064.1
Emcn
endomucin
chr8_+_119666498 0.461 ENSMUST00000024107.5
Wfdc1
WAP four-disulfide core domain 1
chr1_-_12991109 0.448 ENSMUST00000115403.2
ENSMUST00000115402.1
Slco5a1

solute carrier organic anion transporter family, member 5A1

chrX_+_75095854 0.438 ENSMUST00000033776.8
Dkc1
dyskeratosis congenita 1, dyskerin
chr3_-_20155069 0.436 ENSMUST00000184552.1
ENSMUST00000178328.1
Gyg

glycogenin

chr3_-_56183678 0.433 ENSMUST00000029374.6
Nbea
neurobeachin
chr6_+_48589560 0.431 ENSMUST00000181661.1
Gm5111
predicted gene 5111
chr13_+_20090500 0.409 ENSMUST00000165249.2
Elmo1
engulfment and cell motility 1
chr3_-_138143352 0.406 ENSMUST00000098580.2
Mttp
microsomal triglyceride transfer protein
chrX_+_75096039 0.406 ENSMUST00000131155.1
ENSMUST00000132000.1
Dkc1

dyskeratosis congenita 1, dyskerin

chr9_-_36797303 0.401 ENSMUST00000115086.5
Ei24
etoposide induced 2.4 mRNA
chr15_-_81843699 0.396 ENSMUST00000092020.2
Gm8444
predicted gene 8444
chr9_-_36797273 0.393 ENSMUST00000163192.3
Ei24
etoposide induced 2.4 mRNA
chr6_+_121300227 0.385 ENSMUST00000064580.7
Slc6a13
solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr5_+_21785253 0.383 ENSMUST00000030769.5
Psmc2
proteasome (prosome, macropain) 26S subunit, ATPase 2
chr10_-_128549102 0.382 ENSMUST00000176906.1
Rpl41
ribosomal protein L41
chr16_-_92400067 0.382 ENSMUST00000023672.8
Rcan1
regulator of calcineurin 1
chr1_+_171437535 0.381 ENSMUST00000043839.4
F11r
F11 receptor
chr9_-_108649349 0.381 ENSMUST00000013338.8
Arih2
ariadne homolog 2 (Drosophila)
chr10_-_128549125 0.377 ENSMUST00000177163.1
ENSMUST00000176683.1
ENSMUST00000176010.1
Rpl41


ribosomal protein L41


chr13_+_20090538 0.370 ENSMUST00000072519.5
Elmo1
engulfment and cell motility 1
chr7_-_100514800 0.367 ENSMUST00000054923.7
Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr2_+_91096744 0.366 ENSMUST00000132741.2
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_+_75655873 0.365 ENSMUST00000108431.2
Myo1c
myosin IC
chr3_+_96833218 0.363 ENSMUST00000128789.1
Pdzk1
PDZ domain containing 1
chr3_-_98814434 0.358 ENSMUST00000029463.6
Hsd3b6
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
chr8_-_46211284 0.344 ENSMUST00000034049.4
Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr16_-_93603803 0.337 ENSMUST00000023669.5
ENSMUST00000113951.2
Setd4

SET domain containing 4

chr5_-_3596071 0.330 ENSMUST00000121877.1
Rbm48
RNA binding motif protein 48
chr2_+_107290590 0.330 ENSMUST00000037012.2
Kcna4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr2_+_172440556 0.329 ENSMUST00000029005.3
Rtfdc1
replication termination factor 2 domain containing 1
chr5_-_148392810 0.324 ENSMUST00000138257.1
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr8_+_19682268 0.315 ENSMUST00000153710.1
ENSMUST00000127799.1
Gm6483

predicted gene 6483

chr16_-_56712825 0.315 ENSMUST00000136394.1
Tfg
Trk-fused gene
chr3_+_89459325 0.309 ENSMUST00000107410.1
Pmvk
phosphomevalonate kinase
chr15_+_25940846 0.309 ENSMUST00000110438.1
Fam134b
family with sequence similarity 134, member B
chr19_-_8723356 0.304 ENSMUST00000170157.1
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr3_+_137341103 0.303 ENSMUST00000119475.1
Emcn
endomucin
chr7_+_101896817 0.284 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr6_-_35539765 0.277 ENSMUST00000031866.5
Mtpn
myotrophin
chr2_-_168712853 0.276 ENSMUST00000123156.1
ENSMUST00000156555.1
Atp9a

ATPase, class II, type 9A

chr2_+_120463566 0.273 ENSMUST00000028749.7
ENSMUST00000110721.1
Capn3

calpain 3

chr4_+_156215920 0.260 ENSMUST00000105572.1
2310042D19Rik
RIKEN cDNA 2310042D19 gene
chr13_-_23369156 0.259 ENSMUST00000125328.1
ENSMUST00000145451.1
ENSMUST00000050101.2
Zfp322a


zinc finger protein 322A


chr1_-_64121389 0.225 ENSMUST00000055001.3
Klf7
Kruppel-like factor 7 (ubiquitous)
chr3_+_89459118 0.213 ENSMUST00000029564.5
Pmvk
phosphomevalonate kinase
chr5_+_8660059 0.186 ENSMUST00000047753.4
Abcb1a
ATP-binding cassette, sub-family B (MDR/TAP), member 1A
chr19_-_46969474 0.186 ENSMUST00000086961.7
Nt5c2
5'-nucleotidase, cytosolic II
chr8_-_105943382 0.183 ENSMUST00000038896.7
Lcat
lecithin cholesterol acyltransferase
chr17_-_14694223 0.179 ENSMUST00000170872.1
Thbs2
thrombospondin 2
chrX_+_159303266 0.179 ENSMUST00000112491.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr7_+_140763739 0.177 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr6_+_126939957 0.176 ENSMUST00000032497.3
D6Wsu163e
DNA segment, Chr 6, Wayne State University 163, expressed
chr16_-_17201490 0.173 ENSMUST00000090192.5
ENSMUST00000115700.1
Ube2l3

ubiquitin-conjugating enzyme E2L 3

chr5_+_25759987 0.168 ENSMUST00000128727.1
ENSMUST00000088244.4
Actr3b

ARP3 actin-related protein 3B

chr8_-_67515606 0.168 ENSMUST00000032981.5
Gm9755
predicted pseudogene 9755
chr19_+_21272276 0.166 ENSMUST00000025659.4
Zfand5
zinc finger, AN1-type domain 5
chr3_-_150073620 0.164 ENSMUST00000057740.5
Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr18_+_37513652 0.160 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr5_-_122614445 0.157 ENSMUST00000127220.1
ENSMUST00000031426.7
Ift81

intraflagellar transport 81

chr7_+_99594605 0.156 ENSMUST00000162290.1
Arrb1
arrestin, beta 1
chr13_-_67081503 0.151 ENSMUST00000109742.3
Zfp708
zinc finger protein 708
chr7_+_30121915 0.145 ENSMUST00000098596.3
ENSMUST00000153792.1
Zfp382

zinc finger protein 382

chr8_+_3500451 0.137 ENSMUST00000004683.6
ENSMUST00000160338.1
Mcoln1

mucolipin 1

chrX_-_93832106 0.136 ENSMUST00000045748.6
Pdk3
pyruvate dehydrogenase kinase, isoenzyme 3
chr17_+_74489492 0.135 ENSMUST00000024873.6
Yipf4
Yip1 domain family, member 4
chr8_-_95853501 0.132 ENSMUST00000040481.3
Slc38a7
solute carrier family 38, member 7
chr1_-_64122256 0.131 ENSMUST00000135075.1
Klf7
Kruppel-like factor 7 (ubiquitous)
chr4_-_95052188 0.128 ENSMUST00000107094.1
Jun
Jun oncogene
chrX_+_10717451 0.125 ENSMUST00000156321.1
Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr11_+_54304180 0.124 ENSMUST00000108904.3
ENSMUST00000108905.3
Acsl6

acyl-CoA synthetase long-chain family member 6

chr11_-_51688614 0.121 ENSMUST00000007921.2
0610009B22Rik
RIKEN cDNA 0610009B22 gene
chr14_-_61439831 0.117 ENSMUST00000022496.7
Kpna3
karyopherin (importin) alpha 3
chr5_-_3893907 0.115 ENSMUST00000117463.1
ENSMUST00000044746.4
Mterf

mitochondrial transcription termination factor

chr19_+_8723478 0.106 ENSMUST00000180819.1
ENSMUST00000181422.1
Snhg1

small nucleolar RNA host gene (non-protein coding) 1

chr7_-_144738520 0.102 ENSMUST00000118556.2
ENSMUST00000033393.8
Ano1

anoctamin 1, calcium activated chloride channel

chr9_-_123862023 0.101 ENSMUST00000182350.1
ENSMUST00000078755.2
Xcr1

chemokine (C motif) receptor 1

chr2_+_147012996 0.100 ENSMUST00000028921.5
Xrn2
5'-3' exoribonuclease 2
chr5_+_140419248 0.096 ENSMUST00000100507.3
Eif3b
eukaryotic translation initiation factor 3, subunit B
chr6_+_116650674 0.094 ENSMUST00000067354.5
ENSMUST00000178241.1
8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr11_+_105178765 0.094 ENSMUST00000106939.2
Tlk2
tousled-like kinase 2 (Arabidopsis)
chr4_+_43493345 0.093 ENSMUST00000030181.5
ENSMUST00000107922.2
Ccdc107

coiled-coil domain containing 107

chr15_-_80083374 0.093 ENSMUST00000081650.7
Rpl3
ribosomal protein L3
chr11_+_77462325 0.086 ENSMUST00000102493.1
Coro6
coronin 6
chr16_-_23127702 0.080 ENSMUST00000115338.1
ENSMUST00000115337.1
ENSMUST00000023598.8
Rfc4


replication factor C (activator 1) 4


chr6_-_124965485 0.080 ENSMUST00000112439.2
Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr5_-_16731074 0.079 ENSMUST00000073014.5
Gm8991
predicted pseudogene 8991
chr7_-_67372846 0.077 ENSMUST00000156690.1
ENSMUST00000107476.1
ENSMUST00000076325.5
ENSMUST00000032776.8
ENSMUST00000133074.1
Mef2a




myocyte enhancer factor 2A




chr10_-_69212996 0.076 ENSMUST00000170048.1
A930033H14Rik
RIKEN cDNA A930033H14 gene
chr17_-_58991343 0.074 ENSMUST00000025064.7
2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr7_-_144738478 0.073 ENSMUST00000121758.1
Ano1
anoctamin 1, calcium activated chloride channel
chr1_+_155558112 0.072 ENSMUST00000080138.6
ENSMUST00000097529.3
ENSMUST00000035560.3
Acbd6


acyl-Coenzyme A binding domain containing 6


chr13_-_23698454 0.071 ENSMUST00000102967.1
Hist1h4c
histone cluster 1, H4c
chr13_-_23368969 0.070 ENSMUST00000152557.1
Zfp322a
zinc finger protein 322A
chr4_-_131967824 0.067 ENSMUST00000146443.1
ENSMUST00000135579.1
Epb4.1

erythrocyte protein band 4.1

chr7_-_102100227 0.063 ENSMUST00000106937.1
Art5
ADP-ribosyltransferase 5
chr4_+_129287614 0.062 ENSMUST00000102599.3
Sync
syncoilin
chr12_+_86361112 0.062 ENSMUST00000116402.3
Esrrb
estrogen related receptor, beta
chr6_-_124965403 0.045 ENSMUST00000129446.1
ENSMUST00000032220.8
Cops7a

COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)

chr13_+_23934434 0.044 ENSMUST00000072391.1
Hist1h2aa
histone cluster 1, H2aa
chr10_-_39899238 0.044 ENSMUST00000178563.1
AA474331
expressed sequence AA474331
chr6_+_42286709 0.036 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr10_-_88605017 0.034 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr9_+_75051977 0.028 ENSMUST00000170310.1
ENSMUST00000166549.1
Arpp19

cAMP-regulated phosphoprotein 19

chr11_-_86671169 0.025 ENSMUST00000143991.1
Vmp1
vacuole membrane protein 1
chrX_-_8252304 0.025 ENSMUST00000115594.1
Ftsj1
FtsJ homolog 1 (E. coli)
chr18_-_80200597 0.024 ENSMUST00000025462.6
Rbfa
ribosome binding factor A
chr11_+_77801291 0.022 ENSMUST00000100794.3
Myo18a
myosin XVIIIA
chr1_+_9547948 0.016 ENSMUST00000144177.1
Adhfe1
alcohol dehydrogenase, iron containing, 1
chr15_+_94629148 0.014 ENSMUST00000080141.4
Tmem117
transmembrane protein 117
chr11_+_54303798 0.007 ENSMUST00000093106.5
Acsl6
acyl-CoA synthetase long-chain family member 6
chr17_+_29032664 0.005 ENSMUST00000130216.1
Srsf3
serine/arginine-rich splicing factor 3
chr18_+_60376029 0.003 ENSMUST00000066912.5
ENSMUST00000032473.6
Iigp1

interferon inducible GTPase 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.5 3.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 2.2 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.4 1.6 GO:0051866 general adaptation syndrome(GO:0051866)
0.4 1.5 GO:0042414 epinephrine metabolic process(GO:0042414)
0.4 1.1 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.3 1.7 GO:0015671 oxygen transport(GO:0015671)
0.3 0.9 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.3 1.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.3 0.9 GO:0070889 platelet alpha granule organization(GO:0070889)
0.3 0.8 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.3 0.8 GO:0060023 soft palate development(GO:0060023)
0.3 1.5 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 0.7 GO:0035523 protein K29-linked deubiquitination(GO:0035523) protein K6-linked deubiquitination(GO:0044313)
0.2 4.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 2.3 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.2 0.8 GO:0090669 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.2 1.0 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 0.6 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 1.0 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 1.8 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.1 1.5 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 1.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.9 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 0.5 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.6 GO:0001705 ectoderm formation(GO:0001705) ectodermal cell differentiation(GO:0010668)
0.1 0.3 GO:0015866 ADP transport(GO:0015866)
0.1 1.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.8 GO:0071494 cellular response to UV-C(GO:0071494)
0.1 0.7 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 0.3 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.1 0.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.1 0.3 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 0.8 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 0.4 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 1.5 GO:0001553 luteinization(GO:0001553)
0.1 0.4 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1 0.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.9 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.5 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.3 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1 3.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.4 GO:0015879 carnitine transport(GO:0015879)
0.0 0.2 GO:0046618 drug export(GO:0046618)
0.0 0.7 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 3.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.2 GO:0015705 iodide transport(GO:0015705)
0.0 0.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0050812 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0 0.3 GO:1902969 mitotic DNA replication(GO:1902969)
0.0 0.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.4 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.1 GO:0070375 ERK5 cascade(GO:0070375)
0.0 0.2 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.3 GO:0015809 arginine transport(GO:0015809)
0.0 0.4 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.8 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.6 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.5 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.0 1.4 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.1 GO:0090282 trophectodermal cell proliferation(GO:0001834) positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.0 0.8 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0048745 smooth muscle tissue development(GO:0048745)
0.0 0.4 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.6 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.5 GO:0061045 negative regulation of wound healing(GO:0061045)
0.0 0.2 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.5 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 1.7 GO:0007612 learning(GO:0007612)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.5 1.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 1.7 GO:0005833 hemoglobin complex(GO:0005833)
0.2 0.8 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.2 0.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.1 0.6 GO:0090537 CERF complex(GO:0090537)
0.1 0.4 GO:0045160 myosin I complex(GO:0045160)
0.1 1.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 0.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 3.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.8 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.4 GO:0043194 axon initial segment(GO:0043194)
0.0 0.4 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 2.0 GO:0031526 brush border membrane(GO:0031526)
0.0 0.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 4.5 GO:0001650 fibrillar center(GO:0001650)
0.0 2.5 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 3.1 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.2 GO:0031091 platelet alpha granule(GO:0031091)
0.0 0.2 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.2 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.1 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.4 1.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.4 1.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.3 1.0 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.3 1.3 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.3 1.5 GO:0035240 dopamine binding(GO:0035240)
0.3 1.0 GO:0004111 creatine kinase activity(GO:0004111)
0.2 1.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 0.6 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.2 2.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 0.7 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.4 GO:0005124 scavenger receptor binding(GO:0005124)
0.1 0.8 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 0.4 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 3.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.8 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 1.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 2.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.2 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.8 GO:0017046 peptide hormone binding(GO:0017046)
0.1 0.4 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 0.2 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 0.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.2 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.2 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.0 0.2 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 0.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 1.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 3.1 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.3 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.3 GO:0031432 titin binding(GO:0031432)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0004534 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160) 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 2.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 1.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.3 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.5 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.9 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 5.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 3.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.6 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.9 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 1.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.3 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 3.5 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 2.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 0.7 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.9 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.6 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME_LIPOPROTEIN_METABOLISM Genes involved in Lipoprotein metabolism
0.0 0.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME_TELOMERE_MAINTENANCE Genes involved in Telomere Maintenance
0.0 0.2 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.1 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex